Regulation of brain functions by phagocytic astrocytes

• Project/Area Number: 16H04669
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: University of Yamanashi
• Principal Investigator: KOIZUMI Schuichi 山梨大学, 大学院総合研究部, 教授 (10280752)
• Co-Investigator(Kenkyū-buntansha): 繁冨 英治 山梨大学, 大学院総合研究部, 助教 (00631061)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000); Fiscal Year 2018: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2016: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
• Keywords: アストロサイト / 貪食 / シナプス再編 / 神経ネットワーク再編 / 脳卒中 / ミクログリア / ABCA1 / 神経機能 / リモデリング / 神経科学 / 脳・神経 / 脳神経疾患 / 薬理学

Outline of Final Research Achievements

The importance of glial cells in neural network remodeling has been pointed out. Astrocytes, a type of glial cells, acquire phagocytosis after stroke, prune synapses, and play a central role in neural network remodeling, according to a new study. Early after stroke, microglia accumulate in the center of the infarct layer (core region) and remove dead cells and their fragments from the brain by phagocytosis. On the other hand, in the periphery of the infarct layer (penumbra region), astrocytes were activated and acquired phagocytosis, reaping weakened synapses by phagocytosis and building new neural networks. We also found that astrocytes were altered to be phagocytic by increasing the expression of ABCA1.

Academic Significance and Societal Importance of the Research Achievements

脳機能変化は、シナプス再編により神経ネットワークが繋ぎ変わることで実現する。これまでシナプス再編は、神経細胞の自律性により制御されると考えられてきたが、グリア細胞の役割を明らかとした。脳卒中直後は主にミクログリアが、脳卒中後期には特に梗塞層の周辺部位でアストロサイトが貪食によりシナプスを刈込み、神経ネットワーク再編を行うことを明らかにした。また、アストロサイトの貪食を規定する分子として、ABCA1を見いだした。これらは、アストロサイトを上手に制御することで、神経ネットワーク再編、ひいては脳機能を制御する新しい戦略に繋がる重要な知見である。

Research Products

• [Journal Article] Evaluation of M1-microglial activation by neurotoxic metals using optimized organotypic cerebral slice cultures (2019)
  • Author(s): Hoshi T, Toyama T, Shinozaki Y, Koizumi S, Lee JY, Naganuma A, Hwang GW.
  • Journal Title: The Journal of Toxicological Sciences Volume: 44 Issue: 7 Pages: 471-479
  • DOI: 10.2131/jts.44.471
  • NAID: 130007674444
  • ISSN: 0388-1350, 1880-3989
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Microglial ROCK is essential for chronic methylmercury-induced neurodegeneration. (2019)
  • Author(s): Shinozaki Y, Danjo Y, Koizumi S
  • Journal Title: J Neurochemistry Volume: 151 Issue: 1 Pages: 64-78
  • DOI: 10.1111/jnc.14817
  • Peer Reviewed / Open Access
• [Journal Article] Intermittent restraint stress induces circadian misalignment in the mouse bladder, leading to nocturia. (2019)
  • Author(s): Ihara T, Nakamura Y, Mitsui T, Tsuchiya S, Kanda M, Kira S, Nakagomi H, Sawada N, Kamiyama M, Shigetomi E, Shinozaki Y, Yoshiyama M, Nakao A, Koizumi S, Takeda M.
