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Development of Stimuli-Responsive Nanoscale Molecular Systems Mimicking Biological Systems

Research Project

Project/Area Number 16H04129
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Functional solid state chemistry
Research InstitutionTokyo Institute of Technology

Principal Investigator

Kinbara Kazushi  東京工業大学, 生命理工学院, 教授 (30282578)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2018: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2016: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Keywords二分子膜 / イオンチャネル / 分子機械 / 相転移 / ヒステリシス / メカノセンシティブチャネル / 両親媒性分子 / 刺激応答性 / 熱応答 / オリゴエチレングリコール / マルチブロック分子 / マルチブロック / メカノセンシティブイオンチャネル / 張力 / マルチブロック構造 / 超分子化学 / ポリエチレングリコール / 生物模倣 / 自己組織化 / 分子デバイス
Outline of Final Research Achievements

Inspired by the structure of a protein contained in a cell membrane, functional amphiphilic molecules having a backbone with alternately connected hydrophilic and hydrophobic parts are designed, and their synthetic routes have been established. The designed molecules showed unique response to external thermal or physical stimuli to change its assembling structures, and resulted in the changes of their physical properties.

Academic Significance and Societal Importance of the Research Achievements

本研究の成果は,細胞内でタンパク質により行われている様々なセンシング,例えば温度センシングや力学センシングを,人工分子でも実現できることを示した先駆的な結果であり,ナノメートルサイズの微小センサーを構築する分子設計を可能とする,大きなブレークスルーをもたらすことが期待される。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (46 results)

All 2019 2018 2017 2016 Other

All Int'l Joint Research (5 results) Journal Article (6 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 6 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (35 results) (of which Int'l Joint Research: 11 results,  Invited: 10 results)

  • [Int'l Joint Research] CNRS/IECB/ボルドー大学(フランス)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] ボルドー大学(フランス)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] アイルランド国立大学(アイルランド)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] ボルドー大学(フランス)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] アイルランド国立大学(アイルランド)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Heat-Triggered Crystallization of Liquid Crystalline Macrocycles Allowing for Conductance Switching through Hysteretic Thermal Phase Transitions2018

    • Author(s)
      Muraoka Takahiro、Shima Tatsuya、Kajitani Takashi、Hoshino Norihisa、Morvan Estelle、Grelard Axelle、Dufourc Erick J.、Fukushima Takanori、Akutagawa Tomoyuki、Nabeya Kota、Kinbara Kazushi
    • Journal Title

      Chemistry - An Asian Journal

      Volume: 14 Issue: 1 Pages: 141-148

    • DOI

      10.1002/asia.201801372

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Localization of transmembrane multiblock amphiphilic molecules in phase-separated vesicles2018

    • Author(s)
      Kazushi Kinbara, Kaori Umetsu, Hiroki Sonobe, Takahiro Muraoka, Naofumi Shimokawa, Masahiro Takagi
    • Journal Title

      Faraday Discussions

      Volume: 印刷中 Pages: 315-328

    • DOI

      10.1039/c8fd00022k

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Newly characterized interaction stabilizes DNA structure: oligoethylene glycols stabilize G-quadruplexes CH?π interactions2017

    • Author(s)
      Tateishi-Karimata Hisae、Ohyama Tatsuya、Muraoka Takahiro、Podbevsek Peter、Wawro Adam M.、Tanaka Shigenori、Nakano Shu-ichi、Kinbara Kazushi、Plavec Janez、Sugimoto Naoki
    • Journal Title

      Nucleic Acids Research

      Volume: 45 Issue: 12 Pages: 7021-7030

    • DOI

      10.1093/nar/gkx299

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Thermally-Induced Lateral Assembly of PEG-Containing Amphiphile Triggering Vesicle Budding2017

    • Author(s)
      Rui Li, Takahiro Muraoka, and Kazushi Kinbara
    • Journal Title

      Chem. Commun.

      Volume: 53 Issue: 85 Pages: 11662-11665

    • DOI

      10.1039/c7cc06489f

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechano-Sensitive Synthetic Ion Channels2017

    • Author(s)
      Takahiro Muraoka, Kaori Umetsu, Kazuhito V. Tabata, Tsutomu Hamada, Hiroyuki Noji, Takashi Yamashita, and Kazushi Kinbara
    • Journal Title

      J. Am. Chem. Soc.

      Volume: 139 Issue: 49 Pages: 18016-18023

    • DOI

      10.1021/jacs.7b09515

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Multigram Chromatography-free Synthesis of Octa(ethylene glycol) p-Toluenesulfonate2016

    • Author(s)
      Adam M. Wawro, Takahiro Muraoka, Maho Kato, and Kazushi Kinbara
    • Journal Title

      Org. Chem. Front.

