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Identification of the regulatory mechanisms of the ultradian rhythm of migrating motor contraction

Research Project

Project/Area Number 16H04811
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Morphology/Structure
Research InstitutionSaitama University

Principal Investigator

SAKAI TAKAFUMI  埼玉大学, 理工学研究科, 教授 (40235114)

Co-Investigator(Kenkyū-buntansha) 坂田 一郎  埼玉大学, 理工学研究科, 准教授 (80610831)
MONDAL ANUPOM  埼玉大学, 理工学研究科, 助教 (40704531)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
Fiscal Year 2019: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2018: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Keywords消化管運動 / スンクス / ホルモン / ウルトラディアン / ソマトスタチン / オーガンバス / c-fos / ウルトラディアンリズム / モチリン / 迷走神経 / 交感神経 / グレリン
Outline of Final Research Achievements

This study was aimed at identifying the possible mechanisms that regulate an ultradian rhythmic period of 90-120 min intervals of migrating motor contraction (MMC), which propagate from the stomach to the distal intestine, observed in a fasted state by using Suncus murinus. In addition to ghrelin and motilin, cholecystokinin induced gastric contractions. In contrast, somatostatin inhibited gastric contractions. Moreover, gastric contractions were inhibited by activation of the sympathetic nerve. The inhibition of motilin-induced gastric contraction was mediated by GABAergic neurons. Furthermore, we identified that the phase III contraction of MMC was regulated by duodenal pH. Results of the present study offer novel insights into the regulatory mechanism of the ultradian rhythm of MMC.

Academic Significance and Societal Importance of the Research Achievements

本研究はスンクスを用いてウルトラディアンを示すMMCを制御するホルモン、神経及び管腔内情報とその機構について新しい知見を得た。スンクスの小型哺乳動物という利点を活かして、詳細な薬理学的検討を行い、MMCのウルトラディアン調節に関与する新しい知見を得たことは、当該分野の基盤的知見であるため学術的意義は高いと言える。ヒトとスンクスの胃運動は類似していることが知られているので、MMCパターンが異常なヒトの消化管機能疾患患者に対するトランスレーショナル研究に展開していくことが期待される。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (73 results)

All 2019 2018 2017 2016 Other

All Journal Article (17 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 17 results,  Open Access: 9 results,  Acknowledgement Compliant: 5 results) Presentation (51 results) (of which Int'l Joint Research: 11 results,  Invited: 2 results) Remarks (5 results)

  • [Journal Article] Utility of animal gastrointestinal motility and transit models in functional gastrointestinal disorders2019

    • Author(s)
      Al-Saffar Ahmad、Takemi Shota、Saaed Hiwa K.、Sakata Ichiro、Sakai Takafumi
    • Journal Title

      Best Practice & Research Clinical Gastroenterology

      Volume: 40-41 Pages: 101633-101633

    • DOI

      10.1016/j.bpg.2019.101633

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Adenosine stimulates neuromedin U mRNA expression in the rat pars tuberalis2019

    • Author(s)
      Aizawa Sayaka、Gu Tingting、Kaminoda Arisa、Fujioka Ryuya、Ojima Fumiya、Sakata Ichiro、Sakai Takafumi、Ogoshi Maho、Takahashi Sumio、Takeuchi Sakae
    • Journal Title

      Molecular and Cellular Endocrinology

      Volume: 496 Pages: 110518-110518

    • DOI

      10.1016/j.mce.2019.110518

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Generation and characterization of Suncus murinus intestinal organoid: a useful tool for studying motilin secretion2019

    • Author(s)
      Takakura Natsumi、Takemi Shota、Kumaki Shunsuke、Matsumoto Mio、Sakai Takafumi、Iwatsuki Ken、Sakata Ichiro
    • Journal Title

      Cell Biology International

      Volume: 44 Issue: 1 Pages: 62-69

    • DOI

      10.1002/cbin.11201

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular cloning and analysis of Suncus murinus group IIA secretary phospholipase A2 expression2019

