| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Outline of Final Research Achievements |
Selective degradation of mitochondria as a whole organelle is a fundamental mechanism conserved beyond species. This autophagy-dependent process, termed mitophagy, contributes to mitochondrial quality and quantity control, and defects in mitophagy are thought to be associated with various pathologies. In this study, we sought to analyze the level and localization of Atg32, a mitophagy-promoting mitochondrial outer membrane protein in budding yeast. We found that prior to acceleration of mitophagy, a fraction of Atg32 is targeted to the endoplasmic reticulum (ER) and ubiquitinated via the ER-associated degradation pathway, resulting in negative regulation of Atg32 protein levels.
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