Neural mechanisms of detection of biological and temporal salience in primates
| Project/Area Number |
16H04652
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | University of Toyama |
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Principal Investigator |
NISHIJO HISAO 富山大学, 大学院医学薬学研究部(医学), 教授 (00189284)
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| Research Collaborator |
NISHIMARU HIROSHI
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2018: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Keywords | 霊長類 / 上丘 / 内側前頭葉 / 生物学的サリエンス / ヘビ / 顔 / 報酬予測 / 時間的サリエンス / 前内側前頭葉 / 内側前頭皮質 / サリエンス / 内側前頭前野 / 報酬 / 本能 / 注意 / 前頭極 |
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| Outline of Final Research Achievements |
To investigate salience detection mechanisms in primates, we analyzed neuronal responses to visual stimuli in the extrageniculate system (superior colliculus, and pulvinar) as well as the medial frontal cortex that receives anatomical projections from the extrageniculate system in monkeys. The results indicated: 1) the medial frontal cortical neurons receive fast and coarse inputs from the extrageniculate system, and are involved in the detection of stimuli with biological salience (snakes and conspecific faces), and 2) collicular neurons in the deep layers showed climbing activities during the delay intervals before appearance of rewarding stimuli, and are involved in the temporal salience detection mechanisms predicting the emergence of rewarding stimuli.
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| Academic Significance and Societal Importance of the Research Achievements |
我々は様々な感覚刺激を受けるが、これまでと異なる特別な刺激(サリエンスを有する刺激)に注意が喚起される。本研究では、サルを用いてニューロン活動を記録して視覚刺激に対する応答性を解析した結果、1）内側前頭前野は、生物学的サリエンスを有する刺激（天敵であるヘビや同種の顔）の検出に、および2）上丘の深層は、報酬刺激の出現を予測する時間的サリエンスを有する刺激の検出に関与することが明らかになった。
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Gamma oscillations in the superior colliculus and pulvinar in response to faces support discrimination performance in monkeys.2019
Author(s)
Le QV, Nishimaru H, Matsumoto J, Takamura Y, Nguyen MN, Mao CV, Hori E, Maior RS, Tomaz C, Ono T, Nishijo H.
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Journal Title
Neuropsychologia
Volume: －
Pages: 87-95
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Superior Neuronal Detection of Snakes and Conspecific Faces in the Macaque Medial Prefrontal Cortex.2018
Author(s)
Dinh HT, Nishimaru H, Matsumoto J, Takamura Y, Le QV, Hori E, Maior RS, Tomaz C, Tran AH, Ono T, Nishijo H.
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Journal Title
Cerebral Cortex
Volume: in press
Issue: 6
Pages: 1-15
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Pregenual anterior cingulate gyrus involvement in spontaneous social interactions in primates - evidence from behavioral, pharmacological, neuropsychiatric, and neurophysiological findings.2017
Author(s)
Mao CV, Araujo MFP, Nishimaru H, Matsumoto J, Tran HA, Hori E, Ono T, Nishijo H.
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Journal Title
Front. Neurosci.
Volume: 11
Pages: 34-34
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] The macaque medial prefrontal cortex neurons respond rapidly and strongly to images of snakes and emotional faces of conspecifics2017
Author(s)
Nishimaru H, Dinh HT, Matsumoto J, Takamura Y, Le QV, Hori E, Ono T, Nishijo H.
Organizer
Neuroscience 2017, 2017 Nov 11-15, Washington, D.C.
Related Report
Int'l Joint Research
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