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Identification of a causal gene for QTL affecting overweight and resistance to obesity discovered from a gene pool of wild mice

Research Project

Project/Area Number 16H04680
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory animal science
Research InstitutionNagoya University

Principal Investigator

Ishikawa Akira  名古屋大学, 生命農学研究科, 准教授 (20211724)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2019: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2018: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Keywordsマウス / QTL / 肥満 / 体重 / QTL
Outline of Final Research Achievements

Overweight and obesity in humans are main risk factors for lifestyle diseases which are controlled by multiple genetic loci (QTLs: quantitative trait loci) and environment. To identify causal genes for the QTLs remains challenging. In this study, by using new analytical approaches, I first identified the Ly75 (lymphocyte antigen 75) gene for an immune system as a causal gene for a QTL affecting resistance to obesity that was previously discovered from a gene pool of wild mice.

Academic Significance and Societal Importance of the Research Achievements

本研究成果は、肥満に関わるQTLの責任遺伝子を同定した数少ない成功例の一つと位置付けることができる。Ly75遺伝子の脂質代謝に関わる役割は全く報告されていないので、本研究成果は、肥満生物学に新しい知見を提供するものと期待できる。また、本研究成果は、ヒトでは、万病の元である肥満を克服するためのゲノム医療への応用が期待できる。さらに、家畜では、家畜の健康改善と畜産物の生産性の向上のためのゲノム育種への応用が期待できる。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (13 results)

All 2019 2018 2017 2016

All Journal Article (5 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (8 results) (of which Int'l Joint Research: 2 results,  Invited: 3 results)

  • [Journal Article] 野生マウスの遺伝子プールから発掘した新奇肥満抑制遺伝子2019

    • Author(s)
      石川 明
    • Journal Title

      Medical Science Digest

      Volume: 45 Pages: 285-286

    • Related Report
      2019 Annual Research Report
  • [Journal Article] マウスの肥満を抑制する新奇遺伝子の同定2019

    • Author(s)
      石川 明
    • Journal Title

      アグリバイオ

      Volume: 3 Pages: 1176-1178

    • NAID

      40022107513

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Genetic identification of Ly75 as a novel quantitative trait gene for resistance to obesity in mice2018

    • Author(s)
      Makino Keita、Ishikawa Akira
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 17658-17658

    • DOI

      10.1038/s41598-018-36073-0

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A strategy for identifying quantitative trait genes using gene expression analysis and causal analysis2017

    • Author(s)
      Ishikawa, A.
    • Journal Title

      Genes

      Volume: 8 Issue: 12 Pages: 347-347

    • DOI

      10.3390/genes8120347

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification of a putative quantitative trait gene for resistance to obesity in mice using transcriptome analysis and causal inference tests2017

    • Author(s)
      Ishikawa, A.
    • Journal Title

      PLoS ONE

      Volume: 12 Issue: 1 Pages: e0170652-e0170652

    • DOI

      10.1371/journal.pone.0170652

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 野生マウスの肥満抵抗性に関わる新規量的形質遺伝子の同定2018

    • Author(s)
      石川明、牧野圭汰
    • Organizer
      第65回日本実験動物学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] マウス白色脂肪組織重量に関与する量的形質遺伝子の同定2018

    • Author(s)
      牧野圭汰、石川明
    • Organizer
      日本畜産学会第124回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 量的相補性検定によるマウスの腎臓重量に関わる量的形質遺伝子(QTG)の同定2017

    • Author(s)
      牧野圭汰、石川明
    • Organizer
      第64回日本実験動物学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Toward the identification of causal genes for quantitative trait variation: lessons from QTL studies on growth and obesity in mice2017

    • Author(s)
      Ishikawa, A.
    • Organizer
      The 2017 KALAS International Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Identification of a putative quantitative trait gene for resistance to obesity in mice2017

    • Author(s)
      Ishikawa, A.
    • Organizer
      EMBL Conference Mammalian Genetics and Genomics: From Molecular Mechanisms to Translational Applications
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] マウスからのニワトリへのトランスレーショナルリサーチ ~ニワトリ量的形質遺伝子の同定を目指して~2016

    • Author(s)
      石川 明
    • Organizer
      第15回JAB(Japanese Avian Bioresource Project Research Center)特別セミナー
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] マウスの成長形質関連遺伝子の探索2016

    • Author(s)
      石川 明
    • Organizer
      日本動物遺伝育種学会第17回大会シンポジウム「ポストQTL時代のQTG・QTN研究の現状と展望」
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] マウス白色脂肪組織重量および腎臓重量に関わるQTLの責任遺伝子の探索2016

    • Author(s)
      牧野圭汰、石川 明
    • Organizer
      日本動物遺伝育種学会第17回大会
    • Related Report
      2016 Annual Research Report

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Published: 2016-04-21   Modified: 2021-02-19  

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