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Studies on neural basis of prediction error learning theory in insects

Research Project

Project/Area Number 16H04814
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Animal physiology/Animal behavior
Research InstitutionHokkaido University

Principal Investigator

Mizunami Makoto  北海道大学, 理学研究院, 教授 (30174030)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2018: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Keywords学習 / 昆虫 / 微小脳 / 報酬 / 罰 / 予測誤差 / オクトパミン / ドーパミン / 報酬学習 / 報酬予測誤差 / コオロギ / ゴキブリ / パブロフ型条件付け / 古典的条件付け / パブロフ型条件づけ / ニューロン / 脳 / 神経行動学 / 神経科学
Outline of Final Research Achievements

I obtained four major findings in this study. At first, I showed that aversive learning in crickets can be accounted for by the prediction error theory. Secondly, I obtained evidence to suggest that dopamine neurons mediate aversive prediction error signals. Thirdly, I was successful to morphologically characterized octopamine-immunoreactive neurons that are likly to convey information about prediction error signals in appetitive learning in cockroaches. Finally, I showed that some features of learning in crickets cannot be accounted for by prediction error theory. In conclusion, I showed applicability of the predictor error to insect learning and also its limitations, and clarified some of its neural basis.

Academic Significance and Societal Importance of the Research Achievements

本研究は、昆虫の学習の主要な特徴が予測誤差理論で説明できることを初めて明らかにし、またそのニューロン機構の一端を明らかにした画期的なもので、学術的に高い意義がある。
また本研究は、学習の基本アルゴリズムが昆虫と哺乳類の間で共通であることを明らかにし、動物の脳の進化の理解の鍵となる知見をもたらしたもので、社会的にも大きなインパクトを与えうるものである。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (47 results)

All 2018 2017 2016 Other

All Journal Article (11 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 11 results,  Open Access: 7 results,  Acknowledgement Compliant: 4 results) Presentation (30 results) (of which Int'l Joint Research: 8 results,  Invited: 7 results) Book (4 results) Remarks (2 results)

  • [Journal Article] Signaling pathways for long-term memory formation in the cricket2018

    • Author(s)
      Matsumoto Y, Matsumoto CS, Mizunami M.
    • Journal Title

      Front. Psychol.

      Volume: 9 Pages: 1014-1014

    • DOI

      10.3389/fpsyg.2018.01014

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Application of a Prediction Error Theory to Pavlovian Conditioning in an Insect2018

    • Author(s)
      Mizunami Makoto、Terao Kanta、Alvarez Beatriz
    • Journal Title

      Frontiers in Psychology

      Volume: 9 Pages: 1272-1272

    • DOI

      10.3389/fpsyg.2018.01272

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Spatial receptive fields for odor localization2018

    • Author(s)
      Nishino H., Iwasaki M., Paoli M., Kamimura I., Yoritsune A., Mizunami M.
    • Journal Title

      Current Biology

      Volume: 28 Issue: 4 Pages: 600-608

    • DOI

      10.1016/j.cub.2017.12.055

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Tyrosine hydroxylase-immunoreactive neurons in the mushroom body of the field cricket, Gryllus bimaculatus2018

    • Author(s)
      Hamanaka Yoshitaka、Mizunami Makoto
    • Journal Title

      Cell and Tissue Research

      Volume: 376 Issue: 1 Pages: 1-1

    • DOI

      10.1007/s00441-018-2969-9

    • NAID

      120006820172

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of dopamine neurons in mediating the prediction error in aversive learning in insects2017

    • Author(s)
      Terao Kanta、Mizunami Makoto
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 14694-14694

    • DOI

      10.1038/s41598-017-14473-y

    • NAID

      120006370603

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Two parallel olfactory pathwary for processing general odors in a cockroach2017

    • Author(s)
      Watanabe H, Nishino H. Mizunami M. Yokohari F.
    • Journal Title

      Frontiers in Neural Circuits

      Volume: 11 Pages: 32-32

    • DOI

      10.3389/fncir.2017.00032

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Group-housed females promote production of asexual ootheca in American cockroaches2017

    • Author(s)
      Katoh K., Iwasaki M., Hosono S., Yoritsue A., Ochiai M., Mizunami M., Nishino H.
    • Journal Title

      Zoological Letters

      Volume: 3 Issue: 1 Pages: 3-3

    • DOI

      10.1186/s40851-017-0063-x

    • NAID

      120005981462

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Complete identification of four giant interneuronssupplying mushroom body calyces in the cockroach Periplaneta americana2017

    • Author(s)
      Takahashi N., Katoh K., Watanabe H., Nakayama Y., Iwasaki M., Mizunami M., Nishino H.
    • Journal Title

      Journal of Comparative Neurology

      Volume: 525 Issue: 1 Pages: 204-230

    • DOI

      10.1002/cne.24108

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Roles of octopamine and dopamine neurons for mediating appetitive and aversive signals in Pavlovian conditioning in crickets2017

