| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2019: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
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| Outline of Final Research Achievements |
To understand intracellular dynamics of metal ions (copper ions, in particular), I have focused upon Cu/Zn-superoxide dismutase (SOD1), which is one of the most important copper proteins, as well as the copper chaperone protein CCS that supplies copper ions to SOD1. This study has suggested a new mechanistic action of CCS on SOD1 upon the copper supply and also newly identified a protein interacting with CCS. Furthermore, the breakdown of a copper supplying step to SOD1 was evaluated as a possible pathological change occurring in a neurodegenerative disease, amyotrophic lateral sclerosis (ALS). Misfolded SOD1 that is unable to bind copper ions has been proposed as a pathogenic species causing ALS.
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