• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Regulation of brain functions by phagocytic astrocytes

Research Project

Project/Area Number 16H04669
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurochemistry/Neuropharmacology
Research InstitutionUniversity of Yamanashi

Principal Investigator

KOIZUMI Schuichi  山梨大学, 大学院総合研究部, 教授 (10280752)

Co-Investigator(Kenkyū-buntansha) 繁冨 英治  山梨大学, 大学院総合研究部, 助教 (00631061)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2018: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Keywordsアストロサイト / 貪食 / シナプス再編 / 神経ネットワーク再編 / 脳卒中 / ミクログリア / ABCA1 / 神経機能 / リモデリング / 神経科学 / 脳・神経 / 脳神経疾患 / 薬理学
Outline of Final Research Achievements

The importance of glial cells in neural network remodeling has been pointed out. Astrocytes, a type of glial cells, acquire phagocytosis after stroke, prune synapses, and play a central role in neural network remodeling, according to a new study. Early after stroke, microglia accumulate in the center of the infarct layer (core region) and remove dead cells and their fragments from the brain by phagocytosis. On the other hand, in the periphery of the infarct layer (penumbra region), astrocytes were activated and acquired phagocytosis, reaping weakened synapses by phagocytosis and building new neural networks. We also found that astrocytes were altered to be phagocytic by increasing the expression of ABCA1.

Academic Significance and Societal Importance of the Research Achievements

脳機能変化は、シナプス再編により神経ネットワークが繋ぎ変わることで実現する。これまでシナプス再編は、神経細胞の自律性により制御されると考えられてきたが、グリア細胞の役割を明らかとした。脳卒中直後は主にミクログリアが、脳卒中後期には特に梗塞層の周辺部位でアストロサイトが貪食によりシナプスを刈込み、神経ネットワーク再編を行うことを明らかにした。また、アストロサイトの貪食を規定する分子として、ABCA1を見いだした。これらは、アストロサイトを上手に制御することで、神経ネットワーク再編、ひいては脳機能を制御する新しい戦略に繋がる重要な知見である。

Report

(4 results)
  • 2019 Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (79 results)

All 2019 2018 2017 2016 Other

All Journal Article (24 results) (of which Int'l Joint Research: 16 results,  Peer Reviewed: 24 results,  Open Access: 22 results,  Acknowledgement Compliant: 4 results) Presentation (54 results) (of which Int'l Joint Research: 19 results,  Invited: 22 results) Remarks (1 results)

  • [Journal Article] Evaluation of M1-microglial activation by neurotoxic metals using optimized organotypic cerebral slice cultures2019

    • Author(s)
      Hoshi T, Toyama T, Shinozaki Y, Koizumi S, Lee JY, Naganuma A, Hwang GW.
    • Journal Title

      The Journal of Toxicological Sciences

      Volume: 44 Issue: 7 Pages: 471-479

    • DOI

      10.2131/jts.44.471

    • NAID

      130007674444

    • ISSN
      0388-1350, 1880-3989
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Microglial ROCK is essential for chronic methylmercury-induced neurodegeneration.2019

    • Author(s)
      Shinozaki Y, Danjo Y, Koizumi S
    • Journal Title

      J Neurochemistry

      Volume: 151 Issue: 1 Pages: 64-78

    • DOI

      10.1111/jnc.14817

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intermittent restraint stress induces circadian misalignment in the mouse bladder, leading to nocturia.2019

    • Author(s)
      Ihara T, Nakamura Y, Mitsui T, Tsuchiya S, Kanda M, Kira S, Nakagomi H, Sawada N, Kamiyama M, Shigetomi E, Shinozaki Y, Yoshiyama M, Nakao A, Koizumi S, Takeda M.
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 10069-10069

    • DOI

      10.1038/s41598-019-46517-w

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Snake venom rhodocytin induces plasma extravasation via toxin-mediated interactions between platelets and mast cells2019

    • Author(s)
      Y. Nakamura, T. Sasaki, C. Mochizuki, K. Ishimaru, S. Koizumi, H. Shinmori, K. Suzuki-Inoue, A. Nakao
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 15958-15958

    • DOI

      10.1038/s41598-019-52449-2

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] New roles of reactive astrocytes in the brain; an organizer of cerebral ischemia.2018

