| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2018: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Outline of Final Research Achievements |
Metabolic stress responses of cancer cells play an important role in cell survival and growth under various tumor-associated conditions. In this study, we focused on the diversity of activation mechanisms of integrated stress response (ISR) pathway among metabolic stress responses. By screening a kinase inhibitor library, we succeeded in identifying compounds that modulate oncogenic signals and control the ISR. Using these compounds, we further promoted research for establishing a novel therapeutic strategy that induces synthetic lethality through controlling the ISR.
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