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Nanocomplexes for in vivo control of cellular functions

Research Project

Project/Area Number 16H03834
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Nanomaterials engineering
Research InstitutionNational Institute of Advanced Industrial Science and Technology

Principal Investigator

Miyako Eijiro  国立研究開発法人産業技術総合研究所, 材料・化学領域, 主任研究員 (70443231)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2018: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2017: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2016: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Keywordsナノ材料 / ナノチューブ・フラーレン / ナノバイオ / 細胞・組織
Outline of Final Research Achievements

In the last decade, there has been great progress in technologies for the remote control of organisms through physical and chemical manipulation. In particular, methods involving lasers have proven useful for the control of biological functions in living organisms through simple manipulation with laser beams. Ultraviolet, short-wavelength visible, and infrared light are generally used in optical techniques for the control of biological functions in organisms. However, these types of light do not efficiently penetrate biological tissues. It is well known that near-infrared (NIR) rays can penetrate tissues because biological systems are relatively transparent to these wavelengths of light. We have developed NIR-laser-driven nanocomplexes for remote control of cellular functions. I believe that the technologies will help to create a new state-of-the-art tool for the comprehensive analysis of "real" biological molecular information at the single-cell level.

Academic Significance and Societal Importance of the Research Achievements

本研究は、従来のオプトジェネティクスやケージド化合物では不可能であった生体深部領域の生理活性制御が可能となるため、細胞機能のより詳細かつ厳密な分子メカニズムが解明できるようになる。このような分子メカニズムの解明は、とりわけガンのための分子標的医薬品の開発における重要な知見を与えることができる。このように本研究で提案する概念は、光による細胞機能制御研究に新境地を開き、先進医療分野において世界の科学・技術を大きくリードすることができるため学術的意義や社会的意義がある。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (20 results)

All 2019 2018 2017 2016 Other

All Int'l Joint Research (4 results) Journal Article (16 results) (of which Int'l Joint Research: 9 results,  Peer Reviewed: 16 results,  Acknowledgement Compliant: 4 results,  Open Access: 4 results)

  • [Int'l Joint Research] Nanyang Technological University(シンガポール)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Nanyang Technological University(シンガポール)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] CNRS/Strasbourg University(フランス)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Nanyang Technological University(シンガポール)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Spatially controlled molecular encapsulation in natural pine pollen microcapsules2019

    • Author(s)
      Arun Kumar Prabhakar, Michael G. Potroz, Soohyun Park, Eijiro Miyako, Nam-Joon Cho
    • Journal Title

      Particle & Particle Systems Characterization

      Volume: 35 Issue: 9 Pages: 1800151-1800151

    • DOI

      10.1002/ppsc.201800151

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Human blood plasma catalyses the degradation of Lycopodium plant sporoderm microcapsules2019

    • Author(s)
      Teng-Fei Fan, Michael G. Potroz, Ee-Lin Tan, Jae H. Park, Eijiro Miyako, Nam-Joon Cho
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 2944-2944

    • DOI

      10.1038/s41598-019-39858-z

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Microfluidic liquid cell chamber for scanning probe microscopy measurement application2019

    • Author(s)
      Hokyun Chin, Jurriaan J. J. Gillissen, Eijiro Miyako, Nam-Joon Cho
    • Journal Title

      Review of Scientific Instruments

      Volume: 90 Issue: 4 Pages: 046105-046105

    • DOI

      10.1063/1.5086063

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Self-assembled nanodiamond supraparticles for anticancer chemotherapy2018

    • Author(s)
      Yue Yu, Masahiro Nishikawa, Ming Liu, Takahiro Tei, Sunil C. Kaul, Renu Wadhawa, Minfang Zhang, Junko Takahashi, Eijiro Miyako
    • Journal Title

      Nanoscale

      Volume: N.A. Issue: 19 Pages: 8969-8978

    • DOI

      10.1039/c8nr00641e

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recent advances in liquid metal manipulation toward soft robotics and biotechnologies2018

    • Author(s)
      Yue Yu, Eijiro Miyako
    • Journal Title

      Chemistry - A European Journal

      Volume: N.A. Issue: 38 Pages: 9456-9462

    • DOI

      10.1002/chem.201800605

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alternating-magnetic-field-mediated wireless manipulations of a liquid metal for therapeutic bioengineering2018