    • Author(s)
      Takemi Shota、Nishio Ryo、Taguchi Hayato、Ojima Shiomi、Matsumoto Mio、Sakai Takafumi、Sakata Ichiro
    • Journal Title

      Developmental & Comparative Immunology

      Volume: 100 Pages: 103427-103427

    • DOI

      10.1016/j.dci.2019.103427

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Circulating messenger for neuroprotection induced by molecular hydrogen2019

    • Author(s)
      Noda Mami、Uemura Yuya、Yoshii Yusuke、Horita Taichi、Takemi Shota、Sakata Ichiro、Sakai Takafumi
    • Journal Title

      Canadian Journal of Physiology and Pharmacology

      Volume: 97 Issue: 10 Pages: 909-915

    • DOI

      10.1139/cjpp-2019-0098

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] β-Oxidation in ghrelin-producing cells is important for ghrelin acyl-modifcation2018

    • Author(s)
      Chika Ikenoya, Shota Takemi, Arisa Kaminoda, Sayaka Aizawa, Shiomi Ojima, Zhi Gong, Rakhi Chacrabati, Daisuke Kondo, Reiko Wada, Toru Tanaka, Sachiko Tsuda, Takafumi Sakai, Ichiro Sakata
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 9176-9176

    • DOI

      10.1038/s41598-018-27458-2

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Milk basic protein increases ghrelin secretion and bone mineral density in rodents2017

    • Author(s)
      Yuko Ishida, Rakhi Chacrabati, Aiko Ono-Ohmachi, Zhi Gong, Chika Ikenoya, Sayaka Aizawa, Takayuki Y. Nara, Yoshikazu Morita, Ken Kato, Takafumi Sakai, Ichiro Sakata
    • Journal Title

      Nutrition

      Volume: 39-40 Pages: 15-19

    • DOI

      10.1016/j.nut.2017.02.003

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The important role of ghrelin on gastric contraction in Suncus murinus2017

    • Author(s)
      Takemi S, Sakata I, Kuroda K, Miyano Y, Mondal A, Sakai T.
    • Journal Title

      Endocrine Journal

      Volume: 64

    • NAID

      130007307949

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The study of ghrelin secretion and acyl-modification using mice and ghrelinoma cell lines2017

    • Author(s)
      Sakata I, Gong Z, Ikenoya C, Takemi S, Sakai T.
    • Journal Title

      Endocrine Journal

      Volume: 64 Issue: Suppl. Pages: S27-S29

    • DOI

      10.1507/endocrj.64.S27

    • NAID

      130007307945

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Using a Whole-mount Immunohistochemical Method to Study the Innervation of the Biliary Tract in Suncus murinus.2017

    • Author(s)
      Ren K, Dai Y, Yi K, Kinoshita M, Itoh M, Sakata I, Sakai T, Yi SQ.
    • Journal Title

      Journal of Visualized Experiments

      Volume: 15 Issue: 124

    • DOI

      10.3791/55483

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effect of glutamate on ghrelin release in mice.2017

    • Author(s)
      Rakhi Chacrabati, Zhi Gong, Chika Ikenoya, Daisuke Kondo, Jeffrey M. Zigman, Takafumi Sakai, Ichiro Sakata
    • Journal Title

      Cell Biology International

      Volume: 41(3) Issue: 3 Pages: 320-327

    • DOI

      10.1002/cbin.10728

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Underlying mechanism of the cyclic migrating motor complex in Suncus murinus a change in gastrointestinal pH is the key regulator2017

    • Author(s)
      Anupom Mondal, Kouhei Koyama, Takashi Mikami, Taichi Horita, Shota Takemi, Sachiko Tsuda, Ichiro Sakata & Takafumi Sakai
    • Journal Title

      Physiol Rep.