    • Author(s)
      Koizumi, S., Hirayama, Y., Morizawa, YM
    • Journal Title

      Neurochem Int

      Volume: in press Pages: 107-114

    • DOI

      10.1016/j.neuint.2018.01.007

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Anti-depressant fluoxetine reveals its therapeutic effects via astrocytes.2018

    • Author(s)
      M. Kinoshita, Y. Hirayama, K. Fujishita, K Shibata, Y. Shinozaki, E. Shigetomi, A. Takeda, HP Ngoc Le, H. Hayashi, M. Hiasa, Y. Moriyama, K. Ikenaka, KF Tanaka, S. Koizumi.
    • Journal Title

      EBioMedicine

      Volume: 32 Pages: 72-83

    • DOI

      10.1016/j.ebiom.2018.05.036

    • NAID

      130007901327

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The oscillation of intracellular Ca2+ influx associated with the circadian expression of Piezo1 and TRPV4 in the bladder urothelium2018

    • Author(s)
      Ihara Tatsuya、Mitsui Takahiko、Nakamura Yuki、Kanda Mie、Tsuchiya Sachiko、Kira Satoru、Nakagomi Hiroshi、Sawada Norifumi、Kamiyama Manabu、Hirayama Yuri、Shigetomi Eiji、Shinozaki Youichi、Yoshiyama Mitsuharu、Nakao Atsuhito、Takeda Masayuki、Koizumi Schuichi
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 5699-5699

    • DOI

      10.1038/s41598-018-23115-w

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The time-dependent variation of ATP release in mouse primary cultured urothelial cells is regulated by the Clock gene.2018

    • Author(s)
      Ihara T, Mitsui T, Nakamura Y, Kanda M, Tsuchiya S, Kira S, Nakagomi H, Sawada N, Kamiyama M, Hirayama Y, Shigetomi E, Shinozaki Y, Yoshiyama M, Nakao A, Takeda M Koizumi S
    • Journal Title

      Neurourology and urodynamics

      Volume: 37 Issue: 8 Pages: 2535-2543

    • DOI

      10.1002/nau.23793

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Neuroprotective effects of microglial P2Y1 receptors against ischemic neuronal injury.2018

    • Author(s)
      Fukumoto, Y., Tanaka, KF., Parajuli, B., Shibata, K., Yoshioka, H., Kanemaru, K., Gachet, C., Ikenaka, K., Koizumi, S. Kinouchi, H.
    • Journal Title

      J Cereb Blood FloTakew Metab,

      Volume: - Issue: 11 Pages: 2144-2156

    • DOI

      10.1177/0271678x18805317

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Microglia mediate non-cell-autonomous cell death of retinal ganglion cells.2018

    • Author(s)
      Takeda A, Shinozaki Y, Kashiwagi K, Ohno N, Eto K, Wake H, Nabekura J, Koizumi S.
    • Journal Title

      Glia

      Volume: 66 Issue: 11 Pages: 2366-2384

    • DOI

      10.1002/glia.23475

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Involvement of VNUT-exocytosis in transient receptor potential vanilloid 4-dependent ATP release from gastrointestinal epithelium.2018

    • Author(s)
      Mihara, H., Uchida, K., Koizumi, S., Moriyama, Y
    • Journal Title

      PloS One

      Volume: 13(10) Issue: 10 Pages: e0206276-e0206276

    • DOI

      10.1371/journal.pone.0206276

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of Purinergic Receptor P2Y1 in Spatiotemporal Ca2+ Dynamics in Astrocytes.2018

    • Author(s)
      Shigetomi E, Hirayama YJ, Ikenaka K, Tanaka KF, Koizumi S.
    • Journal Title

      The Journal of Neuroscience

      Volume: 38 Issue: 6 Pages: 1053-1067

    • DOI

      10.1523/jneurosci.2625-17.2017

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Aberrant astrocyte Ca2+ signals “AxCa signals” exacerbate pathological alterations in an Alexander disease model2018

    • Author(s)
      Saito Kozo、Shigetomi Eiji、Yasuda Rei、Sato Ryuichi、Nakano Masakazu、Tashiro Kei、Tanaka Kenji F.、Ikenaka Kazuhiro、Mikoshiba Katsuhiko、Mizuta Ikuko、Yoshida Tomokatsu、Nakagawa Masanori、Mizuno Toshiki、Koizumi Schuichi
    • Journal Title