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 10069-10069
  • DOI: 10.1038/s41598-019-46517-w
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Snake venom rhodocytin induces plasma extravasation via toxin-mediated interactions between platelets and mast cells (2019)
  • Author(s): Y. Nakamura, T. Sasaki, C. Mochizuki, K. Ishimaru, S. Koizumi, H. Shinmori, K. Suzuki-Inoue, A. Nakao
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 15958-15958
  • DOI: 10.1038/s41598-019-52449-2
  • Peer Reviewed / Open Access
• [Journal Article] New roles of reactive astrocytes in the brain; an organizer of cerebral ischemia. (2018)
  • Author(s): Koizumi, S., Hirayama, Y., Morizawa, YM
  • Journal Title: Neurochem Int Volume: in press Pages: 107-114
  • DOI: 10.1016/j.neuint.2018.01.007
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Anti-depressant fluoxetine reveals its therapeutic effects via astrocytes. (2018)
  • Author(s): M. Kinoshita, Y. Hirayama, K. Fujishita, K Shibata, Y. Shinozaki, E. Shigetomi, A. Takeda, HP Ngoc Le, H. Hayashi, M. Hiasa, Y. Moriyama, K. Ikenaka, KF Tanaka, S. Koizumi.
  • Journal Title: EBioMedicine Volume: 32 Pages: 72-83
  • DOI: 10.1016/j.ebiom.2018.05.036
  • NAID: 130007901327
  • Peer Reviewed / Open Access
• [Journal Article] The oscillation of intracellular Ca2+ influx associated with the circadian expression of Piezo1 and TRPV4 in the bladder urothelium (2018)
  • Author(s): Ihara Tatsuya、Mitsui Takahiko、Nakamura Yuki、Kanda Mie、Tsuchiya Sachiko、Kira Satoru、Nakagomi Hiroshi、Sawada Norifumi、Kamiyama Manabu、Hirayama Yuri、Shigetomi Eiji、Shinozaki Youichi、Yoshiyama Mitsuharu、Nakao Atsuhito、Takeda Masayuki、Koizumi Schuichi
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 5699-5699
  • DOI: 10.1038/s41598-018-23115-w
  • Peer Reviewed / Open Access
• [Journal Article] The time-dependent variation of ATP release in mouse primary cultured urothelial cells is regulated by the Clock gene. (2018)
  • Author(s): Ihara T, Mitsui T, Nakamura Y, Kanda M, Tsuchiya S, Kira S, Nakagomi H, Sawada N, Kamiyama M, Hirayama Y, Shigetomi E, Shinozaki Y, Yoshiyama M, Nakao A, Takeda M Koizumi S
  • Journal Title: Neurourology and urodynamics Volume: 37 Issue: 8 Pages: 2535-2543
  • DOI: 10.1002/nau.23793
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Neuroprotective effects of microglial P2Y1 receptors against ischemic neuronal injury. (2018)
  • Author(s): Fukumoto, Y., Tanaka, KF., Parajuli, B., Shibata, K., Yoshioka, H., Kanemaru, K., Gachet, C., Ikenaka, K., Koizumi, S. Kinouchi, H.
  • Journal Title: J Cereb Blood FloTakew Metab, Volume: - Issue: 11 Pages: 2144-2156
  • DOI: 10.1177/0271678x18805317
  • Peer Reviewed / Open Access
• [Journal Article] Microglia mediate non-cell-autonomous cell death of retinal ganglion cells. (2018)
  • Author(s): Takeda A, Shinozaki Y, Kashiwagi K, Ohno N, Eto K, Wake H, Nabekura J, Koizumi S.
  • Journal Title: Glia Volume: 66 Issue: 11 Pages: 2366-2384
  • DOI: 10.1002/glia.23475
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Involvement of VNUT-exocytosis in transient receptor potential vanilloid 4-dependent ATP release from gastrointestinal epithelium. (2018)
  • Author(s): Mihara, H., Uchida, K., Koizumi, S., Moriyama, Y
  • Journal Title: PloS One Volume: 13(10) Issue: 10 Pages: e0206276-e0206276
  • DOI: 10.1371/journal.pone.0206276
  • Peer Reviewed / Open Access
• [Journal Article] Role of Purinergic Receptor P2Y1 in Spatiotemporal Ca2+ Dynamics in Astrocytes. (2018)
  • Author(s): Shigetomi E, Hirayama YJ, Ikenaka K, Tanaka KF, Koizumi S.
