| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2018: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
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| Outline of Final Research Achievements |
Three main results have been obtained through studies using Drosophila.1) I identified several candidate genes essential for nutrient-dependent ecdysteroid biosynthesis via controlling the gastric-serotonerginc nerve system (SE0 neurons). 2) I found that the nerve producing the neuropeptide Colazonin is responsible for the negative regulation of purpariation when the flies are in condition of insufficient nutrition. 3) I found that the neuropeptide called Neuropeptide F secreted from the intestine is essential for proliferation control of adult female gremline stem cells. Furthermore, Neuropeptide F was found to be regulated in response to nutrient status, and to be involved in nutrition-dependent germ stem cell proliferation.
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