      Volume: 11 Issue: 11 Pages: 1524-1534

    • DOI

      10.1039/c6qo00398b

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Protein Cyborgization by Main Chain Substitution2019

    • Author(s)
      AOKI, Yusuke; UI, Mihoko; MATSUI, Takashi;TANAKA, Yoshikazu; MURAOKA, Takahiro; SATO, Kohei; KINBARA, Kazushi
    • Organizer
      日本化学会第99春季年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Development of Multiblock Amphiphilic Molecules bearing Dihy- droimidazolium Ion2019

    • Author(s)
      MORI, Miki; SATO, Kohei; KINBARA, Kazushi
    • Organizer
      日本化学会第99春季年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Development of multiblock arene-perfluoroarene macrocycle2019

    • Author(s)
      SATO, Kohei; NABEYA, Kota; MURAOKA, Takahiro; HOSHINO, Norihisa; AKUTAGAWA, Tomoyuki; KINBARA, Kazushi
    • Organizer
      日本化学会第99春季年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Synthesis and Properties of Multiblock Amphiphilic Ligand Molecules2018

    • Author(s)
      Miki Mori, Kohei Sato, Kazushi Kinbara
    • Organizer
      The 12th SPSJ International Polymer Conference (IPC2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Macrocyclic Multiblock Amphiphilic PEGs for Biorelated Applications2018

    • Author(s)
      Yudai Nakagawa, Kohei Sato, Adam M. Wawro, Kazushi Kinbara
    • Organizer
      The 12th SPSJ International Polymer Conference (IPC2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthetic mimics of transmembrane proteins2018

    • Author(s)
      Kazushi Kinbara
    • Organizer
      The 79th Okazaki Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Approach to molecular engines: Design of stimuli-responsive molecules mimicking dynamic functions of transmembrane proteins2018

    • Author(s)
      Kazushi Kinbara
    • Organizer
      Hokkaido-Strasbourg Symposium Biotic and Abiotic Molecular Machines and Motors
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Design of stimuli-responsive molecules mimicking dynamic functions of transmembrane proteins2018

    • Author(s)
      Kazushi Kinbara
    • Organizer
      Tokyo Tech NCCR Molecular Systems Engineering Joint Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 大環状マルチブロック両親媒性PEGの開発と機能開拓2018

    • Author(s)
      中川優大・佐藤浩平・Adam M. Wawro・金原 数
    • Organizer
      第8回CSJ化学フェスタ
    • Related Report
      2018 Annual Research Report
  • [Presentation] リン酸エステル含有交互両親媒性分子の合成と物性評価2018

    • Author(s)
      三栖花梨・佐藤浩平・金原 数
    • Organizer
      第8回CSJ化学フェスタ
    • Related Report
      2018 Annual Research Report
  • [Presentation] 交互両親媒性リガンド分子の合成と物性2018

    • Author(s)
      森 水紀・佐藤浩平・金原 数
    • Organizer
      第8回CSJ化学フェスタ
    • Related Report
      2018 Annual Research Report
  • [Presentation] リガンド型膜貫通分子の構築2018

    • Author(s)
      園部宏樹・村岡貴博・金原数
    • Organizer
      第12回バイオ関連化学シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 側方相分離の制御を目指した両親媒性ステロイド多量体の構築2018

    • Author(s)
      加藤真帆・村岡貴博・金原 数
    • Organizer
      日本化学会第98春季年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 熱応答性メカニカル結晶の設計に向けて2018

    • Author(s)
      金原 数
    • Organizer
      日本化学会第98春季年会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] オリゴシラン骨格からなるσ共役系環境応答性蛍光分子の開発2018

    • Author(s)
      片岡 拓也・村岡 貴博・金原 数
    • Organizer
      日本化学会第98春季年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Development of Stimuli Responsive Alternating Amphiphilic Molecule Bearing Bipyridine Units2018

    • Author(s)
      SONOBE, Hiroki; MURAOKA, Takahiro; KINBARA, Kazushi
    • Organizer
      日本化学会第98春季年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Development of Branched-PEG Molecule which Regulates Protein Higher-Order Structures2018

    • Author(s)
      KAWAME, Mayu; MURAOKA, Takahiro; KINBARA, Kazushi
    • Organizer
      日本化学会第98春季年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Novel Reagents for Protein Modification and Purification with Enzymatically Cleavable Tag2018

