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Mechanism for mirro-symmetric organogenesis

Research Project

Project/Area Number 16H04797
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Developmental biology
Research InstitutionNational Institute of Genetics

Principal Investigator

Sawa Hitoshi  国立遺伝学研究所, 遺伝形質研究系, 教授 (80222024)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2018: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Keywords細胞移動 / 細胞極性 / 非対称分裂 / Wnt / Frizzled / C. elegans / 器官構築 / 器官形成 / 非対称細胞分裂 / 左右非対称
Outline of Final Research Achievements

Most animals belonging to Bilateria have mirror-symmetric body plan along the left-right axis. However, the mechanisms to produce mirror symmetric organs are poorly understood. In C. elegans, gonad has mirror-symmetric structure along the anterior-posterior axis and shaped by mirror-symmetric migration of DTC cells. This mechanism has not been explored. DTCs are produced by asymmetric divisions of their precursor cells (Z1/Z4). We uncovered that polarity of Z1/Z4 is regulated redundantly by three Wnt proteins and a Wnt receptor that functions Wnt-independently. Furthermore, we showed that migratory direction of DTCs are determined by polarity orientation of their mother cells.

Academic Significance and Societal Importance of the Research Achievements

細胞の移動方向は、細胞外のガイダンス分子によって制御されていると考えられているが、我々の発見はそれ以外に、移動方向がその母細胞の極性によって制御される機構の存在を初めて示した。
また、三種類のWntが極性に対し異なる機能を持っていることを示した。さらに、Wntと冗長的に働くWnt受容体Frizzledが、Wnt結合ドメインである細胞外領域(CRD)否依存的に働くことを初めて発見した。Frizzled蛋白質の新たな機能を明らかにした。
Wntシグナルは哺乳類においても発生や恒常性の維持に重要であり、また癌など様々な疾患にも関与している。Wnt受容体の新たな機能の発見は社会的にも意義が大きい。

Report

(3 results)
  • 2018 Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (3 results)

All 2018 2017 2016

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (1 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] Tumor suppressor APC is an attenuator of spindle-pulling forces duringC. elegansasymmetric cell division2018

    • Author(s)
      Sugioka Kenji、Fielmich Lars-Eric、Mizumoto Kota、Bowerman Bruce、van den Heuvel Sander、Kimura Akatsuki、Sawa Hitoshi
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 115 Issue: 5

    • DOI

      10.1073/pnas.1712052115

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] PIGN prevents protein aggregation in the endoplasmic reticulum independently of its function in the GPI synthesis.2017

    • Author(s)
      Ihara S, Nakayama S, Murakami Y, Suzuki E, Asakawa M, Kinoshita T, Sawa H.
    • Journal Title

      Journal of Cell Science

      Volume: 130 Issue: 3 Pages: 602-613

    • DOI

      10.1242/jcs.196717

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Presentation] Orienting cell polarity by Wnt signaling2016

    • Author(s)
      HItoshi Sawa
    • Organizer
      The 7th Asia-Pasific C. elegans Meeting
    • Place of Presentation
      The Friendship Hotel of Beijing
    • Year and Date
      2016-06-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

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