      Glia

      Volume: 66 Issue: 5 Pages: 1053-1067

    • DOI

      10.1002/glia.23300

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Astrocyte-mediated synapse remodeling in the pathological brain2017

    • Author(s)
      Kim Sun Kwang、Nabekura Junichi、Koizumi Schuichi
    • Journal Title

      Glia

      Volume: 65 Issue: 11 Pages: 1719-1727

    • DOI

      10.1002/glia.23169

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Transformation of Astrocytes to a Neuroprotective Phenotype by Microglia via P2Y1 Receptor Downregulation.2017

    • Author(s)
      Shinozaki Y, Shibata K, Yoshida K, Shigetomi E, Gachet C, Ikenaka K, Tanaka KF, Koizumi S.
    • Journal Title

      Cell Rep

      Volume: 19 Issue: 6 Pages: 1151-1164

    • DOI

      10.1016/j.celrep.2017.04.047

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway2017

    • Author(s)
      Morizawa Yosuke M.、Hirayama Yuri、Ohno Nobuhiko、Shibata Shinsuke、Shigetomi Eiji、Sui Yang、Nabekura Junichi、Sato Koichi、Okajima Fumikazu、Takebayashi Hirohide、Okano Hideyuki、Koizumi Schuichi
    • Journal Title

      Nature Communications

      Volume: 8 Issue: 1 Pages: 28-28

    • DOI

      10.1038/s41467-017-00037-1

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Purinergic dysregulation causes hypertensive glaucoma-like optic neuropathy.2017

    • Author(s)
      Shinozaki Y, Kashiwagi K, Namekata K, Takeda A, Ohno N, Robaye B, Harada T, Iwata T, *Koizumi S
    • Journal Title

      JCI Insight

      Volume: 2 Issue: 19

    • DOI

      10.1172/jci.insight.93456

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hypoxia-independent mechanisms of HIF-1α expression in astrocytes after ischemic preconditioning.2017

    • Author(s)
      Hirayama, Y., Koizumi, S.
    • Journal Title

      Glia.

      Volume: 65 Issue: 3 Pages: 523-530

    • DOI

      10.1002/glia.23109

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Carbenoxolone inhibits TRPV4 channel-initiated oxidative urothelial injury and ameliorates cyclophosphamide-induced bladder dysfunction2017

    • Author(s)
      Zhang X,Gao S,Tanaka M,Zhanq Z,Huanq Y,Mitsui T,Kamiyama M,Koizumi S,Fan J,Takeda M,Yao J
    • Journal Title

      J Cell Mol Med

      Volume: 2017 Issue: 9 Pages: 346-346

    • DOI

      10.1111/jcmm.13100

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Cortical astrocytes rewire somatosensory cortical circuits for peripheral neuropathic pain.2016

    • Author(s)
      Kim SK, Hayashi H, Ishikawa T, Shibata K, Shigetomi E, Shinozaki Y, Inada H, Roh SE, Kim SJ, Lee G, Bae H, Moorhouse AJ, Mikoshiba K, Fukazawa Y, Koizumi S, Nabekura J.
    • Journal Title

      J Clin Invest

      Volume: 126(5) Issue: 5 Pages: 1983-1997

    • DOI

      10.1172/jci82859

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Microglia contact induces synapse formation in developing somatosensory cortex.2016

    • Author(s)
      Miyamoto A, Wake H, Ishikawa AW, Eto K, Shibata K, Murakoshi H, Koizumi S, Moorhouse AJ, Yoshimura Y, Nabekura J
    • Journal Title

      Nature Communications

      Volume: 7 Issue: 1 Pages: 1-12

    • DOI

      10.1038/ncomms12540

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Clock mutant mouse is a novel experimental model for nocturia and nocturnal polyuria.2016

    • Author(s)
      Ihara, T., Mitsui, T., Nakamura, Y., Kira, S., Miyamoto, T., Nakagomi, H., Sawada, N., Hirayama, Y., Shibata, K., Shigetomi, E., Shinozaki, Y., Yoshiyama, M., Nakao, A., *Takeda, M. *Koizumi, S.
    • Journal Title