  • Journal Title: The Journal of Neuroscience Volume: 38 Issue: 6 Pages: 1053-1067
  • DOI: 10.1523/jneurosci.2625-17.2017
  • Peer Reviewed / Open Access
• [Journal Article] Aberrant astrocyte Ca2+ signals “AxCa signals” exacerbate pathological alterations in an Alexander disease model (2018)
  • Author(s): Saito Kozo、Shigetomi Eiji、Yasuda Rei、Sato Ryuichi、Nakano Masakazu、Tashiro Kei、Tanaka Kenji F.、Ikenaka Kazuhiro、Mikoshiba Katsuhiko、Mizuta Ikuko、Yoshida Tomokatsu、Nakagawa Masanori、Mizuno Toshiki、Koizumi Schuichi
  • Journal Title: Glia Volume: 66 Issue: 5 Pages: 1053-1067
  • DOI: 10.1002/glia.23300
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Astrocyte-mediated synapse remodeling in the pathological brain (2017)
  • Author(s): Kim Sun Kwang、Nabekura Junichi、Koizumi Schuichi
  • Journal Title: Glia Volume: 65 Issue: 11 Pages: 1719-1727
  • DOI: 10.1002/glia.23169
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Transformation of Astrocytes to a Neuroprotective Phenotype by Microglia via P2Y1 Receptor Downregulation. (2017)
  • Author(s): Shinozaki Y, Shibata K, Yoshida K, Shigetomi E, Gachet C, Ikenaka K, Tanaka KF, Koizumi S.
  • Journal Title: Cell Rep Volume: 19 Issue: 6 Pages: 1151-1164
  • DOI: 10.1016/j.celrep.2017.04.047
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway (2017)
  • Author(s): Morizawa Yosuke M.、Hirayama Yuri、Ohno Nobuhiko、Shibata Shinsuke、Shigetomi Eiji、Sui Yang、Nabekura Junichi、Sato Koichi、Okajima Fumikazu、Takebayashi Hirohide、Okano Hideyuki、Koizumi Schuichi
  • Journal Title: Nature Communications Volume: 8 Issue: 1 Pages: 28-28
  • DOI: 10.1038/s41467-017-00037-1
  • Peer Reviewed / Open Access
• [Journal Article] Purinergic dysregulation causes hypertensive glaucoma-like optic neuropathy. (2017)
  • Author(s): Shinozaki Y, Kashiwagi K, Namekata K, Takeda A, Ohno N, Robaye B, Harada T, Iwata T, *Koizumi S
  • Journal Title: JCI Insight Volume: 2 Issue: 19
  • DOI: 10.1172/jci.insight.93456
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Hypoxia-independent mechanisms of HIF-1α expression in astrocytes after ischemic preconditioning. (2017)
  • Author(s): Hirayama, Y., Koizumi, S.
  • Journal Title: Glia. Volume: 65 Issue: 3 Pages: 523-530
  • DOI: 10.1002/glia.23109
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Carbenoxolone inhibits TRPV4 channel-initiated oxidative urothelial injury and ameliorates cyclophosphamide-induced bladder dysfunction (2017)
  • Author(s): Zhang X,Gao S,Tanaka M,Zhanq Z,Huanq Y,Mitsui T,Kamiyama M,Koizumi S,Fan J,Takeda M,Yao J
  • Journal Title: J Cell Mol Med Volume: 2017 Issue: 9 Pages: 346-346
  • DOI: 10.1111/jcmm.13100
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Cortical astrocytes rewire somatosensory cortical circuits for peripheral neuropathic pain. (2016)
  • Author(s): Kim SK, Hayashi H, Ishikawa T, Shibata K, Shigetomi E, Shinozaki Y, Inada H, Roh SE, Kim SJ, Lee G, Bae H, Moorhouse AJ, Mikoshiba K, Fukazawa Y, Koizumi S, Nabekura J.
