| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2018: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
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| Outline of Final Research Achievements |
During the formation of the body from a fertilized egg, epithelial cells migrate collectively in the same direction to create a complex organism. However, how epithelial cells can migrate while maintaining cell-to-cell adhesion remains largely a mystery. To understand this mechanism, we focused on the looping morphogenesis of the male genitalia (genitalia rotation) during the Drosophila pupal stage. This genitalia rotation occurs when individual epithelial cells are interchanged asymmetrically and migrate collectively. In the present study, we found that actomyosin, which is localized on the cell adhesion and causes junction remodeling (contraction of the cell adhesion), contributes to the elongation of the newly formed cell adhesion surface on both sides of the dissociated cell. In addition, we show that sidekick, a localized protein of tri-cellular junction (three cell adhesion bond), is involved in this phenomenon.
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