    • Author(s)
      AOKI, Yusuke; M. WAWRO, Adam; MURAOKA, Takahiro; KINBARA, Kazushi
    • Organizer
      日本化学会第98春季年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] タンパク質の凝集抑制効果を示す両親媒性分子の開発2017

    • Author(s)
      川目真悠・村岡貴博・金原 数
    • Organizer
      第7回CSJ化学フェスタ2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] ビピリジン含有交互両親媒性分子の開発2017

    • Author(s)
      園部宏樹・村岡貴博・金原 数
    • Organizer
      第7回CSJ化学フェスタ2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] タンパク質のPEG化および精製のための高効率タグの構築2017

    • Author(s)
      青木祐輔・AdamM.Wawro・村岡貴博・金原 数
    • Organizer
      第7回CSJ化学フェスタ2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] Monodisperse Engineered PEGs for Biorelated Applications2017

    • Author(s)
      Kazushi Kinbara
    • Organizer
      Advances in Noncanonical Nucleic Acids (ANNA2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of Stimuli-responsive Alternating Multiblock Amphiphiles as Mimics for Transmembrane Proteins2017

    • Author(s)
      Kazushi Kinbara
    • Organizer
      International seminar on biophysics and chemical biology of biomembrane and lipid bilayers
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 短鎖単分散オリゴエチレングリコールを利用した機能分子の開発2017

    • Author(s)
      金原 数
    • Organizer
      高分子コロキウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Properties and Bio-related applications of amphiphilic molecules comprising monodisperse short PEGs2017

    • Author(s)
      Kazushi Kinbara
    • Organizer
      ISPAC2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] マルチブロック型大環状化合物の熱結晶多形転移現象2017

    • Author(s)
      鍋谷光太・村岡貴博・星野哲久・芥川智行・梶谷孝・ 福島孝典・金原数
    • Organizer
      日本化学会第97春季年会
    • Related Report
      2016 Annual Research Report
  • [Presentation] Spectroscopic property of oligosilane derivatives in lipid aggregates2017

    • Author(s)
      KATAOKA, Takuya; MURAOKA, Takahiro; KINBARA, Kazushi
    • Organizer
      日本化学会第97春季年会
    • Related Report
      2016 Annual Research Report
  • [Presentation] Construction of photoresponsive protein-polymer conjugates based on a junctional photoreceptor2017

    • Author(s)
      UI, Mihoko; MIYAUCHI, Yusuke; MURAKAMI, Makoto; ARAKI, Yasuyuki; WADA, Takehiko; KINBARA, Kazushi
    • Organizer
      日本化学会第97春季年会
    • Related Report
      2016 Annual Research Report
  • [Presentation] Synthesis and Functions of Multi-block Oligomers with Steroids2016

    • Author(s)
      Maho Kato, Takahiro Muraoka and Kazushi Kinbara
    • Organizer
      The 11th SPSJ International Polymer Conference
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ポリシラン骨格含有分子の開発と脂質集合体中での分光学的特性2016

    • Author(s)
      片岡拓也・村岡貴博・金原 数
    • Organizer
      第6回CSJ化学フェスタ
    • Related Report
      2016 Annual Research Report
  • [Presentation] ステロイド含有交互両親媒性分子の開発2016

    • Author(s)
      加藤真帆・村岡貴博・金原 数
    • Organizer
      第6回CSJ化学フェスタ
    • Related Report
      2016 Annual Research Report
  • [Presentation] 大環状交互両親媒性化合物の開発と熱物性解析2016

    • Author(s)
      鍋谷光太・村岡貴博・金原 数
    • Organizer
      第6回CSJ化学フェスタ
    • Related Report
      2016 Annual Research Report
  • [Presentation] マルチブロック大環状化合物の結晶多形転移2016

    • Author(s)
      鍋谷光太・村岡貴博・金原 数
    • Organizer
      第26回日本MRS年次大会
    • Related Report
      2016 Annual Research Report
  • [Presentation] Design of Stimuli-Responsive Molecular Materials based on PEG-based Macrocycles2016

    • Author(s)
      Kazushi Kinbara
    • Organizer
      Energy and Movement in Coherent Chemical Systems
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Construction of Stimuli-Responsive Vesicles Including Asymmetric Functional Amphiphiles2016

    • Author(s)
      Kazushi Kinbara
    • Organizer
      Symmetry Festival 2016
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited

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Published: 2016-04-21   Modified: 2021-03-11  

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