    • Author(s)
      Yue Yu, Eijiro Miyako
    • Journal Title

      iScience

      Volume: N.A. Pages: 134-148

    • DOI

      10.1016/j.isci.2018.04.012

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Withaferin-A kills cancer cells with and without telomerase: Chemical, computational and experimental evidences2017

    • Author(s)
      Yue Yu, Shashank P. Katiyar, Durai Sundar, Zeenia Kaul, Eijiro Miyako, Zhen Zhang, Sunil C. Kaul, Roger R. Reddel, Renu Wadhwa
    • Journal Title

      Cell Death & Disease

      Volume: 8 Issue: 4 Pages: e2755-e2755

    • DOI

      10.1038/cddis.2017.33

    • NAID

      120007129074

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Materially engineered artificial pollinators2017

    • Author(s)
      Svetlana A. Chechetka, Yue Yu, Masayoshi Tange, Eijiro Miyako
    • Journal Title

      Chem

      Volume: 2 Issue: 2 Pages: 224-239

    • DOI

      10.1016/j.chempr.2017.01.008

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Light-driven liquid metal nanotransformers for biomedical theranostics2017

    • Author(s)
      Svetlana A. Chechetka, Yue Yu, Xu Zhen, Manojit Pramanik, Kanyi Pu, Eijiro Miyako
    • Journal Title

      Nature Communictions

      Volume: 8 Issue: 1 Pages: 15432-15432

    • DOI

      10.1038/ncomms15432

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Manipulation of biomolecule-modified liquid-metal blobs2017

    • Author(s)
      Yue Yu, Eijiro Miyako
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 56 Issue: 44 Pages: 13606-13611

    • DOI

      10.1002/anie.201705996

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Magnetically and Near-Infrared Light-Powered Supramolecular Nanotransporters for the Remote Control of Enzymatic Reactions2016

    • Author(s)
      S. A. Chechetka, E. Yuba, K. Kono, M. Yudasaka, A. Bianco, E. Miyako
    • Journal Title

      Angew. Chem. Int. Ed

      Volume: 55 Issue: 22 Pages: 6476-6481

    • DOI

      10.1002/anie.201602453

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Bioinspired polyaniline-functional natural hairs for pollen protection2016

    • Author(s)
      Svetlana A. Chechetka, Eijiro Miyako
    • Journal Title

      ChemistrySelect

      Volume: 5 Issue: 5 Pages: 1061-1065

    • DOI

      10.1002/slct.201600320

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Optical regulation of carbon nanodots by chemical functionalization2016

    • Author(s)
      Svetlana A. Chechetka, Eijiro Miyako
    • Journal Title

      ChemistrySelect

      Volume: N.A. Issue: 8 Pages: 854-856

    • DOI

      10.1246/cl.160429

    • NAID

      130005254490

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Carbon nanohorns allow acceleration of osteoblast differentiation via macrophages activation2016

    • Author(s)
      E. Hirata, E. Miyako, N. Hanagata, N. Ushijima, N. Sakaguchi, J. Russier, M. Yudasaka, S. Iijima, A. Bianco, A. Yokoyama
    • Journal Title

      Nanoscale,

      Volume: 8 Issue: 30 Pages: 14514-14522

    • DOI

      10.1039/c6nr02756c

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Semiconducting polymer nanobioconjugates for targeted photothermal activation of neurons2016

    • Author(s)
      Yan Lyu, Chen Xie, Svetlana A. Chechetka, Eijiro Miyako, Kanyi Pu
    • Journal Title

      Journal of the American Chemical Society

      Volume: 138 Issue: 29 Pages: 9049-9052

    • DOI

      10.1021/jacs.6b05192

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Photothermal and mechanical stimulation of cells via dualfunctional nanohybrids2016

    • Author(s)
      Svetlana A. Chechetka, Motomichi Doi, Benoit P. Pichon, Sylvie Begin-Colin, Eijiro Miyako
    • Journal Title

      Nanotechnology

      Volume: 27 Issue: 47 Pages: 475102-475112

    • DOI

      10.1088/0957-4484/27/47/475102

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research

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Published: 2016-04-21   Modified: 2020-03-30  

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