| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2018: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
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| Outline of Final Research Achievements |
We performed systematic study on dynamic planar chiral heterocycles: nine-membered E,Z-diallylic heterocycles and [7]-orthocyclphenes, and found that their stereochemical stabilities are highly dependent on substituent on the E-alkene, embedded heteroatom X in the ring, and ring size. Also we have found that stereochemical stability of the planar chiral molecules can be controlled by addition of Lewis acid. Furthermore, we have developed dynamic asymmetric induction method which provides enantioenriched forms of the planar chiral molecules.
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