| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2018: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
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| Outline of Final Research Achievements |
An adhesive composed of hydrophobically-modified Alaska pollock-derived gelatin (hm-ApGltn) and a poly(ethylene glycol)-based crosslinker was obtained by introducing a hydrophobic group into original ApGltn (Org-ApGltn) having room temperature fluidity in order to create an adhesive having both angiogenic and tissue adhesive property. From the pressure test on porcine aorta, the prepared adhesive increased its pressure (adhesion) strength significantly by the introduction of hydrophobic groups. In addition, hm-ApGltn induced significantly higher production of vascular endothelial cell growth factor in macrophage-like cells as compared with Org-ApGltn. Furthermore, hm-ApGltn gel promoted angiogenesis significantly in the early stage of mouse subcutaneous implantation.
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