Biological role of CD280 in cancer metastasis-initiating cell
| Project/Area Number |
16H04697
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2018: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Keywords | 癌転移 / スキルス胃癌 / 腹膜転移 / 分子標的 / 癌治療 / シングルセル解析 / 間質 / 細胞表面マーカー / 幹細胞性 / 診断マーカー / 分子標的治療 / 癌転移開始細胞 / バイオマーカー / 治療 / 胃癌 / 前立腺癌 / 結腸癌 / 膵臓癌 / 同所性移植 |
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| Outline of Final Research Achievements |
The concept of metastasis-initiating cells (MICs) has been proposed. MICs originate in the primary tumors and are considered special cells to promote cancer metastasis. However, MICs have not been investigated in detail. We successfully isolated MICs from primary cancer tissues of a scirrhous gastric cancer patient, and then knocked out CD280 expression via genome editing methods. The CD280-deficient MICs showed the decreased proliferation, colony formation, and invasion activity compared with CD280 wild-type MICs. CD280 is a novel target to inhibit cancer metastasis.
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| Academic Significance and Societal Importance of the Research Achievements |
癌転移研究は大変遅れている。その理由に、癌転移の良いモデルがない現状がある。我々は、癌転移でメインプレーヤーとなる癌転移開始細胞（MIC）を、スキルス胃癌患者から成功裡に単離した。その解析から、CD280がMICの機能維持に重要で、癌転移抑制に有用な新規標的であることが分かった。癌の死因の大半は癌転移による。故に癌患者の予後において、癌転移抑止医療が大切になる。本成果は、癌転移抑止医療の実現に繋がる社会的意義を有する。
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Sodium chloride promotes tissue inflammation via osmotic stimuli in sub-total-nephrectomized mice.2017
Author(s)
Sakata F., Ito Y., Mizuno M, Sawai A, Suzuki Y, Tomita T, Tawada M, Tanaka A, Hirayama A, Sagara A, Wada T, Maruyama S, Soga T, Matsuo S, Imai E, Takei Y.
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Journal Title
Lab Invest
Volume: 97(4)
Issue: 4
Pages: 432-446
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Apoptosis inhibitor of macrophage ameliorates fungus-induced peritoneal injury model in mice2017
Author(s)
Tomita T, Arai S, Kitada K, Mizuno M, Suzuki Y, Sakata F, Nakano D, Hiramoto E, Takei Y, Maruyama S, Nishiyama A, Matsuo S, Miyazaki T, Ito Y.
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Journal Title
Sci Rep
Volume: 7
Issue: 1
Pages: 6450-6450
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Vascular endothelial cell injury is an important factor in the development of encapsulating peritoneal sclerosis in long-term peritoneal dialysis patients.2016
Author(s)
Tawada M, Ito Y, Hamada C, Honda K, Mizuno M, Suzuki Y, Sakata F, Terabayashi T, Matsukawa Y, Maruyama S, Imai E, Matsuo S, Takei Y.
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Journal Title
PLoS One
Volume: 11
Issue: 4
Pages: e0154644-e0154644
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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