| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2018: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2017: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2016: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Outline of Final Research Achievements |
Inorganic components consisting of multiple transition metals and sulfur atoms are designated as metal-sulfur clusters, which are essential for various biological functions. The largest biological metal-sulfur cluster thus far structurally identified is the nitrogenase FeMo-cofactor, which catalyzes the reduction of N2 into NH3 under physiological conditions. Although various metal-sulfur clusters structurally relevant to FeMo-cofactor have been synthesized over the years, their use in the activation of N2 has proven challenging to realize, and even the FeMo-cofactor extracted from the protein to organic solvents has not been found to reduce N2. In this research project, we synthesized a series of Cp* (C5Me5)-supported cubic [Mo3S4M] clusters, and demonstrated the activation of N2 and its conversion into NH3 and N2H4 on the [Mo3S4Ti] variant. This result represents an initial step toward modeling the reducing function of the FeMo-cofactor.
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