  • Journal Title: J Clin Invest Volume: 126(5) Issue: 5 Pages: 1983-1997
  • DOI: 10.1172/jci82859
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Microglia contact induces synapse formation in developing somatosensory cortex. (2016)
  • Author(s): Miyamoto A， Wake H， Ishikawa AW， Eto K， Shibata K， Murakoshi H， Koizumi S， Moorhouse AJ， Yoshimura Y， Nabekura J
  • Journal Title: Nature Communications Volume: 7 Issue: 1 Pages: 1-12
  • DOI: 10.1038/ncomms12540
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The Clock mutant mouse is a novel experimental model for nocturia and nocturnal polyuria. (2016)
  • Author(s): Ihara, T., Mitsui, T., Nakamura, Y., Kira, S., Miyamoto, T., Nakagomi, H., Sawada, N., Hirayama, Y., Shibata, K., Shigetomi, E., Shinozaki, Y., Yoshiyama, M., Nakao, A., *Takeda, M. *Koizumi, S.
  • Journal Title: Neurourology and Urodynamics Volume: 36 Issue: 4 Pages: 1034-1038
  • DOI: 10.1002/nau.23062
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Urothelial ATP exocytosis: regulation of bladder compliance in the urine storage phase (2016)
  • Author(s): Nakagomi H,Yoshiyama M,Mochizuki T,Miyamoto T,Komatsu R,Imura Y,Morizawa Y,Hiasa M,Kira S,Fujishita K,Shibata K,Shigetomi E,Shinozaki Y,Takeda M,Koizumi S
  • Journal Title: Scientific Reports Volume: 6 Issue: 1 Pages: 29761-29761
  • DOI: 10.1038/srep29761
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] An effective therapeutic approach for oxaliplatin-induced peripheral neuropathy using combination therapy with Goshajinkigan and Bushi. (2016)
  • Author(s): Mizuno, K., Shibata, K., Komatsu, R., Omiya, Y., Kase, Y. and *Koizumi, S.
  • Journal Title: Cancer Biol Ther Volume: 17 Pages: 1206-1212
  • Peer Reviewed / Int'l Joint Research
• [Presentation] グリアからみた発現メカニズム～生化学的アプローチ～ (2019)
  • Author(s): 小泉修一
  • Organizer: Glutamate Conference
  • Invited
• [Presentation] Reappearance of astrocytic mGluR5 assembles cortical networks in induction of neuropathic pain. (2019)
  • Author(s): Danjo, Y., Hirayama, YJ, Shigetomi, E., Shibata, K., Takanashi, K., Shinozaki, Y., Kim, SK, Nabekura, J., Koizumi, S.
  • Organizer: 第92回日本薬理学会年会
• [Presentation] Glial purinergic signals as a target for antidepressants. (2019)
  • Author(s): Koizumi, S.
  • Organizer: 第92回日本薬理学会年会
  • Invited
• [Presentation] Monitoring bidirectional information processing between neurons and astrocyte. (2019)
  • Author(s): Shigetomi, E., Koizumi, S
  • Organizer: 第92回日本薬理学会年会
• [Presentation] Synapse remodeling by astrocytes (2019)
  • Author(s): Koizumi, S
  • Organizer: ケベック大学カンファレンス
  • Int'l Joint Research / Invited
• [Presentation] Role of calcium signals in reactive astrocytes. (2019)
  • Author(s): Shigetomi, E
  • Organizer: ケベック大学カンファレンス
  • Int'l Joint Research
• [Presentation] グリアによる一次体性感覚野のシナプス再編 (2019)
  • Author(s): 小泉修一
  • Organizer: 第7回神経と免疫を語る会
  • Invited
• [Presentation] Bidirectional regulation of synapse remodeling by reactive astrocytes (2019)
  • Author(s): Koizumi, S
  • Organizer: FAOPS2019
  • Int'l Joint Research / Invited
• [Presentation] Visualization of spatiotemporal interaction of neurons and astrocytes. (2019)
  • Author(s): Shigetomi, E., Hirayama, JY., Ikenaka, K., Tanaka, FK., Bito, H., Koizumi, S.