      Neurourology and Urodynamics

      Volume: 36 Issue: 4 Pages: 1034-1038

    • DOI

      10.1002/nau.23062

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Urothelial ATP exocytosis: regulation of bladder compliance in the urine storage phase2016

    • Author(s)
      Nakagomi H,Yoshiyama M,Mochizuki T,Miyamoto T,Komatsu R,Imura Y,Morizawa Y,Hiasa M,Kira S,Fujishita K,Shibata K,Shigetomi E,Shinozaki Y,Takeda M,Koizumi S
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 29761-29761

    • DOI

      10.1038/srep29761

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] An effective therapeutic approach for oxaliplatin-induced peripheral neuropathy using combination therapy with Goshajinkigan and Bushi.2016

    • Author(s)
      Mizuno, K., Shibata, K., Komatsu, R., Omiya, Y., Kase, Y. and *Koizumi, S.
    • Journal Title

      Cancer Biol Ther

      Volume: 17 Pages: 1206-1212

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] グリアからみた発現メカニズム~生化学的アプローチ~2019

    • Author(s)
      小泉修一
    • Organizer
      Glutamate Conference
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Reappearance of astrocytic mGluR5 assembles cortical networks in induction of neuropathic pain.2019

    • Author(s)
      Danjo, Y., Hirayama, YJ, Shigetomi, E., Shibata, K., Takanashi, K., Shinozaki, Y., Kim, SK, Nabekura, J., Koizumi, S.
    • Organizer
      第92回日本薬理学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Glial purinergic signals as a target for antidepressants.2019

    • Author(s)
      Koizumi, S.
    • Organizer
      第92回日本薬理学会年会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Monitoring bidirectional information processing between neurons and astrocyte.2019

    • Author(s)
      Shigetomi, E., Koizumi, S
    • Organizer
      第92回日本薬理学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Synapse remodeling by astrocytes2019

    • Author(s)
      Koizumi, S
    • Organizer
      ケベック大学カンファレンス
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Role of calcium signals in reactive astrocytes.2019

    • Author(s)
      Shigetomi, E
    • Organizer
      ケベック大学カンファレンス
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] グリアによる一次体性感覚野のシナプス再編2019

    • Author(s)
      小泉修一
    • Organizer
      第7回神経と免疫を語る会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Bidirectional regulation of synapse remodeling by reactive astrocytes2019

    • Author(s)
      Koizumi, S
    • Organizer
      FAOPS2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Visualization of spatiotemporal interaction of neurons and astrocytes.2019

    • Author(s)
      Shigetomi, E., Hirayama, JY., Ikenaka, K., Tanaka, FK., Bito, H., Koizumi, S.
    • Organizer
      FAOPS2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] アストロサイト性シナプス再編2018

    • Author(s)
      小泉修一、檀上洋右、鍋倉淳一
    • Organizer
      第2回感覚免疫学研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Ischemic tolerance and glial purinergic signaling.2018

    • Author(s)
      Koizumi, S
    • Organizer
      Purines2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Astrocyte-synapse interaction in health and diseases.2018

    • Author(s)
      Koizumi, S
    • Organizer
      WCP2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Dynamic interaction of neurons and astrocytes revealed dual color Ca2+ imaging.2018

    • Author(s)
      Shigetomi, E., Hirayama, Y., Ikenaka, K., Tanaka, FK, Bito, H., Koizumi, S.
    • Organizer
      WCP2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Remodeling the brain after stroke by astrocytic phagocytosis.2018

    • Author(s)
      Morizawa, Y., Koizumi, S
    • Organizer
      WCP2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] An essential role of astrocytic mGluR5 in the somatosensory cortex in regulation of synaptogenesis and neuropathic pain.2018

    • Author(s)
      Danjo, Y., Hirayama, Y., Shigetomi, E., Shibata, K., Takanashi, K., Shinozaki, Y., Kim, SK, Nabekura, J., Koizumi, S
    • Organizer
      WCP2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] グリア細胞による脳リモデリング2018

    • Author(s)
      小泉修一
    • Organizer
      第48回新潟神経学夏期セミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Astrocyte-dependent brain remodeling.2018

    • Author(s)
      Koizumi, S
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Role of microglia in astrogliopahty: a study of Alexander disease model2018

    • Author(s)
      Shigetomi, E., Kobayashi, K., Saito, K., Koizumi, S.
    • Organizer
      第61回日本神経化学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Astrocyte-mediated network remodeling.2018