      Volume: 5(1) Issue: 1 Pages: e13105-e13105

    • DOI

      10.14814/phy2.13105

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The proximal gastric corpus is the most responsive site of motilin-induced contractions in the stomach of the Asian house shrew2016

    • Author(s)
      Amrita Dudani, Sayaka Aizawa, Gong Zhi, Toru Tanaka, Takamichi Jogahara, Ichiro Sakata, Takafumi Sakai
    • Journal Title

      Journal of Comparative Physiology B

      Volume: 185(5) Issue: 5 Pages: 665-675

    • DOI

      10.1007/s00360-016-0985-1

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Molecular cloning of motilin and mechanism of motilin-induced gastrointestinal motility in Japanese quail2016

    • Author(s)
      Auvijit Saha Apu, Anupom Mondal, Takio Kitazawa, Shota Takemi, Takafumi Sakai, Ichiro Sakata
    • Journal Title

      General and Comparative Endocrinology

      Volume: 233 Pages: 53-62

    • DOI

      10.1016/j.ygcen.2016.05.017

    • NAID

      120006666537

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A comparative study of sex difference in calbindin neurons among mice, musk shrews, and Japanese quails.2016

    • Author(s)
      Moe, Y., Tanaka, T., Morishita, M., Ohata, R., Nakahara, C., Kawashima, T., Maekawa, F., Sakata, I., Sakai, T., Tsukahara, S.
    • Journal Title

      Neuroscience Letters

      Volume: 631 Pages: 63-69

    • DOI

      10.1016/j.neulet.2016.08.018

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification of marker genes for pars tuberalis morphogenesis in chick embryo: expression of Cytokine-like 1 and Gap junction protein alpha 5 in pars tuberalis.2016

    • Author(s)
      Aizawa S, Higaki Y, Dudaui A, Nagasaka M, Takahashi S, Sakata I and Sakai T
    • Journal Title

      Cell Tissue Res.

      Volume: 366(3) Issue: 3 Pages: 721-731

    • DOI

      10.1007/s00441-016-2484-9

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Molecular Cloning of Ghrelin and Characteristics of Ghrelin-Producing Cells in the Gastrointestinal Tract of the Common Marmoset (Callithrix jacchus)2016

    • Author(s)
      Shota Takemi, Ichiro Sakata, Auvijit Saha Apu, Shinji Tsukahara, Satowa Yahashi, Goro Katsuura, Fumihiro Iwashige, Atsushi Akune, Akio Inui and Takafumi Sakai
    • Journal Title

      Zoological Science

      Volume: 33(5) Issue: 5 Pages: 497-504

    • DOI

      10.2108/zs160020

    • NAID

      40020960657

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 食虫目スンクスを用いた大腸運動の基盤的研究2019

    • Author(s)
      小林優輝、坂田一郎、小川仁、柴田近、坂井貴文
    • Organizer
      第61回日本平滑筋学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 食虫目スンクス(Suncus murinus)を用いた消化管運動研究の展開2019

    • Author(s)
      竹見祥大、坂田一郎、坂井貴文
    • Organizer
      第61回日本平滑筋学会総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] ラット下垂体主部及び隆起部の糖タンパク質ホルモンαサブユニットの比較解析2019

    • Author(s)
      神之田有紗、坂田一郎、坂井貴文、竹内栄、高橋純夫、相澤清香
    • Organizer
      第44回日本比較内分泌学会及びシンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] 中枢CRF受容体による血糖維持機構の検討2019

    • Author(s)
      木村理紗、竹見祥大、坂井貴文、坂田一郎
    • Organizer
      第44回日本比較内分泌学会及びシンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] アカハライモリのモチリン遺伝子の同定2019

    • Author(s)
      松本実桜、飯島澪、竹見翔大、坂井貴文、坂田一郎
    • Organizer
      第44回日本比較内分泌学会及びシンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] ネッタイツメガエルにおけるニューロメジンU遺伝子の同定と組織分布2019

    • Author(s)
      飯島澪、松本実桜、坂井貴文、坂田一郎
    • Organizer
      第44回日本比較内分泌学会及びシンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] モチリン誘発性強収縮におけるソマトスタチンの抑制作用の研究2019

