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Development of temperature-responsive lipid nano-devices for spatiotemporally controlled payload release

Research Project

Project/Area Number 16H03844
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Nano/Microsystems
Research InstitutionWaseda University

Principal Investigator

Sou Keitaro  早稲田大学, 理工学術院, 客員主任研究員 (20318835)

Co-Investigator(Kenkyū-buntansha) 新井 敏  早稲田大学, 理工学術院, 次席研究員(研究院講師) (70454056)
Research Collaborator SATO Hirotaka  
LEE Chi-Lik Ken  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2018: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Keywordsリポソーム / ナノ粒子 / 薬物送達 / 神経伝達物質 / 蛍光温度センサー / 温度応答性材料 / 脂質ベシクル / ナノバイオテクノロジー / 脂質カプセル / 相転移 / ドラッグデリバリーシステム / 蛍光色素 / 温度センサ / 温度応答性 / マイクロ・ナノデバイス / ナノ材料 / 脂質 / 蛍光イメージング / 蛍光プローブ / 近赤外線
Outline of Final Research Achievements

The aim of this study is to develop nano-devices that release a payload timely at a target region to apply them for delivery and controlled release of functional molecules such as drugs. To this end, temperature-responsive lipid nano-capsules that release the payloads when heated to a threshold temperature have been developed. These nano-capsules successfully released the drugs at target region by heating the tissue up to the threshold temperature in living organism. In addition, a technique for spatial temperature monitoring to precisely control the temperature at small space where the conventional thermometers can not be applied has been investigated.

Academic Significance and Societal Importance of the Research Achievements

体の中の細胞間情報伝達やがんの転移など様々な生命現象において、細胞が放出する超小型脂質カプセルによる分子送達の関与が明らかになってきた。本研究で開発した脂質ナノカプセルは、このような生命現象を人工的に再現するモデルとなり、学術的に意義のある研究対象である。また、この脂質ナノカプセルを薬物送達システム(DDS)に応用することで、次世代の安全な病気の治療法の開発への貢献が期待できる。微小領域の温度モニタリングの手法は、温度とナノサイエンスを融合する新しい境界領域の発展を支える研究ツールとして学術的に高い波及効果が期待できるとともに、治療における生体組織の精密な温度制御を可能にする。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (18 results)

All 2019 2018 2017 2016 Other

All Int'l Joint Research (3 results) Journal Article (7 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 7 results,  Open Access: 1 results,  Acknowledgement Compliant: 2 results) Presentation (3 results) (of which Int'l Joint Research: 2 results) Book (1 results) Remarks (4 results)

  • [Int'l Joint Research] Nanyang Technological University/Singapore Polytechnic(シンガポール)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Nanyan Technological University (NTU)/Singapore Polytechnic(シンガポール)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Singapore Polytechnic/Nanyan Technological University(シンガポール)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Nanocapsules for programmed neurotransmitter release: Toward artificial extracellular synaptic vesicles2019

    • Author(s)
      Keitaro Sou, Duc Long Le, Hirotaka Sato
    • Journal Title

      Small

      Volume: 15 Issue: 17 Pages: 1900132-1900132

    • DOI

      10.1002/smll.201900132

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Drug Delivery: Nanocapsules for Programmed Neurotransmitter Release: Toward Artificial Extracellular Synaptic Vesicles2019

    • Author(s)
      Keitaro Sou, Duc Long Le, Hirotaka Sato
    • Journal Title

      Small

      Volume: 15 Issue: 17 Pages: 1970088-1970088

    • DOI

      10.1002/smll.201970088

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 温度応答性リポソームの開発と薬物送達システムへの応用2018

    • Author(s)
      宗 慶太郎
    • Journal Title

      人工血液

      Volume: 26 Pages: 51-58

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neurotransmitter-loaded nanocapsule triggers on-demand muscle relaxation in living organism2018

    • Author(s)
      Duc Long Le, Ferdinandus, Chin Kiat Tnee, T. Thang Vo Doan, Satoshi Arai, Madoka Suzuki, Keitaro Sou, Hirotaka Sato
    • Journal Title

      ACS Applied Materials & Interfaces

      Volume: 10 Issue: 44 Pages: 37812-37819

    • DOI

      10.1021/acsami.8b11079

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Far-red fluorescent liposomes for folate receptor-targeted bioimaging2018

    • Author(s)
      Sheng Dong, Joshua Ding Wei Teo, Li Yan Chan, Chi-Lik Ken Lee, and Keitaro Sou
    • Journal Title

      ACS Appl. Nano Mater.

      Volume: 1 Issue: 3 Pages: 1009-1013

    • DOI

      10.1021/acsanm.8b00084

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Photo-switchable and self-erasable fluorescent nanoprobe2017

    • Author(s)
      Keitaro Sou, Li Yan Chan, Chi-Lik Ken Lee
    • Journal Title

      Journal of Photochemistry and Photobiology A: Chemistry

      Volume: 332 Pages: 25-31

    • DOI

      10.1016/j.jphotochem.2016.08.001

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Temperature tracking in a three-dimensional matrix using thermosensitive liposome platform2016

    • Author(s)
      Keitaro Sou, Li Yan Chan, Chi-Lik Ken Lee,
    • Journal Title

      ACS Sensors

      Volume: 1(6) Issue: 6 Pages: 650-655

    • DOI

      10.1021/acssensors.6b00222

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Concomitant monitoring of local heating and heat-triggered cargo release from thermosensitive liposomes by fluorescence imaging2017

    • Author(s)
      Keitaro Sou, Satoshi Arai, Li Yan Chan, Chi-Lik Ken Lee
    • Organizer
      5th International Symposium for Bioimaging
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 細胞内薬物動態制御に向けた温度応答性リポソームの開発2017

    • Author(s)
      宗 慶太郎, 新井敏, Li Yan Chan, Chi-Lik Ken Lee
    • Organizer
      第24回日本血液代替物学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Thermosensitive liposomes for controlled release with near-infrared light2016

    • Author(s)
      Keitaro Sou
    • Organizer
      3rd 3D Lab exchange symposium
    • Place of Presentation
      Pisa Italy
    • Year and Date
      2016-09-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Book] DDS先端技術の製剤への応用開発2017

    • Author(s)
      宗 慶太郎,田口和明
    • Total Pages
      9
    • Publisher
      技術情報協会
    • ISBN
      9784861046636
    • Related Report
      2017 Annual Research Report
  • [Remarks] SOU Research Group

    • URL

      https://sites.google.com/site/soulabwabios/

    • Related Report
      2018 Annual Research Report
  • [Remarks] SOU RESEARCH GROUP

    • URL

      https://sites.google.com/site/soulabwabios

    • Related Report
      2017 Annual Research Report
  • [Remarks] Waseda Bioscience Research Institute in Singapore

    • URL

      http://www.waseda.jp/WABIOS/jp/

    • Related Report
      2016 Annual Research Report
  • [Remarks] SOU RESEARCH GROUP

    • URL

      http://sites.google.com/site/soulabwabios/

    • Related Report
      2016 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

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