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Neural mechanisms of detection of biological and temporal salience in primates

Research Project

Project/Area Number 16H04652
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurophysiology / General neuroscience
Research InstitutionUniversity of Toyama

Principal Investigator

NISHIJO HISAO  富山大学, 大学院医学薬学研究部(医学), 教授 (00189284)

Research Collaborator NISHIMARU HIROSHI  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2018: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Keywords霊長類 / 上丘 / 内側前頭葉 / 生物学的サリエンス / ヘビ / 顔 / 報酬予測 / 時間的サリエンス / 前内側前頭葉 / 内側前頭皮質 / サリエンス / 内側前頭前野 / 報酬 / 本能 / 注意 / 前頭極
Outline of Final Research Achievements

To investigate salience detection mechanisms in primates, we analyzed neuronal responses to visual stimuli in the extrageniculate system (superior colliculus, and pulvinar) as well as the medial frontal cortex that receives anatomical projections from the extrageniculate system in monkeys. The results indicated: 1) the medial frontal cortical neurons receive fast and coarse inputs from the extrageniculate system, and are involved in the detection of stimuli with biological salience (snakes and conspecific faces), and 2) collicular neurons in the deep layers showed climbing activities during the delay intervals before appearance of rewarding stimuli, and are involved in the temporal salience detection mechanisms predicting the emergence of rewarding stimuli.

Academic Significance and Societal Importance of the Research Achievements

我々は様々な感覚刺激を受けるが、これまでと異なる特別な刺激(サリエンスを有する刺激)に注意が喚起される。本研究では、サルを用いてニューロン活動を記録して視覚刺激に対する応答性を解析した結果、1)内側前頭前野は、生物学的サリエンスを有する刺激(天敵であるヘビや同種の顔)の検出に、および2)上丘の深層は、報酬刺激の出現を予測する時間的サリエンスを有する刺激の検出に関与することが明らかになった。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (26 results)

All 2019 2018 2017 2016 Other

All Int'l Joint Research (8 results) Journal Article (6 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 6 results,  Open Access: 4 results,  Acknowledgement Compliant: 3 results) Presentation (12 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results)

  • [Int'l Joint Research] ブラジリア大学(ブラジル)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] ブラジリア大学生物学研究所(ブラジル)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] カルフォルニア大学デービス校(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] 軍医大学医学部(ベトナム)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] 霊長類研究所/生物学研究所/ブラジリア大学(ブラジル)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] 人類学部門/カリフォルニア大学デービス校(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] 教育および心理学部門/アヴェイロ大学(ポルトガル)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] 生理学講座/ベトナム軍医大学(ベトナム)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Gamma oscillations in the superior colliculus and pulvinar in response to faces support discrimination performance in monkeys.2019

    • Author(s)
      Le QV, Nishimaru H, Matsumoto J, Takamura Y, Nguyen MN, Mao CV, Hori E, Maior RS, Tomaz C, Ono T, Nishijo H.
    • Journal Title

      Neuropsychologia

      Volume: - Pages: 87-95

    • DOI

      10.1016/j.neuropsychologia.2017.10.015

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Editorial: Limbic-Brainstem Roles in Perception, Cognition, Emotion, and Behavior.2018

    • Author(s)
      Nishijo H, Rafal R, Tamietto M.
    • Journal Title

      Front. Neurosci.

      Volume: 12 Pages: 395-395

    • DOI

      10.3389/fnins.2018.00395

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Superior Neuronal Detection of Snakes and Conspecific Faces in the Macaque Medial Prefrontal Cortex.2018

    • Author(s)
      Dinh HT, Nishimaru H, Matsumoto J, Takamura Y, Le QV, Hori E, Maior RS, Tomaz C, Tran AH, Ono T, Nishijo H.
    • Journal Title

      Cerebral Cortex

      Volume: in press Issue: 6 Pages: 1-15

    • DOI

      10.1093/cercor/bhx118

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Pregenual anterior cingulate gyrus involvement in spontaneous social interactions in primates - evidence from behavioral, pharmacological, neuropsychiatric, and neurophysiological findings.2017

    • Author(s)
      Mao CV, Araujo MFP, Nishimaru H, Matsumoto J, Tran HA, Hori E, Ono T, Nishijo H.
    • Journal Title

      Front. Neurosci.

      Volume: 11 Pages: 34-34

    • DOI

      10.3389/fnins.2017.00034

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Fast detector/first responder: interactions between the superior colliculus-pulvinar pathway and stimuli relevant to primates.2017

    • Author(s)
      Soares SC, Maior RS, Isbell LA, Tomaz C, Nishijo H.
    • Journal Title

      Front. Neurosci.