    • Author(s)
      関谷晏歌、坂田一郎、坂井貴文
    • Organizer
      第44回日本比較内分泌学会及びシンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] スンクスにおける消化管運動に対する生姜の作用検討2019

    • Author(s)
      田口隼人、坂井貴文、坂田一郎
    • Organizer
      第44回日本比較内分泌学会及びシンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] スンクス下垂体前葉主部細胞におけるホルモン産生細胞の形態学的研究2019

    • Author(s)
      高橋直央、塙菫、藤原研、坂井貴文、坂田一郎
    • Organizer
      第44回日本比較内分泌学会及びシンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] スッポン(Pelodiscus sinensis)モチリンの遺伝子クローニングと生理作用の研究2019

    • Author(s)
      齋藤善則、坂田一郎、坂井貴文
    • Organizer
      第44回日本比較内分泌学会及びシンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] Hormonal and neuronal regulatory mechanisms of gastrointestinal motility in the Suncus murinus2019

    • Author(s)
      I.Sakata, T.Sakai
    • Organizer
      9th FAOPS 2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Inhibitory mechanism of motilin-induced strong contraction in conscious Suncus murinus.2018

    • Author(s)
      H.Sekiya, K.koyama, S,Takemi, I.Sakata, T.Sakai
    • Organizer
      3rd Meeting of the Federation of Neurogastroenterology and Motility and Postgraduate Course on Gastrointestinal Motility.(FNM2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cloning of the proglucagon gene and the gastrointestinal motor functions of GLP-1 in Suncus murinus.2018

    • Author(s)
      H.taguchi, S.Ojima, C.Nakahara, N.Hiura, T.Sakai, I.Sakata
    • Organizer
      3rd Meeting of the Federation of Neurogastroenterology and Motility and Postgraduate Course on Gastrointestinal Motility.(FNM2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Corticotropin-releasing factor receptor signaling in the brain stimulates ghrelin secretion via sympathetic nervous system in mice.2018

    • Author(s)
      N. Takakura, D. Kondo, S. Takemi, R.Wada, T. Sakai, I. Sakata
    • Organizer
      International Congress of Neuroendocrinology 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification of the origin of medium chain fatty acid in ghrelin2018

    • Author(s)
      S. Takemi, C. Ikenoya, Z. Gong, D. Kondo, T. Tanaka, T. Sakai, I. Sakata
    • Organizer
      International Congress of Neuroendocrinology 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The mechanism of motilin-induced strong gastric contraction in the Suncus murinus: Involvement of the ghrelin-mediated  GABAergic pathway2018

    • Author(s)
      I.Sakata, S. Takemi, K. Koyama, A. Dudani, T. Sakai
    • Organizer
      International Congress of Neuroendocrinology 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 食虫目スンクスを用いた消化管運動研究2018

    • Author(s)
      坂田一郎、坂井貴文
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 出生後スンクス消化管におけるモチリン及びGLP-1産生細胞の検討2018

    • Author(s)
      西尾凌、坂田一郎、坂井貴文
    • Organizer
      第43回日本比較内分泌学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] β1アドレナリン受容体を介したグレリンによる血糖維持機構の検討2018

    • Author(s)
      木村理紗、近藤大介、竹見祥大、坂井貴文、坂田一郎
    • Organizer
      第43回日本比較内分泌学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 空腹期・食後期における消化管運動機構の解明=新たなモデル動物を用いたアプローチ=2018

    • Author(s)
      坂井貴文
    • Organizer
      第60回日本平滑筋学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Liraglutideによる胃運動/胃排出/適応性弛緩に対する影響の検討の検討2018

    • Author(s)
      竹見祥大、尾島汐海、中原千尋、日浦伸宏、坂井貴文、坂田一郎
    • Organizer
      第60回日本平滑筋学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Determination of proximal corpus as the most active and responsive site for motilin- and ghrelin-induced gastric contractions in suncus murinus stomach in vitro2017

