| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2018: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2016: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
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| Outline of Final Research Achievements |
he intracellular Ca2+ concentration is tissue-specifically regulated by SERCA, the Ca2+ pump located at the sarco/endoplasmic reticulum membrane. The ultimate goal of this study is to understand the mechanism of the regulation of intracellular Ca2+ concentration mediated by SERCA based on the atomic structures. We have expanded our research target from skeletal muscle-specific SERCA1a to other isoforms which are biologically and medically important and closely related to diseases, such as SERCA2a, SERCA2b and SERCA3. Base on the crystal structures of these isoforms in the various states, we aimed to understand the tissue-specific intracellular Ca2+ control mechanism.
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