| Budget Amount *help |
¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
Fiscal Year 2019: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2018: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
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| Outline of Final Research Achievements |
This study was aimed at identifying the possible mechanisms that regulate an ultradian rhythmic period of 90-120 min intervals of migrating motor contraction (MMC), which propagate from the stomach to the distal intestine, observed in a fasted state by using Suncus murinus. In addition to ghrelin and motilin, cholecystokinin induced gastric contractions. In contrast, somatostatin inhibited gastric contractions. Moreover, gastric contractions were inhibited by activation of the sympathetic nerve. The inhibition of motilin-induced gastric contraction was mediated by GABAergic neurons. Furthermore, we identified that the phase III contraction of MMC was regulated by duodenal pH. Results of the present study offer novel insights into the regulatory mechanism of the ultradian rhythm of MMC.
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