      Volume: 11 Pages: 67-67

    • DOI

      10.3389/fnins.2017.00067

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Population coding of facial information in the monkey superior colliculus and pulvinar.2016

    • Author(s)
      Nguyen MN, Nishimaru H, Matsumoto J, Le QV, Hori E, Maior RS, Tomaz C, Ono T, Nishijo H.
    • Journal Title

      Front. Neurosci.

      Volume: 10 Pages: 583-583

    • DOI

      10.3389/fnins.2016.00583

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Distinctive neuronal responses to snake images in the macaque subcortical visual pathway -a fear circuit embedded during primate evolution?-2018

    • Author(s)
      Nishimaru H, Dihn H, Le QV, Matsumoto J, Takamura Y, Ono T, Nishijo H.
    • Organizer
      第95回日本生理学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Phyletic memory embedded in the olfactory and visual systems activates emotion.2018

    • Author(s)
      Nishijo H.
    • Organizer
      第95回日本生理学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Gamma oscillations in the macaque medial prefrontal cortex in response to snakes and conspecific faces.2018

    • Author(s)
      Dinh HT, Nishimaru H, Matsumoto J, Takamura Y, Hori E, Ono T, Nishijo H.
    • Organizer
      第41回日本神経科学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Monkey superior collicular neurons code the timing and the value of the reward.2018

    • Author(s)
      Nishimaru H, Le QV, Matsumoto J, Takamura Y, Hori E, Ono T, Nishijo H.
    • Organizer
      第41回日本神経科学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Role of the extrageniculate visual pathway in innate recognition in primates.2018

    • Author(s)
      Nishijo H, Nishimaru H, Matsumoto J, Takamura Y, Ono T.
    • Organizer
      10th Anokhin's reading, 2018 Jan 23-26. Moscow.
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Neuronal responses to snakes and conspecific faces in the macaque medial prefrontal cortex.2017

    • Author(s)
      Dinh HT, Nishimaru H, Matsumoto J, Takamura Y, Le QV, Hori E, Ono T and Nishijo H.
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      浜松
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] The macaque medial prefrontal cortex neurons respond rapidly and strongly to images of snakes and emotional faces of conspecifics2017

    • Author(s)
      Nishimaru H, Dinh HT, Matsumoto J, Takamura Y, Le QV, Hori E, Ono T, Nishijo H.
    • Organizer
      Neuroscience 2017, 2017 Nov 11-15, Washington, D.C.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Strong and fast neuronal responses to snakes and conspecific faces in the macaque medial prefrontal cortex2017

    • Author(s)
      Dinh HT, Nishimaru H, Matsumoto J, Takamur Y, Le QV, Hori E, Ono T, Nishijo H.
    • Organizer
      第40回日本科学神経大会. 2017 Jul 20-23. 幕張.
    • Related Report
      2017 Annual Research Report
  • [Presentation] ニホンザルの皮質下視覚経路のニューロンはヘビに対して強く素早く応答する.2016

    • Author(s)
      西丸広史,Quan Van Le,Van Quang Le,松本惇平,高村雄策,堀悦郎,小野武年,西条寿夫
    • Organizer
      日本情動学会第6回大会
    • Place of Presentation
      神戸
    • Year and Date
      2016-12-10
    • Related Report
      2016 Annual Research Report
  • [Presentation] サル上丘および視床枕におけるニューロン集団よる顔情報の表現2016

    • Author(s)
      堀 悦郎,Minh Nui Nguyen,西丸広史,松本淳平,高村雄策,小野武年,西条寿夫.
    • Organizer
      日本情動学会第6回大会
    • Place of Presentation
      神戸
    • Year and Date
      2016-12-10
    • Related Report
      2016 Annual Research Report
  • [Presentation] Snakes elicit stronger and early gamma oscillations in the superior colliculus.2016

    • Author(s)
      Le Van Quang,Quan Van Le,Hiroshi Nishimaru,Ha Trong Dinh,Jumpei Matsumoto,Yusaku Takamura,Taketoshi Ono,Hisao Nishijo.
    • Organizer
      第39回日本神経科学学会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Rapid detection of snakes and faces in the monkey superior collicular and pulvinar neurons in the subcortical visual pathway.2016

    • Author(s)
      Nishimaru H, Le QV, Nguyen MN, Matsumoto J, Takamura Y, Ono T, Nishijo H.
    • Organizer
      25th meeting of the International Behavioral Neuroscience Society
    • Place of Presentation
      Budapest, Hungary
    • Year and Date
      2016-06-07
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2022-05-20  

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