    • Author(s)
      Amrita Dudani, Sayaka Aizawa, Anupom Mondal, Ichiro Sakata, Takafumi Sakai.
    • Organizer
      ANMA & JSNM Joint Meeting 2017
    • Place of Presentation
      Osaka International Convention Center, (大阪府、大阪市)
    • Year and Date
      2017-03-23
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ウズラにおけるセロトニン誘導性消化管収縮運動調節メカニズムの検討2017

    • Author(s)
      ハ・ライ、ドゥダニ・アムリタ、坂井田初季、竹見祥大、坂井貴文、坂田一郎
    • Organizer
      第41回鳥類内分泌研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 食虫目スンクスプログルカゴン遺伝子のクローニングと消化管GLP-1発現・産生領域の検討2017

    • Author(s)
      尾島汐海、坂井貴文、坂田一郎
    • Organizer
      第42回日本比較内分泌学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] スンクス消化管におけるLysozyme産生細胞の局在の検討2017

    • Author(s)
      竹見祥大、坂井貴文、坂田一郎
    • Organizer
      第42回日本比較内分泌学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] スンクスにおけるモチリン誘発性強収縮機構の検討2017

    • Author(s)
      小山航平、竹見祥大、田中亨、坂田一郎、坂井貴文
    • Organizer
      第42回日本比較内分泌学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] スンクス消化管運動におけるコレシストキニン(CCK)の生理作用とCCKA 受容体遺伝子の同定2017

    • Author(s)
      本田航、坂田一郎、坂井貴文
    • Organizer
      第88回 日本動物学会 富山大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] スンクス上部小腸オルガノイド培養系の確立2017

    • Author(s)
      高倉なつみ、竹見祥大、熊木竣佑、岩槻健、坂井貴文
    • Organizer
      第88回 日本動物学会 富山大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] スンクス消化管における食後期収縮制御機構の検討2017

    • Author(s)
      竹見 祥大、伊藤 一真、三上 堯、小山 航平、黒田 香百合、Anupon Mondal、 坂田 一郎、坂井 貴文
    • Organizer
      第59回 日本平滑筋学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Adenosine and dopamine are key regulatory molecules for motilin-induced contractions in the Asian musk shrew  stomach Suncus murinus in-vitro2017

    • Author(s)
      ウダニ アムリタ、モンダル アヌポン、坂田 一郎、坂井 貴文
    • Organizer
      第59回 日本平滑筋学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 食虫目スンクス下垂体前葉におけるホルモン産生細胞の局在及び精巣摘除によるLH産生細胞の形態学的変化の研究2017

    • Author(s)
      坂井田初季、相澤清香、坂田一郎、坂井貴文
    • Organizer
      第32回 日本下垂体研究会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] The important role of ghrelin on gastric contraction in Suncus murinus2017

    • Author(s)
      Shota Takemi, Ichiro Sakata, Kayuri Kuroda, Takafumi Sakai
    • Organizer
      International Symposium on Ghrelin and Energy Metabolism Homeostasis
    • Related Report
      2017 Annual Research Report
  • [Presentation] The study of ghrelin secretion and acyl-modification using mice and ghrelinoma cell lines2017

    • Author(s)
      Ichiro Sakata, Zhi Gong, Chika Ikenoya, Shota Takemi, Takahumi Sakai
    • Organizer
      International Symposium on Ghrelin and Energy Metabolism Homeostasis
    • Related Report
      2017 Annual Research Report
  • [Presentation] モチリン発現を調節する転写因子の探索2017

    • Author(s)
      PENA MARTINEZ CRISTIAN DAVID, 坂井貴文、坂田一郎
    • Organizer
      日本動物学会関東支部第69回大会
    • Place of Presentation
      筑波大学東京キャンパス (東京都、文京区)
    • Related Report
      2016 Annual Research Report
  • [Presentation] CLARITYによる消化管組織透明化及びグレリン産生細胞の三次元的観察2017

    • Author(s)
      日浦伸宏、坂田一郎、津田佐知子、坂井貴文
    • Organizer
      日本動物学会関東支部第69回大会
    • Place of Presentation
      筑波大学東京キャンパス (東京都、文京区)
    • Related Report
      2016 Annual Research Report
  • [Presentation] グレリンを修飾する中鎖脂肪酸の起源の同定2016

