| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Outline of Final Research Achievements |
Planar cell polarity (PCP) is the collective alignment of polarized cells within the plane of the epithelium. We previously carried out a genome-wide RNAi screen using the Drosophila notum and identified novel genes involved in multiple developmental processes including PCP. One PCP gene we identified in the RNAi screen is jitterbug (jbug), which is the Drosophila filamin ortholog. However, the molecular mechanism by which Jbug regulates PCP remains unclear. In this study, using fly genetics and live imaging techniques, we elucidated a mechanism underlying PCP defects induced by loss of function of Jbug.
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