  • Organizer: FAOPS2019
  • Int'l Joint Research
• [Presentation] アストロサイト性シナプス再編 (2018)
  • Author(s): 小泉修一、檀上洋右、鍋倉淳一
  • Organizer: 第2回感覚免疫学研究会
  • Invited
• [Presentation] Ischemic tolerance and glial purinergic signaling. (2018)
  • Author(s): Koizumi, S
  • Organizer: Purines2018
  • Int'l Joint Research / Invited
• [Presentation] Astrocyte-synapse interaction in health and diseases. (2018)
  • Author(s): Koizumi, S
  • Organizer: WCP2018
  • Int'l Joint Research / Invited
• [Presentation] Dynamic interaction of neurons and astrocytes revealed dual color Ca2+ imaging. (2018)
  • Author(s): Shigetomi, E., Hirayama, Y., Ikenaka, K., Tanaka, FK, Bito, H., Koizumi, S.
  • Organizer: WCP2018
  • Int'l Joint Research
• [Presentation] Remodeling the brain after stroke by astrocytic phagocytosis. (2018)
  • Author(s): Morizawa, Y., Koizumi, S
  • Organizer: WCP2018
  • Int'l Joint Research
• [Presentation] An essential role of astrocytic mGluR5 in the somatosensory cortex in regulation of synaptogenesis and neuropathic pain. (2018)
  • Author(s): Danjo, Y., Hirayama, Y., Shigetomi, E., Shibata, K., Takanashi, K., Shinozaki, Y., Kim, SK, Nabekura, J., Koizumi, S
  • Organizer: WCP2018
  • Int'l Joint Research
• [Presentation] グリア細胞による脳リモデリング (2018)
  • Author(s): 小泉修一
  • Organizer: 第48回新潟神経学夏期セミナー
  • Invited
• [Presentation] Astrocyte-dependent brain remodeling. (2018)
  • Author(s): Koizumi, S
  • Organizer: 第41回日本神経科学大会
  • Invited
• [Presentation] Role of microglia in astrogliopahty: a study of Alexander disease model (2018)
  • Author(s): Shigetomi, E., Kobayashi, K., Saito, K., Koizumi, S.
  • Organizer: 第61回日本神経化学会大会
• [Presentation] Astrocyte-mediated network remodeling. (2018)
  • Author(s): Koizumi S
  • Organizer: 第61回日本神経化学会大会
  • Invited
• [Presentation] Reappearance of astricytic mGluR5 in the primary somatosensory cortex is a cause of neuropathic pain - reassembles of cortical networks (2018)
  • Author(s): Danjo, Y., Hirayama, Y., Shigetomi, E., Shibata, K., Takanashi, K., Shinozaki, Y., Kim, SK., Nabekura, J., Koizumi, S.
  • Organizer: 第61回日本神経化学会大会
• [Presentation] A new role of astrocytes in regulation of brain function by ABCA1. (2018)
  • Author(s): Koizumi S., Morizawa, Y.
  • Organizer: 第91回日本生化学会大会
  • Invited
• [Presentation] Bidirectional synapse remodeling by reactive astrocytes. (2018)
  • Author(s): Koizumi S
  • Organizer: YoungGlia glial heterogeneity meeting
  • Int'l Joint Research / Invited
• [Presentation] 脳虚血耐性におけるアストロサイトP2X7受容体活性化メカニズムの解析 (2018)
  • Author(s): 平山友里、石井伊都子、安西尚彦、小泉修一
  • Organizer: 第139回日本薬理学会関東部会
• [Presentation] VNUT-mediated microglia ATP excytosis contributes to Neuroprotection in the ischemic brain. (2018)
  • Author(s): Ngoc, Le HP., Hirayama, Y., Tanaka, FK., Koizumi, S
  • Organizer: 2018 Cold Spring Harbor Asia Conference.
  • Int'l Joint Research
• [Presentation] Reactive astrocyte-mediated synapse remodeling. (2018)
  • Author(s): Koizumi, S.
