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Clarification of self-adjusting capacity of strength in bone focusing on osteocytes

Research Project

Project/Area Number 16H04517
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Structural/Functional materials
Research InstitutionOsaka University

Principal Investigator

Ishimoto Takuya  大阪大学, 工学研究科, 准教授 (50508835)

Co-Investigator(Kenkyū-buntansha) 中野 貴由  大阪大学, 工学研究科, 教授 (30243182)
松垣 あいら  大阪大学, 工学研究科, 助教 (10592529)
Research Collaborator Sekita Aiko  
Kadota Kohei  
Inagaki Yuhei  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2018: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2016: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Keywords機能適応 / 骨 / 配向性 / 力学機能 / ひずみ / オステオサイト細胞 / 異方的ひずみ場 / 強制負荷 / 骨強度 / 骨材質異方性 / オステオサイト / 細胞形態 / 細胞配列 / アパタイト配向性 / 骨力学機能 / 異方性 / 骨細管 / 応力・ひずみ / 異方性-等方性 / メカニズム解明
Outline of Final Research Achievements

Bone expresses an anisotropic mechanical function in the direction of mechanical stimuli due to the formation of preferential orientation of collagen and apatite. However, the relationship among mechanical stimuli, collagen/apatite orientation, and osteocytes as a mechanosensor remains un-elucidated. In this study, the quantitative relationship among in vivo strain - osteocyte morphology - apatite orientation was shown, suggesting that strain sensitivity by osteocyte contributes to the formation of apatite orientation and mechanical strengthening in the direction of applied strain.

Academic Significance and Societal Importance of the Research Achievements

本研究成果は、骨がもつ、外部の力学的環境に合わせて自らの構造を改変し、強度を最適化する、「自己調整能力」の本質について、従来の負荷の大きさと骨密度の観点ではなく、負荷の方向性とそれに対応した骨微細構造の方向性(配向性)の観点から明らかとしたものである。さらに、骨内のセンサー細胞によるひずみの感受についても、その方向性を考慮することの重要性を示し、骨の自己調整能力のこれまでの理解を大幅に広げる知見となったと自負する。発展的には、例えば、骨の量のターゲットとして行われている骨治療やその薬剤の開発に関して、骨の配向性の観点を加えていく必要性を示唆するものである。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (18 results)

All 2019 2018 2017 2016

All Journal Article (7 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 7 results,  Open Access: 6 results,  Acknowledgement Compliant: 2 results) Presentation (11 results) (of which Int'l Joint Research: 2 results,  Invited: 5 results)

  • [Journal Article] Osteoporosis changes collagen/apatite orientation and Young’s modulus in vertebral cortical bone of rat2019

    • Author(s)
      Ryosuke Ozasa, Takuya Ishimoto, Sayaka Miyabe, Jun Hashimoto, Makoto Hirao, Hideki Yoshikawa, Takayoshi Nakano
    • Journal Title

      Calcified Tissue International

      Volume: 104 Issue: 4 Pages: 449-460

    • DOI

      10.1007/s00223-018-0508-z

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Trabecular health of vertebrae based on anisotropy in trabecular architecture and collagen/apatite micro-arrangement after implantation of intervertebral fusion cages in the sheep spine2018

    • Author(s)
      Ishimoto Takuya、Yamada Katsuhisa、Takahashi Hiroyuki、Takahata Masahiko、Ito Manabu、Hanawa Takao、Nakano Takayoshi
    • Journal Title

      Bone

      Volume: 108 Pages: 25-33

    • DOI

      10.1016/j.bone.2017.12.012

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Co-deteriorations of anisotropic extracellular matrix arrangement and intrinsic mechanical property in c-src deficient osteopetrotic mouse femur2017

    • Author(s)
      T. Ishimoto, B. Sato, J. -W. Lee, T. Nakano
    • Journal Title

      Bone

      Volume: 103 Pages: 216-223

    • DOI

      10.1016/j.bone.2017.06.023

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Unloading-induced degradation of the anisotropic arrangement of collagen/apatite in rat femurs2017

    • Author(s)
      Jun Wang, Takuya Ishimoto and Takayoshi Nakano
    • Journal Title

      Calcified Tissue International

      Volume: 100 Issue: 1 Pages: 87-94

    • DOI

      10.1007/s00223-016-0200-0

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Optimally Oriented Grooves on Dental Implants Improves Bone Quality around Implants under Repetitive Mechanical Loading2017

