Molecular mechanism by which phosphatidylserine regulates recycling endosomal function
Project/Area Number |
16H04782
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Cell biology
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Research Institution | Tohoku University (2018-2019) The University of Tokyo (2016-2017) |
Principal Investigator |
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Project Period (FY) |
2016-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2016: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
|
Keywords | 細胞小器官 / リン脂質 / 物質輸送 / 細胞増殖 / リサイクリングエンドソーム / ホスファチジルセリン / YAP / E3リガーゼ / 自然免疫 / 生体膜 / E3 リガーゼ / オルガネラ / エンドソーム |
Outline of Final Research Achievements |
This study was performed to reveal a novel function of recycling endosomes. I found that recycling endosomes regulate cell proliferation through activation of YAP, an essential transcriptional co-activator for cell proliferation. As a molecular mechanism underlying YAP activation, several recycling endosomal proteins were identified, which include phosphatases that activate YAP through its dephosphorylation and E3 ligases that mediate degradation of Lats that inactivates YAP.
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Academic Significance and Societal Importance of the Research Achievements |
本研究成果は、細胞内物流システム(エンドサイトーシス経路)と細胞増殖シグナル伝達経路(Hippo-YAP経路)のクロストークがあること、そしてそのクロストークの場所がリサイクリングエンドソームであることを示唆している。細胞小器官の新規機能を明らかにしたことに加えて、細胞内物流・細胞内シグナル伝達の両分野に解決すべき新しい課題を提出したという学術的意義を有する。
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Endosomal phosphatidylserine is critical for the YAP signalling pathway in proliferating cells2017
Author(s)
Matsudaira, T., K. Mukai, T. Noguchi, J. Hasegawa, T. Hatta, S. Iemura, T. Natsume, N. Miyamura, H. Nishina, J. Nakayama, K. Semba, T. Tomita, S. Murata, H. Arai, and T. Taguchi
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Journal Title
Nature Communications
Volume: 8(1)
Issue: 1
Pages: 651-651
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Book] 実験医学2019
Author(s)
田口友彦、向井康治朗
Total Pages
10
Publisher
羊土社
ISBN
9784758122412
Related Report
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[Book] 月刊 「細胞」2018
Author(s)
田口友彦、向井康治朗、新井洋由
Total Pages
4
Publisher
ニューサイエンス社
Related Report
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[Book] 実験医学2018
Author(s)
田口友彦、小林俊彦、反町典子、仁木隆裕
Total Pages
5
Publisher
羊土社
ISBN
9784758103718
Related Report
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