  • Organizer: 2018 Cold Spring Harbor Asia Conference
  • Int'l Joint Research / Invited
• [Presentation] A network remodeling by reactive astrocytes. (2018)
  • Author(s): Koizumi, S.
  • Organizer: The Glia Section of The Korean Society for Brain and Neural Sciences.
  • Int'l Joint Research / Invited
• [Presentation] グリア細胞による神経障害性疼痛アロディニア誘導メカニズム (2018)
  • Author(s): 小泉修一
  • Organizer: 第1回Hz-S フォーラム
  • Int'l Joint Research
• [Presentation] A new role of reactive astrocytes; a network remodeling. (2018)
  • Author(s): Koizumi, S
  • Organizer: 第1回山梨大学先端脳科学特別教育プログラム国際シンポジウム
  • Int'l Joint Research
• [Presentation] 貪食性アストロサイトによる神経回路リモデリング (2018)
  • Author(s): 小泉修一、森澤陽介、平山友里
  • Organizer: 第138回日本薬理学会関東部会
• [Presentation] 一次体性感覚野のATP増加がアストロサイト性シナプス再編及び機械的アロディニアを引き起こす (2017)
  • Author(s): 柴田圭輔、久保田啓太、石川達也、篠崎陽一、繁冨英治、御子柴克彦、鍋倉淳一、小泉修一
  • Organizer: 第90回日本薬理学会年会
  • Place of Presentation: 長崎ブリックホール（長崎県・長崎市）
  • Year and Date: 2017-03-16
• [Presentation] Cortical synaptic remodeling by astrocytes (2017)
  • Author(s): Koizumi, S
  • Organizer: The 3rd Symposium of NeuroScience Network in Kobe.
  • Place of Presentation: （兵庫県・神戸市）
  • Year and Date: 2017-02-17
  • Invited
• [Presentation] アストロサイトによる体性感覚野神経回路の組み替えと慢性疼痛 (2017)
  • Author(s): 小泉修一
  • Organizer: 北陸大学グリアセミナー
  • Place of Presentation: 北陸大学（石川県・金沢市）
  • Year and Date: 2017-02-15
  • Invited
• [Presentation] Glia-Mediated Eplileptogenicity. (2017)
  • Author(s): Koizumi, S
  • Organizer: The 5th congress of AsCNP.
  • Int'l Joint Research
• [Presentation] ミクログリアは脳傷害後の神経保護的アストロサイトを誘導する (2017)
  • Author(s): 篠崎陽一、柴田圭輔、吉田慶太郎、繁冨英治、田中謙二、小泉修一
  • Organizer: 第136回日本薬理学会関東部会
• [Presentation] Cortical astrocytes rewire somatosensory cortical circuits for peripheral neuropathic pain (2017)
  • Author(s): Koizumi, S., Kim, S, K., Nabekura, J
  • Organizer: ⅩⅢ EUROPEAN Meeting on Glial Cells in Health and Disease
  • Int'l Joint Research
• [Presentation] アストロサイトCa2+シグナルの時空間ダイナミクスの多様性と脳機能制御 (2017)
  • Author(s): 繁冨英治
  • Organizer: 日本大学歯学部セミナー
  • Invited
• [Presentation] When do astrocytes listen to ATP derived from neurons? (2017)
  • Author(s): Shigetomi, E., Hirayama, Y., Sano, F., Koizumi, S.
  • Organizer: 第40回日本神経科学大会
• [Presentation] Astrocytes mediate synaptic rewiring. (2017)
  • Author(s): Koizumi, S., Shibata, K., Kim, S, K., Nabekura, J
  • Organizer: 第40回日本神経科学大会
• [Presentation] グリア性虚血耐性とその分子メカニズム (2017)
  • Author(s): 小泉修一、平山友里
  • Organizer: 第18回日本分子脳神経外科学会
• [Presentation] Glia-mediated ischemic tolerance. (2017)
  • Author(s): Hirayama, Y., Koizumi, S
  • Organizer: 第60回日本神経化学会大会
• [Presentation] Microglia-induced astrocytic P2Y1 receptor down-regulation causes astrocyte scar formation (2017)
  • Author(s): Shinozaki, Y., Shibata, K., Shigetomi, E., Yoshida, K., Ikenaka, K., Tanaka, F, K., Koizumi, S
  • Organizer: 第60回日本神経化学会大会
• [Presentation] Phagocytic astrocytes after brain ischemia (2017)
  • Author(s): Morizawa, Y., Koizumi, S.