    • Author(s)
      竹見祥大 、池之谷知佳 、Gong zhi、Chakrabati Rakhi、近藤大介 、田中 亨 、坂井貴文、坂田一郎
    • Organizer
      第41回日本比較内分泌学会大会
    • Place of Presentation
      北里大学相模原キャンパス (神奈川県、相模原市)
    • Year and Date
      2016-12-09
    • Related Report
      2016 Annual Research Report
  • [Presentation] ウロコルチン 1 脳室内投与によるグレリン分泌作用の検討2016

    • Author(s)
      近藤大介、上田洸平、坂井貴文、坂田一郎
    • Organizer
      第41回日本比較内分泌学会大会
    • Place of Presentation
      北里大学相模原キャンパス (神奈川県、相模原市)
    • Year and Date
      2016-12-09
    • Related Report
      2016 Annual Research Report
  • [Presentation] 食虫目スンクスを用いた胃容量測定系の確立2016

    • Author(s)
      中原千尋、伊藤一真、坂田一郎、坂井貴文
    • Organizer
      第41回日本比較内分泌学会大会
    • Place of Presentation
      北里大学相模原キャンパス (神奈川県、相模原市)
    • Year and Date
      2016-12-09
    • Related Report
      2016 Annual Research Report
  • [Presentation] スンクスにおける中枢性胃運動調節機構の検討2016

    • Author(s)
      堀田太一、伊藤一真、小山航平、三上 尭、坂田一郎、坂井貴文
    • Organizer
      第41回日本比較内分泌学会大会
    • Place of Presentation
      北里大学相模原キャンパス (神奈川県、相模原市)
    • Year and Date
      2016-12-09
    • Related Report
      2016 Annual Research Report
  • [Presentation] モチリン及びグレリンによる協調的摂食刺激作用の検討2016

    • Author(s)
      尾島汐海、中村友亮、坂田一郎、坂井貴文
    • Organizer
      第41回日本比較内分泌学会大会
    • Place of Presentation
      北里大学相模原キャンパス (神奈川県、相模原市)
    • Year and Date
      2016-12-09
    • Related Report
      2016 Annual Research Report
  • [Presentation] 食虫目スンクスにおける下垂体前葉ホルモン産生細胞の局在の検討2016

    • Author(s)
      坂井田初季、相澤清香、坂田一郎 、坂井貴文
    • Organizer
      第41回日本比較内分泌学会大会
    • Place of Presentation
      北里大学相模原キャンパス (神奈川県、相模原市)
    • Year and Date
      2016-12-09
    • Related Report
      2016 Annual Research Report
  • [Presentation] マウスグレリン産生細胞における RESP18 の役割の検討2016

    • Author(s)
      牧井 崇、池之谷知佳、竹見祥大、坂井貴文、坂田一郎
    • Organizer
      第41回日本比較内分泌学会大会
    • Place of Presentation
      北里大学相模原キャンパス (神奈川県、相模原市)
    • Year and Date
      2016-12-09
    • Related Report
      2016 Annual Research Report
  • [Presentation] The role of vagal TRPV1 in gastric acidification suppression of motilin-induced gastric contractions2016

    • Author(s)
      小山航平、吉村真、三上尭、アヌポンモンダル、坂田一郎、坂井貴文
    • Organizer
      The 11th Anniversary India-Japan Fest BICON-2016
    • Place of Presentation
      Biyani Girls College (インド、ジャイプール)
    • Year and Date
      2016-10-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] (3)Sympathetic nerve stimulates ghrelin secretion via its interaction with urocortin in mice.2016

    • Author(s)
      近藤大介、上田洸平、竹見祥大、池之谷知佳、坂井貴文、坂田一郎
    • Organizer
      The 11th Anniversary India-Japan Fest BICON-2016
    • Place of Presentation
      Biyani Girls College (インド、ジャイプール)
    • Year and Date
      2016-10-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Determination of main action site of motilin in Suncus murinus in vitro.2016