    • Author(s)
      M. Mizunami and Y. Matsumoto
    • Journal Title

      Frontier in Physiology

      Volume: 8 Pages: 1027-1027

    • DOI

      10.3389/fphys.2017.01027

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Searching for cognitive processes underlying insect learning2017

    • Author(s)
      Mizunami M, Matsumoto C-S, Matsumoto Y.
    • Journal Title

      Japanese Journal of Animal Psychology

      Volume: 67 Issue: 1 Pages: 1-10

    • DOI

      10.2502/janip.67.1.5

    • NAID

      130006894416

    • ISSN
      0916-8419, 1880-9022
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interaction of inhibitory and facilitatory effects of conditioning trials on long-term memory formation2016

    • Author(s)
      Hosono S, Matsumoto Y, Mizunami M.
    • Journal Title

      Learning & Memory

      Volume: 23 Issue: 12 Pages: 669-678

    • DOI

      10.1101/lm.043513.116

    • NAID

      120006366476

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Roles of a transcription repressor FoxP in the long-term memory formation in crickets.2018

    • Author(s)
      Yaolong Li, Takayuki Watanabe & Makoto Mizunami.
    • Organizer
      日本比較生理生化学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Validity of stimulus enhancement in explaining theory the social learning in crickets.2018

    • Author(s)
      Hiroki Ebina & Makoto Mizunami.
    • Organizer
      日本比較生理生化学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Low context-dependency of “habitual memory” formed by extended classical conditioning training in crickets.2018

    • Author(s)
      Misato Sato and Makoto Mizunami.
    • Organizer
      日本比較生理生化学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Inhibitory learning in a cricket; extinction and overexpectation.2018

    • Author(s)
      Kanta Terao, Beatritz Alvarez & Makoto Mizunami.
    • Organizer
      日本比較生理生化学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Associative learning as a research tool for the study of cognition and behaviour in the cricket Gryllus bimaculatus.2018

    • Author(s)
      Beatriz Alvarez, Hiroki Ebina, Kanta Terao, Yukihisa Matsumoto, Makoto Mizunami
    • Organizer
      International Congress of the Spanish Society of Ethology and Evolutionary Ecology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Inhibitory learning in the cricket Gryllus bimaculatus.2018

    • Author(s)
      Beatriz Alvarez, Kanta Terao, Yukihisa Matsumoto, & Makoto Mizunami.
    • Organizer
      XXX International Conference of the Spanish Society for Comparative Psychology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Associative learning in the cricket Gryllus bimaculatus.2018

    • Author(s)
      Beatriz Alvarez, Hiroki Ebina, Kanta Terao, Yukihisa Matsumoto, & Makoto Mizunami.
    • Organizer
      XXX International Conference of the Spanish Society for Comparative Psychology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Roles of a transcription factor FoxP in olfactory learning in crickets.2018

    • Author(s)
      Li Yaolong, Takayuki Watanabe, Makoto Mizunami
    • Organizer
      日本動物学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] コオロギの社会学習のAppetitive learning とaversive learningについて2018

    • Author(s)
      蝦名宥輝, 水波誠
    • Organizer
      日本動物学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 虫脳性決定機構の進化を探る~doublesex 遺伝子はコオロギ脳の性を決めるのか?2018

    • Author(s)
      渡邊崇之、水波誠
    • Organizer
      日本動物学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] コオロギの古典的条件づけにおける習慣的記憶のコンテキスト依存性2018

    • Author(s)
      佐藤深怜、水波誠
    • Organizer
      日本動物学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 微小脳と巨大脳:昆虫脳とヒト脳の共通起源と進化2018

    • Author(s)
      水波誠
    • Organizer
      日本臨床脳神経外科学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Contacts with nest mates maintain the dangerous aggressiveness for social defenses in an ant.2018

    • Author(s)
      Eisuke Hasegawa, Hitoshi Aonuma, Kanta Terao, Natsuki Ogusu, Saori Watanabe, Syunta Mikami, Yusuke Fujita, Makoto Mizunami and Yuuka Murakami
    • Organizer
      13th Japanese Drosophila Research Conference、2018年9月10-12日
    • Related Report
      2018 Annual Research Report
  • [Presentation] Functional relationships between feedback neurons and output neurons in the mushroom body of the cockroach brain.2017

    • Author(s)
      Naomi Takahashi, Makoto Mizunami
    • Organizer
      Gordon Research Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] アリは巣仲間と交流してストレスから回復する2017

    • Author(s)
      2)長谷川英祐、青沼仁志、寺尾勘太、小楠なつき、大久保祐作、渡邊紗織、三上俊太、藤田悠介、水波誠、村上優花
    • Organizer
      行動2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] コオロギの罰学習におけるブロッキング現象2017