    • Author(s)
      Koizumi S
    • Organizer
      第61回日本神経化学会大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Reappearance of astricytic mGluR5 in the primary somatosensory cortex is a cause of neuropathic pain - reassembles of cortical networks2018

    • Author(s)
      Danjo, Y., Hirayama, Y., Shigetomi, E., Shibata, K., Takanashi, K., Shinozaki, Y., Kim, SK., Nabekura, J., Koizumi, S.
    • Organizer
      第61回日本神経化学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] A new role of astrocytes in regulation of brain function by ABCA1.2018

    • Author(s)
      Koizumi S., Morizawa, Y.
    • Organizer
      第91回日本生化学会大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Bidirectional synapse remodeling by reactive astrocytes.2018

    • Author(s)
      Koizumi S
    • Organizer
      YoungGlia glial heterogeneity meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 脳虚血耐性におけるアストロサイトP2X7受容体活性化メカニズムの解析2018

    • Author(s)
      平山友里、石井伊都子、安西尚彦、小泉修一
    • Organizer
      第139回日本薬理学会関東部会
    • Related Report
      2018 Annual Research Report
  • [Presentation] VNUT-mediated microglia ATP excytosis contributes to Neuroprotection in the ischemic brain.2018

    • Author(s)
      Ngoc, Le HP., Hirayama, Y., Tanaka, FK., Koizumi, S
    • Organizer
      2018 Cold Spring Harbor Asia Conference.
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Reactive astrocyte-mediated synapse remodeling.2018

    • Author(s)
      Koizumi, S.
    • Organizer
      2018 Cold Spring Harbor Asia Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A network remodeling by reactive astrocytes.2018

    • Author(s)
      Koizumi, S.
    • Organizer
      The Glia Section of The Korean Society for Brain and Neural Sciences.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] グリア細胞による神経障害性疼痛アロディニア誘導メカニズム2018

    • Author(s)
      小泉修一
    • Organizer
      第1回Hz-S フォーラム
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A new role of reactive astrocytes; a network remodeling.2018

    • Author(s)
      Koizumi, S
    • Organizer
      第1回山梨大学先端脳科学特別教育プログラム国際シンポジウム
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 貪食性アストロサイトによる神経回路リモデリング2018

    • Author(s)
      小泉修一、森澤陽介、平山友里
    • Organizer
      第138回日本薬理学会関東部会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 一次体性感覚野のATP増加がアストロサイト性シナプス再編及び機械的アロディニアを引き起こす2017

    • Author(s)
      柴田圭輔、久保田啓太、石川達也、篠崎陽一、繁冨英治、御子柴克彦、鍋倉淳一、小泉修一
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎ブリックホール(長崎県・長崎市)
    • Year and Date
      2017-03-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] Cortical synaptic remodeling by astrocytes2017

    • Author(s)
      Koizumi, S
    • Organizer
      The 3rd Symposium of NeuroScience Network in Kobe.
    • Place of Presentation
      (兵庫県・神戸市)
    • Year and Date
      2017-02-17
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] アストロサイトによる体性感覚野神経回路の組み替えと慢性疼痛2017

    • Author(s)
      小泉修一
    • Organizer
      北陸大学グリアセミナー
    • Place of Presentation
      北陸大学(石川県・金沢市)
    • Year and Date
      2017-02-15
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Glia-Mediated Eplileptogenicity.2017

    • Author(s)
      Koizumi, S
    • Organizer
      The 5th congress of AsCNP.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ミクログリアは脳傷害後の神経保護的アストロサイトを誘導する2017

    • Author(s)
      篠崎陽一、柴田圭輔、吉田慶太郎、繁冨英治、田中謙二、小泉修一
    • Organizer
      第136回日本薬理学会関東部会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Cortical astrocytes rewire somatosensory cortical circuits for peripheral neuropathic pain2017

    • Author(s)
      Koizumi, S., Kim, S, K., Nabekura, J
    • Organizer
      ⅩⅢ EUROPEAN Meeting on Glial Cells in Health and Disease
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] アストロサイトCa2+シグナルの時空間ダイナミクスの多様性と脳機能制御2017