    • Author(s)
      Shinichiro Kuroshima, Takayoshi Nakano, Takuya Ishimoto, Muneteru Sasaki,Maaya Inoue, Munenori Yasutake, Takashi Sawase
    • Journal Title

      Acta Biomaterialia

      Volume: 48 Pages: 433-444

    • DOI

      10.1016/j.actbio.2016.11.021

    • NAID

      120006987588

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Synchronous disruption of anisotropic arrangement of the osteocyte network and collagen/apatite in melanoma bone metastasis2016

    • Author(s)
      Aiko Sekita; Aira Matsugaki, Takuya Ishimoto, Takayoshi Nakano
    • Journal Title

      Journal of Structural Biology

      Volume: 197 Issue: 3 Pages: 260-270

    • DOI

      10.1016/j.jsb.2016.12.003

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] アパタイト配向性と骨のメカノバイオロジー2016

    • Author(s)
      石本卓也, 中野貴由
    • Journal Title

      バイオマテリアル‐生体材料‐

      Volume: 34 Pages: 138-143

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Presentation] 骨再生・疾患における骨質因子としての骨基質配向性2018

    • Author(s)
      中野貴由、石本卓也、松垣あいら
    • Organizer
      日本補綴歯科学会第127回学術大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] メカニカルストレスに適応した 骨アパタイト配向化とヤング率の上昇2018

    • Author(s)
      石本卓也、中野貴由
    • Organizer
      第36回日本骨代謝学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] メカニカルストレスに適応した骨アパタイト配向化とヤング率の上昇2018

    • Author(s)
      石本卓也, 中野貴由
    • Organizer
      第36回日本骨代謝学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 卵巣摘出ならびに応力負荷の複合環境下における骨配向化2017

    • Author(s)
      石本卓也, 秀平忠司, 松垣あいら, 中野貴由
    • Organizer
      日本金属学会2017年春期(第160回)大会
    • Place of Presentation
      首都大学東京
    • Year and Date
      2017-03-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] 骨の機能適応変化に対する強制負荷ひずみ速度の影響2017

    • Author(s)
      門田耕平, 石本卓也, 中野貴由
    • Organizer
      日本金属学会2017年春期(第160回)大会
    • Place of Presentation
      首都大学東京
    • Year and Date
      2017-03-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] 骨細胞と骨基質アパタイト配向性2017

    • Author(s)
      中野貴由, 石本卓也, 松垣あいら
    • Organizer
      第59回歯科基礎医学会学術大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 強制的負荷に基づく骨配向化過程の解析2016

    • Author(s)
      門田耕平, 石本卓也, 中野貴由
    • Organizer
      日本金属学会2016年秋期(第159回)大会
    • Place of Presentation
      大阪大学豊中キャンパス
    • Year and Date
      2016-09-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] Change in preferential alignment of bone apatite in response to artificially altered principal strain in regenerated rat ulna2016

    • Author(s)
      T. Ishimoto, A. Murakami, T. Nakano
    • Organizer
      9th Pacific Rim International Conference on Advanced Materials and Processing (PRICM9)
    • Place of Presentation
      Kyoto International Conference Center
    • Year and Date
      2016-08-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 応力応答性に骨質を支配するアパタイト結晶配向性2016

    • Author(s)
      石本卓也, 中野貴由
    • Organizer
      日本補綴歯科学会第125回学術大会
    • Place of Presentation
      石川県立音楽堂
    • Year and Date
      2016-07-08
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 骨への強制的荷重負荷が骨形態・配向化に与える影響2016

    • Author(s)
      石本卓也, 門田耕平, 中野貴由
    • Organizer
      第36回日本骨形態計測学会
    • Place of Presentation
      朱鷺メッセ
    • Year and Date
      2016-06-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] Apatite orientation and material property of bone are enhanced by artificially elevated load2016

    • Author(s)
      T. Ishimoto, J. Wang, K. Kadota, T.W. Kim, T. Nakano
    • Organizer
      International Conference on Processing & Manufacturing of Advanced Materials (THERMEC’2011)
    • Place of Presentation
      Graz Convention Center
    • Year and Date
      2016-05-29
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited

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Published: 2016-04-21   Modified: 2020-03-30  

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