| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2019: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2018: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
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| Outline of Final Research Achievements |
Xenopus, a model amphibian, forms a regeneration blastema after limb amputation and then regenerates a limb at last. Xenopus also regenerates skin almost completely after a deep skin injury extent to dermis without forming a scar. We labeled subcutaneous tissues with GFP and indicated that blastema-like cells derived from subcutaneous tissues migrate to the wound and then contribute to skin regeneration. Then, collaborators and I revealed that an Iberian ribbed newt also regenerates skin after deep injury. Furthermore, we identified some groups of genes which are commonly expressed both in limb regeneration and skin regeneration by RNA-seq analysis in Xenupus.
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