    • Author(s)
      繁冨英治
    • Organizer
      日本大学歯学部セミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] When do astrocytes listen to ATP derived from neurons?2017

    • Author(s)
      Shigetomi, E., Hirayama, Y., Sano, F., Koizumi, S.
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Astrocytes mediate synaptic rewiring.2017

    • Author(s)
      Koizumi, S., Shibata, K., Kim, S, K., Nabekura, J
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] グリア性虚血耐性とその分子メカニズム2017

    • Author(s)
      小泉修一、平山友里
    • Organizer
      第18回日本分子脳神経外科学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Glia-mediated ischemic tolerance.2017

    • Author(s)
      Hirayama, Y., Koizumi, S
    • Organizer
      第60回日本神経化学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Microglia-induced astrocytic P2Y1 receptor down-regulation causes astrocyte scar formation2017

    • Author(s)
      Shinozaki, Y., Shibata, K., Shigetomi, E., Yoshida, K., Ikenaka, K., Tanaka, F, K., Koizumi, S
    • Organizer
      第60回日本神経化学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Phagocytic astrocytes after brain ischemia2017

    • Author(s)
      Morizawa, Y., Koizumi, S.
    • Organizer
      第60回日本神経化学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Epileptogenic astrocytes.2017

    • Author(s)
      Koizumi, S
    • Organizer
      第60回日本神経化学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] グリア細胞による神経回路リモデリング2017

    • Author(s)
      小泉修一
    • Organizer
      第19回応用薬理シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ミクログリアはアストロサイトのP2Y1受容体発現低下を介して神経保護機能を誘導する2017

    • Author(s)
      篠崎陽一、柴田圭輔、吉田慶太郎、繁冨英治、田中謙二、小泉修一
    • Organizer
      第39回日本生物学的精神医学会・第47回日本神経精神薬理学会合同年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] アストロサイトによる神経ネットワーク再構築と疾患2017

    • Author(s)
      小泉修一
    • Organizer
      千里ライフサイエンスセミナーL3
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Rewiring of Neuronal Networks by Astrocytic Ca2+ in the Somatosensory Cortex.2017

    • Author(s)
      Koizumi, S
    • Organizer
      20th International Symposium on Calcium Binding Proteins and Calcium Function I Health and Disease.(CaBP20)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] アストロサイト微細突起Ca2+シグナルにおけるP2Y1受容体の役割2017

    • Author(s)
      繁冨英治、平山幸歩、小泉修一
    • Organizer
      第137回日本薬理学会関東部会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Mechanism underlying hypoxia-independent upregulation of adtrocytic HIF-α after ischemic preconditioning.2017

    • Author(s)
      Hirayama, Y., H. P. N. LE., Koizumi, S.
    • Organizer
      Neuroscience2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] アストロサイトからみた脳の機能変調-脳卒中を中心に2017

    • Author(s)
      小泉修一
    • Organizer
      次世代脳プロジェクト冬のシンポジウム2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] Gliopsychiatry研究;抗うつ薬の作用標的としてのグリア細胞2016

    • Author(s)
      小泉修一
    • Organizer
      第59回日本神経化学会大会・第38回日本生物学的精神医学会
    • Place of Presentation
      福岡国際会議場(福岡県・福岡市)
    • Year and Date
      2016-09-10
    • Related Report
      2016 Annual Research Report
  • [Presentation] 大脳皮質体性感覚野アストロサイトと慢性疼痛2016

    • Author(s)
      小泉修一
    • Organizer
      第24回日本腰痛学会
    • Place of Presentation
      富士屋ホテル(山梨県・甲府市)
    • Year and Date
      2016-09-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] アストロサイトGqPCR過剰発現による神経過興奮2016

    • Author(s)
      繁冨英治
    • Organizer
      第46回日本神経精神薬理学会年会
    • Place of Presentation
      ソウル(韓国)
    • Year and Date
      2016-07-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] グリア細胞によるシナプス機能及び構造の制御2016

    • Author(s)
      小泉修一
    • Organizer
      浜松医大開学記念式典特別講演
    • Place of Presentation
      浜松医科大学(静岡県・浜松市)
    • Year and Date
      2016-06-07
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Remarks] 薬理学HP

    • URL

      http://www.med.yamanashi.ac.jp/clinical_basic/pharmaco/

    • Related Report
      2016 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2021-02-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi