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Functional analysis of tactile reception

Research Project

Project/Area Number 16H04657
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurophysiology / General neuroscience
Research InstitutionAoyama Gakuin University

Principal Investigator

Hirata Hiromi  青山学院大学, 理工学部, 教授 (60402450)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2018: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Keywords遺伝学 / 触覚
Outline of Final Research Achievements

Using the motor system of zebrafish as a model, we searched for molecules related to mechanoreception. We identified a membrane protein that is likely involved in mechanoreception. We also intended to construct an experimental system for quantitative analysis of zebrafish swimming and established a swimmill that measures the maximum speed of fish swimming. Using this system, we analyzed the swimming ability of zebrafish and found that there is no gender difference in swimming ability and that the swimming ability is maximized when the length of the tail fin is 5 mm. There are several genetically different zebrafish lines established in laboratories. We compared swimming ability of several lines and revealed that the WIK line is less capable of swimming and this trait is inherited to offspring.

Academic Significance and Societal Importance of the Research Achievements

物に触れた時に感じる感覚を触角という。触覚は視覚、聴覚、嗅覚、味覚とならぶ五感の一つとして紀元前から知られるが、どうやって触覚を感じるか、具体的には触覚の受容体やその他の細胞内分子の実体については他の感覚と比べて未解明のことが多く残されている。これを解明する目的でゼブラフィッシュの運動をモデルとした触覚の研究を行い、触覚を感じるのに必要な分子を探索し、触覚を感じるのに必要なタンパク質を同定した。このタンパク質は細胞膜上にあると考えており、この分子の理解から、触覚異常をともなうさまざまな疾患の理解が深まると期待される。また、ゼブラフィッシュの運動を計測し、運動能力が遺伝形質であることを確認した。

Report

(4 results)
  • 2019 Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (12 results)

All 2019 2018 2017 2016

All Journal Article (8 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 8 results,  Open Access: 6 results,  Acknowledgement Compliant: 2 results) Presentation (3 results) (of which Invited: 3 results) Book (1 results)

  • [Journal Article] Phosphorylation of gephyrin in zebrafish Mauthner cells governs glycine receptor clustering and behavioral desensitization to sound2019

    • Author(s)
      Kazutoyo Ogino, Kenta Yamada, Tomoki Nishioka, Yoichi Oda, Kozo Kaibuchi and Hiromi Hirata
    • Journal Title

      Journal of Neuroscience

      Volume: 39 Issue: 45 Pages: 8988-8997

    • DOI

      10.1523/jneurosci.1315-19.2019

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Swimming capability of zebrafish is governed by water temperature, caudal fin length and genetic background.2019

    • Author(s)
      Wakamatsu, Y., Ogino, K. and Hirata, H.
    • Journal Title

      Sci. Rep.

      Volume: 9 Issue: 1 Pages: 16307-16307

    • DOI

      10.1038/s41598-019-52592-w

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rap1b promotes Notch signal-mediated hematopoietic stem cell development by enhancing integrin-mediated cell adhesion.2019

    • Author(s)
      Rho S., Kobayashi I., Oguri-Nakamura E., Ando K., Fujiwara M., Kamimura N., Hirata H., Iida A., Iwai Y., Mochizuki N., Fukuhara S.
    • Journal Title

      Developmental Cell

      Volume: 印刷中 Issue: 5 Pages: 1-16

    • DOI

      10.1016/j.devcel.2019.03.023

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The AAA+ ATPase/ubiquitin ligase mysterin stabilizes cytoplasmic lipid droplets2019

    • Author(s)
      Munechika Sugihara, Daisuke Morito, Shiori Ainuki, Yoshinobu Hirano, Kazutoyo Ogino, Akira Kitamura, Hiromi Hirata, Kazuhiro Nagata
    • Journal Title

      Journal of Cell Biology

      Volume: 218 Issue: 3 Pages: 949-960

    • DOI

      10.1083/jcb.201712120

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Deleterious de novo variants of X-linked ZC4H2 in females cause a variable phenotype with neurogenic arthrogryposis multiplex congenita.2019

    • Author(s)
      Frints, S. G. M. et al.
    • Journal Title

      Hum. Mutat.

      Volume: 40 Issue: 12 Pages: 2270-2285

    • DOI

      10.1002/humu.23841

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Functional consequence of the postnatal switch from neonatal to mutant adult glycine receptor a1 subunits in the shaky mouse model of startle disease.2018

    • Author(s)
      Schaefer, N., Zheng, F., van Brederode, H., Berger, A., Leacock, S., Hirata, H., Paige, C. J., Harvey, R. J. Alzheimer, C. and Villmann, C.
    • Journal Title

      Front. Mol. Neurosci.

      Volume: 11 Pages: 167-167

    • DOI

      10.3389/fnmol.2018.00167

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Activation-dependent rapid postsynaptic clustering of glyicine receptors in mature spinal cord neurons2017

    • Author(s)
      Nakahata Y, Eto K, Murakoshi H, Watanabe M, Kuriu T, Hirata H, Moorhouse AJ, Ishibashi H, Nabekura J
    • Journal Title

      eNeuro

      Volume: 0194 Issue: 1 Pages: 1-20

    • DOI

      10.1523/eneuro.0194-16.2017

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Defects of the Glycinergic Synapse in Zebrafish2016

    • Author(s)
      Kazutoyo Ogino, Hiromi Hirata
    • Journal Title

      Frontiers in Molecular Neuroscience

      Volume: 9 Pages: 286-286

    • DOI

      10.3389/fnmol.2016.00050

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] ゼブラフィッシュを用いた骨格筋の形成・維持の研究およびその破綻による疾患2019

    • Author(s)
      平田普三
    • Organizer
      第74回日本体力医学会大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] ゼブラフィッシュを用いたカルシウム動態制御と筋疾患の研究2018

    • Author(s)
      平田普三
    • Organizer
      第4回日本筋学会学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] グリシン作動性シナプスの可塑性による動物の環境適応2017

    • Author(s)
      平田普三
    • Organizer
      次世代脳プロジェクト冬のシンポジウム2017
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Book] Zebrafish, Medaka, and Other Small Fishes: New Model Animals in Biology, Medicine, and Beyond2018

    • Author(s)
      Hirata H and Iida A (Ed)
    • Total Pages
      315
    • Publisher
      Springer
    • ISBN
      9789811318788
    • Related Report
      2017 Annual Research Report

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Published: 2016-04-21   Modified: 2021-02-19  

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