| Budget Amount *help |
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2019: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2018: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
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| Outline of Final Research Achievements |
Leukotriene B4 generated within the brain in response to intracerebral hemorrhage (ICH) was found to determine the prognosis by promoting leukocyte infiltration and participating in inflammatory responses and axon tract damage in the brain. In addition, stimulation of ligand-dependent transcription factors such as Nurr1 and aryl hydrocarbon receptor was shown to alleviate pathological events in ICH by inhibiting leukocyte infiltration and/or microglia/macrophage recruitment. Moreover, a novel experimental system using brain slice cultures was developed to give rudimentary findings concerning the dynamics of neutrophil phenotypes associated with ICH.
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