Identification of Muscle Synergy during Sit-to-stand Motion of Post Stroke Patients and Development of Rehabilitation Methodology

• Project/Area Number: 16H04293
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Intelligent mechanics/Mechanical systems
• Research Institution: The University of Tokyo
• Principal Investigator: Asama Hajime 東京大学, 大学院工学系研究科(工学部), 教授 (50184156)
• Co-Investigator(Kenkyū-buntansha): 山下 淳 東京大学, 大学院工学系研究科(工学部), 准教授 (30334957) ; 安 ち 東京大学, 大学院工学系研究科(工学部), 助教 (70747873)
• Research Collaborator: Ishikawa Yuki ; Yang Ningjia ; Kogami Hiroki ; Yoshida Kazunori
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000); Fiscal Year 2018: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2016: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
• Keywords: リハビリテーション / 片麻痺患者 / 起立動作 / 筋シナジー / 福祉工学 / 立ち上がり動作 / 視覚 / 前庭感覚 / 片麻痺

Outline of Final Research Achievements

Rehabilitation for motor impaired post stroke patient is important issue. This study focused on human standing-up motion and extracted muscle synergies from post stroke patients. As a result, it is shown that the patients could not appropriately control activation of muscle synergy responsible for hip rising; activation peak timing was delayed or activation duration became longer. On the other hand, we investigated muscle synergy of healthy participants whose sensory input is disturbed. When visual input is disturbed, amplitude of the muscle synergy corresponding to posture stabilization became larger. When vestibular input is disturbed, duration time of muscle synergies corresponding to whole body extension and body stabilization became longer. These results imply that in rehabilitation program, it is important to reinforce sensory input of the stroke patient and improve activation timing of muslce synergies.

Academic Significance and Societal Importance of the Research Achievements

超高齢社会において脳卒中になり，運動障害が残る片麻痺患者の人数が増えている．これに対して効果的なリハビリテーションを行うためには，感覚情報を補助し，筋の活動タイミングを教示することが重要である．本研究では日常動作における起点となる起立動作を対象に，片麻痺患者における筋肉の活動の特徴を明らかにし，また健常者において感覚情報が筋活動にどのような影響を与えるかを調べた．今後これらの結果を用いることで感覚情報の強化に着目したリハビリテーション手法への応用が期待される．

