| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2018: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
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| Outline of Final Research Achievements |
We succeeded in the synthesis of new α- and β-cyclodextrin (CD) dimers in which two α- and β-CD molecules are connected with six and seven m-xylylene linkers, respectively, by the reaction of 6-O-tert-butyldimethylsilylated α- and β-CD (TBDMS-α- and β-CD) with m-xylylene dibromide. We also synthesized Janus CD dimers by the selective elimination of TBDMS groups on one CD ring from the TBDMS-α- and β-CD dimers. We found that the α-CD dimer showed selective inclusion ability toward trans-fatty acid esters.
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