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Elucidation of the neural circuits responsible for species-specific sound recognition

Research Project

Project/Area Number 16H04655
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurophysiology / General neuroscience
Research InstitutionNagoya University

Principal Investigator

Kamikouchi Azusa  名古屋大学, 理学研究科, 教授 (00525264)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2019: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Keywords聴覚情報処理 / 聴覚神経回路 / 求愛歌 / 神経科学 / ショウジョウバエ
Outline of Final Research Achievements

Although many animals, including humans, use sound as a means of communication, the overall picture of the neural mechanisms responsible for the information processing has not been clarified. In this study, we used the Drosophila auditory system as an experimental model to understand the neural circuit mechanism for auditory information processing, such as recognizing species-specific communication sounds. We found that the pulse interval-selective response of AMMC-B1 neurons, which are secondary auditory neurons that play a central role in courtship song information processing, is formed by a feed-forward inhibitory pathway that is mainly driven by GABA-mediated inhibitory input.

Academic Significance and Societal Importance of the Research Achievements

聴覚情報として受容される音は、様々な要素によって構成されている。多くの動物で同種認知に用いられる音は、音の高さや長さに加えて、音の時間間隔、という要素でも特徴付けられる。では、音に様々な意味を付加するこの「時間間隔」という要素は、どのように脳内で処理されているのだろうか。本研究では、キイロショウジョウバエにおける脳内処理機構として、フィードフォワード神経回路を介した神経機構が明らかになった。この知見を基にして、他の動物種にも共通する、種特異的な求愛音の情報処理機構の神経基盤の解明が進むことが期待される。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (38 results)

All 2020 2019 2018 2017 2016 Other

All Int'l Joint Research (3 results) Journal Article (11 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 11 results,  Open Access: 7 results) Presentation (23 results) (of which Int'l Joint Research: 9 results,  Invited: 12 results) Book (1 results)

  • [Int'l Joint Research] HHMI Janelia research campus(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Janelia Research Campus(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Janelia Research Campus(米国)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] A Feedforward Circuit Regulates Action Selection of Pre-mating Courtship Behavior in Female Drosophila.2020

    • Author(s)
      Hiroshi Ishimoto,Azusa Kamikouchi
    • Journal Title

      Current biology

      Volume: 30 Issue: 3 Pages: 396-407

    • DOI

      10.1016/j.cub.2019.11.065

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Wiring patterns from auditory sensory neurons to the escape and song-relay pathways in fruit flies.2020

    • Author(s)
      Hyunsoo Kim,Mihoko Horigome,Yuki Ishikawa,Feng Li,J Scott Lauritzen,Gwyneth Card,Davi D Bock,Azusa Kamikouchi
    • Journal Title

      The Journal of comparative neurology

      Volume: 24877 Issue: 12 Pages: 1-31

    • DOI

      10.1002/cne.24877

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 総説 わずかなリズムの違いを聞き分ける脳のしくみ2019

    • Author(s)
      Yamada D,Kamikouchi A
    • Journal Title

      BRAIN and NERVE

      Volume: 71 Issue: 6 Pages: 599-609

    • DOI

      10.11477/mf.1416201322

    • ISSN
      1344-8129, 1881-6096
    • Year and Date
      2019-06-01
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stereotyped Combination of Hearing and Wind/Gravity-sensing Neurons in the Johnston窶冱 Organ of Drosophila.2019

    • Author(s)
      Yuki Ishikawa,Mao Fujiwara,Junlin Wong,Akari Ura,Azusa Kamikouchi
    • Journal Title

      Frontiers in Physiology

      Volume: 10 Pages: 1552-1552

    • DOI

      10.3389/fphys.2019.01552

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] STEFTR: A Hybrid Versatile Method for State Estimation and Feature Extraction From the Trajectory of Animal Behavior.2019