Research Products

• [Journal Article] Skill Abstraction of Physical Therapists in Hemiplegia Patient Rehabilitation Using a Walking Assist Robot (2019)
  • Author(s): An Qi、Ishikawa Yuki、Wen Wen、Ishiguro Shu、Ohata Koji、Yamakawa Hiroshi、Tamura Yusuke、Yamashita Atsushi、Asama Hajime
  • Journal Title: International Journal of Automation Technology Volume: 13 Issue: 2 Pages: 271-278
  • DOI: 10.20965/ijat.2019.p0271
  • NAID: 130007607636
  • ISSN: 1881-7629, 1883-8022
  • Year and Date: 2019-03-05
  • Peer Reviewed / Open Access
• [Journal Article] Visual and Vestibular Inputs Affect Muscle Synergies Responsible for Body Extension and Stabilization in Sit-to-Stand Motion (2019)
  • Author(s): Yoshida Kazunori、An Qi、Yozu Arito、Chiba Ryosuke、Takakusaki Kaoru、Yamakawa Hiroshi、Tamura Yusuke、Yamashita Atsushi、Asama Hajime
  • Journal Title: Frontiers in Neuroscience Volume: 12 Pages: 1042-1042
  • DOI: 10.3389/fnins.2018.01042
  • Peer Reviewed / Open Access
• [Journal Article] Skill Extraction from Nursing Care Service Using Sliding Sheet (2018)
  • Author(s): An Qi、Nakagawa Junki、Yasuda Junko、Wen Wen、Yamakawa Hiroshi、Yamashita Atsushi、Asama Hajime、The University of Tokyo 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan、Recruit Co., Ltd., Tokyo, Japan、No Lifting Association in Japan, Kobe, Japan
  • Journal Title: International Journal of Automation Technology Volume: 12 Issue: 4 Pages: 533-541
  • DOI: 10.20965/ijat.2018.p0533
  • NAID: 130007402857
  • ISSN: 1881-7629, 1883-8022
  • Year and Date: 2018-07-05
  • Peer Reviewed / Open Access
• [Journal Article] Effect of Physical Therapy on Muscle Synergy Structure During Standing-Up Motion of Hemiplegic Patients (2018)
  • Author(s): Kogami Hiroki、An Qi、Yang Ningjia、Yamakawa Hiroshi、Tamura Yusuke、Yamashita Atsushi、Asama Hajime、Shimoda Shingo、Yamasaki Hiroshi、Itkonen Matti、Shibata-Alnajjar Fady、Hattori Noriaki、Kinomoto Makoto、Takahashi Kouji、Fujii Takanori、Otomune Hironori、Miyai Ichiro
  • Journal Title: IEEE Robotics and Automation Letters Volume: 3 Issue: 3 Pages: 2229-2236
  • DOI: 10.1109/lra.2018.2811050
  • Peer Reviewed
• [Journal Article] Evaluation of the Effect of Prime Stimulus on Sense of Agency in Stop Operation of the Object in Circular Motion (2017)
  • Author(s): Shunsuke Hamasaki, Qi An, Masataka Murabayashi, Yusuke Tamura, Hiroshi Yamakawa, Atushi Yamashita, and Hajime Asama
  • Journal Title: Journal of Advanced Computational Intelligence and Intelligent Informatics Volume: 21 Issue: 7 Pages: 1161-1171
  • DOI: 10.20965/jaciii.2017.p1161
  • NAID: 130007520161
  • ISSN: 1343-0130, 1883-8014
  • Year and Date: 2017-11-20
  • Peer Reviewed
• [Journal Article] Continuous estimation of stress using physiological signals during a car race. (2017)
  • Author(s): Wen W, Tomoi D, Yamakawa H, Yamakawa H, Hamasaki S, Takakusaki K, An Q, Tamura Y, Yamashita A, Asama H
  • Journal Title: Psychology Volume: 8 Issue: 07 Pages: 978-986
  • DOI: 10.4236/psych.2017.87064
  • Peer Reviewed / Open Access
• [Journal Article] Skill training system for rowing motion using integrated presentation of motion and muscle activation (2016)
  • Author(s): Qi An, 柳井香史朗，中川純希，温文，山川博司，山下淳，淺間一
  • Journal Title: Transactions of the JSME (in Japanese) Volume: 82 Issue: 834 Pages: 15-00424-15-00424
  • DOI: 10.1299/transjsme.15-00424
  • NAID: 130005129137
  • ISSN: 2187-9761
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Goal-directed movement enhances body representation updating (2016)
  • Author(s): W. Wen, K. Muramatsu, S. Hamasaki, Q. An, H. Yamakawa, Y. Tamura, A. Yamashita, and H. Asama
  • Journal Title: Frontiers in Human Neuroscience Volume: 10 Pages: 1-10
  • DOI: 10.3389/fnhum.2016.00329
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Rehabilitation Intervention of Physical Therapists Improves Muscle Synergy during Standing-up Motion of Stroke Patients (2018)
  • Author(s): Qi An
  • Organizer: 2nd International Symposium on Embodied-Brain Systems Science (EmboSS2018)
  • Int'l Joint Research
• [Presentation] Clarification of Altered Muscle Synergies during Sit-to-stand Motion in Stroke Patients (2018)
  • Author(s): Ningjia Yang
  • Organizer: 2nd International Symposium on Embodied-Brain Systems Science (EmboSS2018)
  • Int'l Joint Research
• [Presentation] Effect of Physical Therapy on Joint Angle of Hemiplegic Patients during Standing-up Motion (2018)
  • Author(s): Hiroki Kogami
  • Organizer: 2nd International Symposium on Embodied-Brain Systems Science (EmboSS2018)
  • Int'l Joint Research
