| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2018: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Outline of Final Research Achievements |
Employing a functional genomic screening with DECIPHER barcode short hairpin RNA libraries, we identified a gene X, which exhibited synthetic lethality with inhibitors for the poly(ADP-ribose) polymerase called tankyrase. While tankyrase inhibitors downregulate beta-catenin signaling and block proliferation of APC-mutated colorectal cancer cells, we found that depletion of gene X enhances the anticancer effects of tankyrase inhibitors in a beta-catenin-independent manner.
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