    • Author(s)
      Yamazaki SJ,Ohara K,Ito K,Kokubun N,Kitanishi T,Takaichi D,Yamada Y,Ikejiri Y,Hiramatsu F,Fujita K,Tanimoto Y,Yamazoe-Umemoto A,Hashimoto K,Sato K,Yoda K,Takahashi A,Ishikawa Y,Kamikouchi A,Hiryu S,Maekawa T,Kimura KD
    • Journal Title

      Frontiers in neuroscience

      Volume: 13 Pages: 626-626

    • DOI

      10.3389/fnins.2019.00626

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Softness sensing and learning in Drosophila.2019

    • Author(s)
      Kudow N, Kamikouchi A. & Tanimura T.
    • Journal Title

      Journal of Experiemental Biology

      Volume: 222 Pages: 1-11

    • DOI

      10.1242/jeb.196329

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Single Male Auditory Response Test to Quantify Auditory Behavioral Responses in Drosophila melanogaster2019

    • Author(s)
      Yuki Ishikawa, Natsuki Okamoto, Yusuke Yoneyama, Naoki Maeda, Azusa Kamikouchi
    • Journal Title

      Journal of Neurogenetics

      Volume: 印刷中 Issue: 2 Pages: 64-74

    • DOI

      10.1080/01677063.2019.1611805

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Assessing Experience-dependent Tuning of Song Preference in Fruit Flies (Drosophila melanogaster)2018

    • Author(s)
      Li Xiaodong、Ishimoto Hiroshi、Kamikouchi Azusa
    • Journal Title

      BIO-PROTOCOL

      Volume: 8 Issue: 14

    • DOI

      10.21769/bioprotoc.2932

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] GABAergic local interneurons shape female fruit fly response to mating songs2018

    • Author(s)
      Daichi Yamada, Hiroshi Ishimoto, Xiaodong Li, Tsunehiko Kohashi, Yuki Ishikawa, Azusa Kamikouchi
    • Journal Title

      The Journal of Neuroscience

      Volume: 印刷中 Issue: 18 Pages: 4329-4347

    • DOI

      10.1523/jneurosci.3644-17.2018

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Auditory experience controls the maturation of song discrimination and sexual response in Drosophila2018

    • Author(s)
      Xiaodong Li, Hiroshi Ishimoto, Azusa Kamikouchi
    • Journal Title

      eLife

      Volume: 7

    • DOI

      10.7554/elife.34348

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Anatomic and Physiologic Heterogeneity of Subgroup-A Auditory Sensory Neurons in Fruit Flies2017

    • Author(s)
      Ishikawa Yuki、Okamoto Natsuki、Nakamura Mizuki、Kim Hyunsoo、Kamikouchi Azusa
    • Journal Title

      Frontiers in Neural Circuits

      Volume: 11 Pages: 46-46

    • DOI

      10.3389/fncir.2017.00046

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Serotonergic neurons modulate the temporal dynamics of the auditory response behavior induced by a courtship song in the fruit fly2019

    • Author(s)
      Nao Morimoto, Ryosuke F. Takeuchi, Ayano Ishida, Azusa Kamikouchi, Fumitaka Osakada
    • Organizer
      Neuro 2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] Evolution of neural circuit for chemical communication in縲?Drosophila2019

    • Author(s)
      Yuki Ishikawa,Naoki Maeda,Azusa Kamikouchi
    • Organizer
      Neuro 2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] Neural mechanism for evaluating love songs in fruit flies2019

    • Author(s)
      Azusa Kamikouchi
    • Organizer
      17th International Meeting on Invertebrate Sound and Vibration
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 性フェロモン選好性の進化的逆転をもたらす神経基盤2019

    • Author(s)
      石川由希、前田直希、上川内あづさ
    • Organizer
      日本進化学会第21回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Presynaptic regulation of auditory sensory neurons in fruit flies2019

    • Author(s)
      上川内あづさ
    • Organizer
      第12回分子高次機能研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ショウジョウバエの歌受容を調節する抑制性神経伝達2019

