| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2018: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2017: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2016: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Outline of Final Research Achievements |
This study aimed to investigate how microtubule is assembled in cells: the analyses include those at molecular level, cell level and tissue level. We used fission yeast and human cultured cells to analyze how microtubules are formed, and we have been establishing systems for animal experiments. As a result, we found that Alp7/TACC accelerate microtubule nucleation in cooperation with the gamma-tubulin complex. In addition, our results indicate that there may be Alp7-independent microtubule nucleation system operating in fission yeast cells.
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