  • Organizer: 第60回日本神経化学会大会
• [Presentation] Epileptogenic astrocytes. (2017)
  • Author(s): Koizumi, S
  • Organizer: 第60回日本神経化学会大会
• [Presentation] グリア細胞による神経回路リモデリング (2017)
  • Author(s): 小泉修一
  • Organizer: 第19回応用薬理シンポジウム
  • Invited
• [Presentation] ミクログリアはアストロサイトのP2Y1受容体発現低下を介して神経保護機能を誘導する (2017)
  • Author(s): 篠崎陽一、柴田圭輔、吉田慶太郎、繁冨英治、田中謙二、小泉修一
  • Organizer: 第39回日本生物学的精神医学会・第47回日本神経精神薬理学会合同年会
• [Presentation] アストロサイトによる神経ネットワーク再構築と疾患 (2017)
  • Author(s): 小泉修一
  • Organizer: 千里ライフサイエンスセミナーL3
  • Invited
• [Presentation] Rewiring of Neuronal Networks by Astrocytic Ca2+ in the Somatosensory Cortex. (2017)
  • Author(s): Koizumi, S
  • Organizer: 20th International Symposium on Calcium Binding Proteins and Calcium Function I Health and Disease.(CaBP20)
  • Int'l Joint Research / Invited
• [Presentation] アストロサイト微細突起Ca2+シグナルにおけるP2Y1受容体の役割 (2017)
  • Author(s): 繁冨英治、平山幸歩、小泉修一
  • Organizer: 第137回日本薬理学会関東部会
• [Presentation] Mechanism underlying hypoxia-independent upregulation of adtrocytic HIF-α after ischemic preconditioning. (2017)
  • Author(s): Hirayama, Y., H. P. N. LE., Koizumi, S.
  • Organizer: Neuroscience2017
  • Int'l Joint Research
• [Presentation] アストロサイトからみた脳の機能変調-脳卒中を中心に (2017)
  • Author(s): 小泉修一
  • Organizer: 次世代脳プロジェクト冬のシンポジウム2017
• [Presentation] Gliopsychiatry研究；抗うつ薬の作用標的としてのグリア細胞 (2016)
  • Author(s): 小泉修一
  • Organizer: 第59回日本神経化学会大会・第38回日本生物学的精神医学会
  • Place of Presentation: 福岡国際会議場（福岡県・福岡市）
  • Year and Date: 2016-09-10
• [Presentation] 大脳皮質体性感覚野アストロサイトと慢性疼痛 (2016)
  • Author(s): 小泉修一
  • Organizer: 第24回日本腰痛学会
  • Place of Presentation: 富士屋ホテル（山梨県・甲府市）
  • Year and Date: 2016-09-03
• [Presentation] アストロサイトGqPCR過剰発現による神経過興奮 (2016)
  • Author(s): 繁冨英治
  • Organizer: 第46回日本神経精神薬理学会年会
  • Place of Presentation: ソウル（韓国）
  • Year and Date: 2016-07-03
• [Presentation] グリア細胞によるシナプス機能及び構造の制御 (2016)
  • Author(s): 小泉修一
  • Organizer: 浜松医大開学記念式典特別講演
  • Place of Presentation: 浜松医科大学（静岡県・浜松市）
  • Year and Date: 2016-06-07
  • Invited
• [Remarks] 薬理学HP
  • URL: http://www.med.yamanashi.ac.jp/clinical_basic/pharmaco/