Development of growth factor-free tissue adhesives with angiogenic and tissue adhesive properties
| Project/Area Number |
16H04524
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Structural/Functional materials
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| Research Institution | National Institute for Materials Science |
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Principal Investigator |
Taguchi Tetsushi 国立研究開発法人物質・材料研究機構, 機能性材料研究拠点, グループリーダー (70354264)
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| Research Collaborator |
Nishiguchi Akihiro
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2018: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
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| Keywords | 接着剤 / 血管新生ゲル / 生体材料 |
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| Outline of Final Research Achievements |
An adhesive composed of hydrophobically-modified Alaska pollock-derived gelatin (hm-ApGltn) and a poly(ethylene glycol)-based crosslinker was obtained by introducing a hydrophobic group into original ApGltn (Org-ApGltn) having room temperature fluidity in order to create an adhesive having both angiogenic and tissue adhesive property. From the pressure test on porcine aorta, the prepared adhesive increased its pressure (adhesion) strength significantly by the introduction of hydrophobic groups. In addition, hm-ApGltn induced significantly higher production of vascular endothelial cell growth factor in macrophage-like cells as compared with Org-ApGltn. Furthermore, hm-ApGltn gel promoted angiogenesis significantly in the early stage of mouse subcutaneous implantation.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究で得られた材料は、生体内の湿潤環境において接着すると同時に、成長因子を追加することなく血管新生を誘導できることから、虚血性部位への適用や血管床を必要とする再生医療分野への展開が期待される。
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Report
(4 results)
Research Products
(50 results)