• [Presentation] Effect of Physical Therapy on Muscle Synergy Structure during Standing-up Motion of Hemiplegic Patients (2018)
  • Author(s): Hiroki Kogami
  • Organizer: 2018 IEEE International Conference on Robotics and Automation (ICRA2018)
  • Int'l Joint Research
• [Presentation] 片麻痺患者の起立動作のリハビリテーションにおける理学療法士の技能と筋シナジーに与える影響の調査 (2018)
  • Author(s): Qi An
  • Organizer: 計測自動制御学会システム・情報部門学術講演会2018
• [Presentation] 片麻痺患者の起立動作のリハビリテーションにおける理学療法士の技能と筋シナジーに与える影響の調査 (2018)
  • Author(s): 湖上碩樹
  • Organizer: 計測自動制御学会システム・情報部門学術講演会2018
• [Presentation] Clarification of Muscle Synergy Structure During Standing-Up Motion of Healthy Young, Elderly and Post-Stroke Patients (2017)
  • Author(s): Ningjia Yang, Qi An, Hiroshi Yamakawa, Yusuke Tamura, Atsushi Yamashita, Matti Itkonen, Fady Alnajjar, Shingo Shimoda, Hajime Asama, Noriaki Hattori and Ichiro Miyai
  • Organizer: 2017 International Conference on Rehabilitation Robotics (ICORR)
  • Int'l Joint Research
• [Presentation] Clarication of Muscle Synergy Structure During Standing-up Motion of Healthy Young, Elderly and Post-Stroke Patients (2017)
  • Author(s): Ningjia Yang, Qi An, Hiroki Kogami, Hiroshi Yamakawa, Yusuke Tamura, Atsushi Yamashita, Hajime Asama, Shingo Shimoda, Hiroshi Yamasaki, Matti Itkonen, Fady Shibata-Alnajjar, Noriaki Hattori, Makoto Kinomoto, Kouji Takahashi, Takanori Fujii, Hironori Otomune and Ichiro Miyai
  • Organizer: 計測自動制御学会システム・情報部門学術講演会2017（SSI2017）
• [Presentation] 片麻痺患者の起立動作のリハビリテーションにおける理学療法士の技能の解析 (2017)
  • Author(s): 湖上碩樹, Qi An, 楊濘嘉, 山川博司, 田村雄介, 山下淳, 淺間一, 山崎弘嗣, Matti Itkonen, Fady Shibata-Alnajjar, 下田真吾, 服部憲明, 木野本誠, 高橋幸治, 藤井崇典, 乙宗宏範, 宮井一郎
  • Organizer: 計測自動制御学会システム・情報部門学術講演会2017
• [Presentation] カロリックテストを用いた前庭感覚が起立動作の筋シナジーに与える影響の解明 (2017)
  • Author(s): 吉田和憲, Qi An, 四津有人, 千葉龍介, 高草木薫, 山川博司, 田村雄介, 山下淳, 淺間一
  • Organizer: 第22回ロボティクスシンポジア
• [Presentation] 若年者と高齢者の起立から歩行へ遷移する動作における運動学的解析 (2017)
  • Author(s): Qi An, 山川博司, 山下淳, 淺間一
  • Organizer: 第29回自律分散システム・シンポジウム
• [Presentation] 前庭感覚と視覚が起立動作の筋シナジーに与える影響の解析 (2017)
  • Author(s): 吉田和憲, 安琪, 四津有人, 千葉龍介, 高草木薫, 山川博司, 田村雄介, 山下淳, 淺間一
  • Organizer: 第26回ライフサポート学会フロンティア講演会
• [Presentation] Muscle Synergy Analysis in Human Standing-up Motion Using Different Strategies (2016)
  • Author(s): Ningjia Yang, Qi An, Hiroshi Yamakawa, Yusuke Tamura, Atsushi Yamashita and Hajime Asama
  • Organizer: 1st International Symposium on Embodied-Brain Systems Science (EmboSS2016)
  • Int'l Joint Research
• [Presentation] Influence of Sense of Agency and Sense of Ownership on Body Representation Change of Human Upper Limb (2016)
  • Author(s): Shunsuke Hamasaki, Qi An, Wen Wen, Yusuke Tamura, Hiroshi Yamakawa, Atsushi Yamashita, Hajime Asama, Satoshi Unenaka, Satoshi Shibuya and Yukari Ohki
  • Organizer: 1st International Symposium on Embodied-Brain Systems Science (EmboSS2016)
  • Int'l Joint Research
• [Presentation] Temporal Structure of Muscle Synergy of Human Stepping Leg During Sit-to-Walk Motion (2016)
  • Author(s): Qi An, Hiroshi Yamakawa, Atsushi Yamashita and Hajime Asama
  • Organizer: 14th International Conference on Autonomous Intelligent Systems (IAS-14)
  • Int'l Joint Research
• [Presentation] Auxiliary System to Identify Patterns of Patients with Hemiplegia for Transferring Skill of Rehabilitation with Walking Assist Robot (2016)
  • Author(s): Yuki Ishikawa, Qi An, Wen Wen, Shu Ishiguro, Koji Ohata, Hiroshi Yamakawa, Yusuke Tamura, Atsushi Yamashita and Hajime Asama
  • Organizer: Proceedings of the 4th International Conference on Serviceology (ICServ2016)
  • Int'l Joint Research
• [Presentation] Different Temporal Structure of Muscle Synergy Between Sit-to-Walk and Sit-to-Stand Motions in Human Standing Leg (2016)
  • Author(s): Qi An, Hiroshi Yamakawa, Atsushi Yamashita and Hajime Asama
  • Organizer: 3rd International Conference on Neurorehabilitation (ICNR2016)
  • Int'l Joint Research
• [Presentation] How Anticipation for the Sense of Agency Affects Readiness Potential (2016)
  • Author(s): Rin Minohara, Wen Wen, Shunsuke Hamasaki, Takaki Maeda, Qi An, Yusuke Tamura, Hiroshi Yamakawa, Atsushi Yamashita and Hajime Asama
  • Organizer: 2016 International Symposium on Micro-Nano Mechatronics and Human Science (MHS2016)
  • Int'l Joint Research
• [Presentation] 起立動作において視覚情報の有無が 下肢の筋シナジーに与える影響の解析 (2016)
  • Author(s): 吉田和憲, Qi An, 石川雄己, 山川博司, 田村雄介, 山下淳, 淺間一
  • Organizer: 第34回日本ロボット学会学術講演会
• [Presentation] ヒトの起立から歩行への遷移動作における筋シナジーの適応的な構造の変化 (2016)
  • Author(s): Qi An，山川博司, 山下淳, 淺間一
  • Organizer: 第31回生体・生理工学シンポジウム ライフエンジニアリング部門シンポジウム2016