Identification of the regulatory mechanisms of the ultradian rhythm of migrating motor contraction
| Project/Area Number |
16H04811
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphology/Structure
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| Research Institution | Saitama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
坂田 一郎 埼玉大学, 理工学研究科, 准教授 (80610831)
MONDAL ANUPOM 埼玉大学, 理工学研究科, 助教 (40704531)
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
Fiscal Year 2019: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2018: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
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| Keywords | 消化管運動 / スンクス / ホルモン / ウルトラディアン / ソマトスタチン / オーガンバス / c-fos / ウルトラディアンリズム / モチリン / 迷走神経 / 交感神経 / グレリン |
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| Outline of Final Research Achievements |
This study was aimed at identifying the possible mechanisms that regulate an ultradian rhythmic period of 90-120 min intervals of migrating motor contraction (MMC), which propagate from the stomach to the distal intestine, observed in a fasted state by using Suncus murinus. In addition to ghrelin and motilin, cholecystokinin induced gastric contractions. In contrast, somatostatin inhibited gastric contractions. Moreover, gastric contractions were inhibited by activation of the sympathetic nerve. The inhibition of motilin-induced gastric contraction was mediated by GABAergic neurons. Furthermore, we identified that the phase III contraction of MMC was regulated by duodenal pH. Results of the present study offer novel insights into the regulatory mechanism of the ultradian rhythm of MMC.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究はスンクスを用いてウルトラディアンを示すMMCを制御するホルモン、神経及び管腔内情報とその機構について新しい知見を得た。スンクスの小型哺乳動物という利点を活かして、詳細な薬理学的検討を行い、MMCのウルトラディアン調節に関与する新しい知見を得たことは、当該分野の基盤的知見であるため学術的意義は高いと言える。ヒトとスンクスの胃運動は類似していることが知られているので、MMCパターンが異常なヒトの消化管機能疾患患者に対するトランスレーショナル研究に展開していくことが期待される。
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Report
(5 results)
Research Products
(73 results)
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[Journal Article] β-Oxidation in ghrelin-producing cells is important for ghrelin acyl-modifcation2018
Author(s)
Chika Ikenoya, Shota Takemi, Arisa Kaminoda, Sayaka Aizawa, Shiomi Ojima, Zhi Gong, Rakhi Chacrabati, Daisuke Kondo, Reiko Wada, Toru Tanaka, Sachiko Tsuda, Takafumi Sakai, Ichiro Sakata
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Journal Title
Scientific Reports
Volume: 8
Issue: 1
Pages: 9176-9176
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Milk basic protein increases ghrelin secretion and bone mineral density in rodents2017
Author(s)
Yuko Ishida, Rakhi Chacrabati, Aiko Ono-Ohmachi, Zhi Gong, Chika Ikenoya, Sayaka Aizawa, Takayuki Y. Nara, Yoshikazu Morita, Ken Kato, Takafumi Sakai, Ichiro Sakata
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Journal Title
Nutrition
Volume: 39-40
Pages: 15-19
DOI
Related Report
Peer Reviewed
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[Journal Article] A comparative study of sex difference in calbindin neurons among mice, musk shrews, and Japanese quails.2016
Author(s)
Moe, Y., Tanaka, T., Morishita, M., Ohata, R., Nakahara, C., Kawashima, T., Maekawa, F., Sakata, I., Sakai, T., Tsukahara, S.
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Journal Title
Neuroscience Letters
Volume: 631
Pages: 63-69
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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