    • Author(s)
      上川内あづさ
    • Organizer
      第92回日本生化学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Combination of sensory stimuli modifies the following strategy of the courting male fly (D. melanogaster)2019

    • Author(s)
      高市大輔、石川由希、上川内あづさ
    • Organizer
      日本比較生理生化学会 第41回東京大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Search for auditory neurons that shape song selectivity in two Drosophila species2019

    • Author(s)
      大橋拓朗、石川由希、粟崎健、上川内あづさ
    • Organizer
      日本比較生理生化学会 第41回東京大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Neural mechanism underlying acoustic communication in fruit flies2019

    • Author(s)
      Azusa Kamikouchi
    • Organizer
      6th Annual Meeting of the Society for Bioacoustics
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Neural mechanism of fruit flies to detect the courtship song2019

    • Author(s)
      Azusa Kamikouchi
    • Organizer
      5th Tokyo Vector Encounter
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Organization of the auditory system in fruit flies2018

    • Author(s)
      Azusa Kamikouchi
    • Organizer
      The International Congress of Neuroethology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Auditory experience controls the maturation of song discrimination in fruit flies2018

    • Author(s)
      Azusa Kamikouchi
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Auditory sensory neurons that interact with the escape and courtship circuits in flies2018

    • Author(s)
      Azusa Kamikouchi
    • Organizer
      The 12th Japanese Drosophila Research Conference
    • Related Report
      2018 Annual Research Report
  • [Presentation] 音経験に応じて成熟するショウジョウバエの「歌受容システム」2018

    • Author(s)
      上川内あづさ
    • Organizer
      第91回日本生化学会大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 聴覚システムの構造と機能2018

    • Author(s)
      上川内あづさ
    • Organizer
      昆虫脳コネクトーム研究の最前
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] ショウジョウバエ聴覚系の神経解剖学2018

    • Author(s)
      上川内あづさ
    • Organizer
      第123回日本解剖学会総会・日本学術総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Experience-dependent tuning of the auditory behavior in Drosophila2017

    • Author(s)
      Li Xiaodong, Azusa Kamikouchi
    • Organizer
      The 4th Asia-Pacific Dorosophila Research Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 求愛歌受容を担うショウジョウバエの聴覚システム2017

    • Author(s)
      上川内あづさ
    • Organizer
      第89回日本遺伝学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Auditory neural circuits in the fly brain2017

    • Author(s)
      Azusa Kamikouchi
    • Organizer
      From sender to receiver: physics and sensory ecology of hearing in insects and vertebrates
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Early auditory experience shapes the auditory response in fruit flies (Drosophila melanogaster)2017

    • Author(s)
      Azusa Kamikouchi
    • Organizer
      日本比較生理生化学会第39回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Mapping the auditory neurons in the fly brain2017

    • Author(s)
      Azusa Kamikouchi
    • Organizer
      Full Adult Fly Brain Tracers’ Workshop
    • Place of Presentation
      Janelia Research Campus(USA)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Auditory neural circuits in the brain of the fruit fly2016

    • Author(s)
      Azusa Kamikouchi
    • Organizer
      第22回国際動物学会, 第87回日本動物学会(同時開催)
    • Place of Presentation
      沖縄コンベンションセンター
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Quantification of sound discrimination ability in fruit fly2016

    • Author(s)
      Yuki Ishikawa, Azusa Kamikouchi
    • Organizer
      第22回国際動物学会, 第87回日本動物学会(同時開催)
    • Place of Presentation
      沖縄コンベンションセンター
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Book] 遺伝子から解き明かす脳の不思議な世界2018

    • Author(s)
      2.上川内あづさ、石川由希
    • Total Pages
      520
    • Publisher
      一式出版
    • ISBN
      9784909383051
    • Related Report
      2018 Annual Research Report

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Published: 2016-04-21   Modified: 2022-01-28  

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