| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2018: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2017: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
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| Outline of Final Research Achievements |
In addition to the nucleic acid molecule tRNA, which is an adapter molecule in genetic decoding for sense codons, for decoding mRNA by ribosomes in protein synthesis, a set of tRNA mimicry proteins are known, such as for the decoding of translation termination codon and for the rescue of ribosomes stalled on aberrant mRNA. In this study, by comparative analysis of both eukaryotic and bacterial tRNA mimicry proteins, we have demonstrated the novel functionality of a eukaryote specific GTP binding protein, Ski7. We also succeeded in finding novel ribosome rescue mechanism including the poly peptide-chain release factors (eRF1/eRF3) that has not been reported so far in eukaryotes.
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