    • Author(s)
      A Dudani、A Mondal、S Aizawa、I Sakata、T Sakai
    • Organizer
      The 11th Anniversary India-Japan Fest BICON-2016
    • Place of Presentation
      Biyani Girls College (インド、ジャイプール)
    • Year and Date
      2016-10-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Proximal stomach is the most responsive site for motilin- and ghrelin-induced gastric contractions in Asian musk shrew stomach in vitro.2016

    • Author(s)
      A Dudani, S Aizawa, A Mondal, T Sakai, I Sakata,
    • Organizer
      FNM 2016 Joint International Meeting, San Francisco, California, USA.
    • Place of Presentation
      Hyatt Regency San Francisco (アメリカ合衆国、サンフランシスコ)
    • Year and Date
      2016-08-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Changes of duodenal pH are important for the occurrence of strong gastric contraction by the release of motilin in the Suncus murinus.2016

    • Author(s)
      (6)A Mondal, K Koyama, T Mikami, I Sakata, T Sakai,
    • Organizer
      FNM 2016 Joint International Meeting, San Francisco, California, USA.
    • Place of Presentation
      Hyatt Regency San Francisco (アメリカ合衆国、サンフランシスコ)
    • Year and Date
      2016-08-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] モチリン誘発性強収縮の胃内酸性化による抑制機構における迷走神経とTRPV1の役割2016

    • Author(s)
      小山航平、吉村真、三上尭、黒田香百合、西田麻希、伊藤一真、アヌポンモンダル、城ヶ原貴通、坂田一郎、坂井貴文
    • Organizer
      第58回日本平滑筋学会総会
    • Place of Presentation
      東北医科薬科大学 (宮城県、仙台市)
    • Year and Date
      2016-08-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] Alternation of duodenal pH by 5HT4 recepter governs motilin release and induction of gastric phase Ⅲ-like contraction in Suncus murinus2016

    • Author(s)
      アヌポンモンダル、小山航平、三上尭、坂田一郎、坂井貴文
    • Organizer
      第58回日本平滑筋学会総会
    • Place of Presentation
      東北医科薬科大学 (宮城県、仙台市)
    • Year and Date
      2016-08-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] Most Active And Responsive Site For Motilin- And Ghrelin-Induced Gastric Contractions Is Proximal Stomach In Asian Musk Shrew Stomach In Vitro.2016

    • Author(s)
      A Dudani, S Aizawa, A Mondal, T Sakai, I Sakata
    • Organizer
      7th ISAJ Symposium
    • Place of Presentation
      インド大使館 (東京都、千代田区)
    • Related Report
      2016 Annual Research Report
  • [Presentation] ウロコルチン1脳室内投与によるグレリン分泌作用の検討2016

    • Author(s)
      近藤大介、竹見祥大、Rakhi Chacrabati、坂井貴文、坂田一郎
    • Organizer
      第22回Hindgut Club Japanシンポジウム
    • Place of Presentation
      専修大学 (東京都、千代田区)
    • Related Report
      2016 Annual Research Report
  • [Remarks] 埼玉大学理学部生体制御学科細胞制御学研究室

    • URL

      http://cell.seitai.saitama-u.ac.jp/

    • Related Report
      2019 Annual Research Report
  • [Remarks] 埼玉大学理学部生体制御学科ホームページ

    • URL

      http://seitai.saitama-u.ac.jp/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 埼玉大学理学部生体制御学科細胞制御学研究室ホームページ

    • URL

      http://cell.seitai.saitama-u.ac.jp/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 埼玉大学理学部生体制御学科

    • URL

      http://seitai.saitama-u.ac.jp/results.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 埼玉大学大学院理工学研究科細胞制御学研究室

    • URL

      http://cell.seitai.saitama-u.ac.jp/

    • Related Report
      2016 Annual Research Report

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Published: 2016-04-21   Modified: 2022-12-28  

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