| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2016: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Outline of Final Research Achievements |
Previous photosensitizers using a photodynamic therapy must have both high visible light absorption and generation ability of singlet oxygen by energy transfer because the photosensitizer consists of one molecule. Therefore, we separated these functions using a photo-antenna molecule and an active molecule. We succeeded to prepare dyad systems consisting of a C60 derivative with a polar group and an anthocyanin dye with an absorption maximum at 648 nm in a lipid membrane. The dyad system has a high photodynamic activity. Furthermore, the dyad systems have high photodynamic activity in the full range of visible light wavelength by the selection of a photo-antenna molecule. Therefore, we prepared antibiotic agents which act in the wide range of light wavelength.
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