Molecular mechanism of neuronal network regeneration in the adult mouse brain
| Project/Area Number |
16H04672
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | National Center of Neurology and Psychiatry (2018)
Osaka University (2016-2017) |
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Principal Investigator |
Muramatsu Rieko 国立研究開発法人国立精神・神経医療研究センター, 神経研究所 神経薬理研究部, 部長 (90536880)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2018: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2016: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Keywords | 多発性硬化症 / 髄鞘 / 神経回路 / 脱髄 / 血液脳関門 / 白質 / 細胞増殖 / 脊髄 / オリゴデンドロサイト / ミエリン |
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| Outline of Final Research Achievements |
Central nervous system (CNS) inflammation causes disruption of neuronal network, resulting in cause severe neurological dysfunction. Although it has been believed that neuronal network in the CNS can not regenerate in adult mammalians, recent studies observe the spontaneous regeneration of the neuronal network in the CNS, indicating that neural cells in the adult CNS still has the potential to regenerate against injury. Due to the understand the mechanism of spontaneous regeneration, we focused on the vascular disruption, which is a promising feature around the lesion, and found that the molecules which drive CNS regeneration contain the circulation. We revealed that circulating factors leaks into the CNS in the response to CNS injury, resulting in promotes CNS remyelination. These results give the circulating molecules a role for regulation of CNS regeneration.
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| Academic Significance and Societal Importance of the Research Achievements |
脳の神経回路の修復研究は、脳の内部の細胞や分子の働きを理解する形で知見が積み上げられている。一方、病態では、病巣周囲で血管のバリア機能が破綻し、血液が脳に流入しやすい状態になっている。血液には、種々の生理活性物質が含まれているが、血液の脳内への流入が神経回路の修復にいかなる影響を与えるかは不明であった。本研究は、血液を介して、脳以外の臓器が脳神経回路の修復を制御するという新しい知見を示すものであり、神経回路の修復研究に新しい方向性を示すものである。また、得られた分子メカニズムは、神経回路の修復により症状改善が見込める種々の疾患の治療薬のシーズとなるポテンシャルもあり、臨床的にも意義深い。
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Peripherally derived FGF21 promotes remyelination in the central nervous system.2017
Author(s)
Kuroda M, Muramatsu R, Maedera N, Koyama Y, Hamaguchi M, Fujimura H, Yoshida M, Konishi M, Itoh N, Mochizuki H, Yamashita T.
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Journal Title
J Clin Invest.
Volume: 127
Issue: 9
Pages: 3496-3509
DOI
Related Report
Peer Reviewed / Open Access
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