    • Author(s)
      寺尾勘太、水波誠
    • Organizer
      日本動物学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ワモンゴキブリ高次嗅覚中枢に入力する巨大GABA作動性ニューロンの生理学的解析2017

    • Author(s)
      高橋直美、水波誠
    • Organizer
      日本動物学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Habit formation by extended Pavlovian training in crickets.2017

    • Author(s)
      Makoto Mizunami
    • Organizer
      Naito Conference on decision making in the brain
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prediction error theory in insects.2017

    • Author(s)
      Kanta Terao、Makoto Mizunami
    • Organizer
      Naito Conference on decision making in the brain,
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prediction error theory in insects; comparative analyses produce insights for general learning rules2017

    • Author(s)
      寺尾勘太・水波誠
    • Organizer
      基礎心理学会、若手オーラルセッション
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] コオロギ古典的条件付けにおける習慣形成2017

    • Author(s)
      水波誠
    • Organizer
      ConBio2017
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Contrasting social learning with live and dead conspecifics in cricket.2017

    • Author(s)
      Yuki Ebina, Makoto Mizunami
    • Organizer
      日本比較生理生化学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] コオロギの学習研究から何を学ぶか?2016

    • Author(s)
      水波誠
    • Organizer
      日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-12-02
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Searching for cognitive processes involved in insect learning2016

    • Author(s)
      Makoto Mizunami
    • Organizer
      日本動物心理学会
    • Place of Presentation
      北海道大学(北海道札幌市)
    • Year and Date
      2016-11-24
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Critical evidence for the prediction error theory in the insect learning2016

    • Author(s)
      Kanta Terao, Makoto Mizunami
    • Organizer
      日本動物心理学会
    • Place of Presentation
      北海道大学(北海道札幌市)
    • Year and Date
      2016-11-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] Complete identification of four calycal giant interneurons in an insect brain2016

    • Author(s)
      Naomi Takahashi, Ko Katoh, Hidehiro Watanabe, Makoto Mizunami, Hiroshi Nishino.
    • Organizer
      International Congress of Zoology
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県宜野湾市)
    • Year and Date
      2016-11-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Different social learning from live and dead conspecifics in crickets.2016

    • Author(s)
      Hiroki Ebina, Makoto Mizunami,
    • Organizer
      International Congress of Zoology
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県宜野湾市)
    • Year and Date
      2016-11-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Aggregation pheromone processing in a cockroach brain.2016

    • Author(s)
      Ko Katoh, Naomi Takahashi, Hidehiro Watanabe, Makoto Mizunami, Hiroshi Nishino
    • Organizer
      日本比較生理生化学会
    • Place of Presentation
      玉川大学(東京都町田市)
    • Year and Date
      2016-09-04
    • Related Report
      2016 Annual Research Report
  • [Presentation] Immunohistochemistry with α-TDC2 antibodies in the cockroach brain.2016

    • Author(s)
      Kanta Terao, Takayuki Watanabe, Hitoshi Aonuma, Hiroshi Nishino, Makoto Mizunami.
    • Organizer
      日本比較生理生化学会
    • Place of Presentation
      玉川大学(東京都町田市)
    • Year and Date
      2016-09-04
    • Related Report
      2016 Annual Research Report
  • [Presentation] Studies on structure and function of insect microbrain2016

    • Author(s)
      Makoto Mizunami
    • Organizer
      日本比較生理生化学会
    • Place of Presentation
      玉川大学(東京都町田市)
    • Year and Date
      2016-09-03
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Book] 動物学の百科事典2018

    • Author(s)
      公益社団法人日本動物学会(執筆者に水波誠を含む)
    • Total Pages
      770
    • Publisher
      丸善出版
    • ISBN
      4621303090
    • Related Report
      2018 Annual Research Report
  • [Book] 脳の神秘を探ってみよう2017

    • Author(s)
      水波誠
    • Total Pages
      10
    • Publisher
      朝日新聞出版
    • ISBN
      4023315834
    • Related Report
      2017 Annual Research Report
  • [Book] The Cricket as a Model Organism: Development, Regeneration, and Behavior2017

    • Author(s)
      Matsumoto Y, Matsumoto CS and Mizunami M
    • Total Pages
      12
    • Publisher
      Springer, Tokyo.
    • ISBN
      4431564764
    • Related Report
      2017 Annual Research Report
  • [Book] Bioinspired Actuators and Sensors2016

    • Author(s)
      Taya M, Vonkenburgh EV, Mizunami M, Nomura S.
    • Total Pages
      523
    • Publisher
      Cambridge Univ Press
    • Related Report
      2016 Annual Research Report
  • [Remarks] 水波研究室ホームページ

    • URL

      https://www.sci.hokudai.ac.jp/~mizunami/MICROB~2/intro.html

    • Related Report
      2018 Annual Research Report
  • [Remarks]

    • URL

      https://www.sci.hokudai.ac.jp/~mizunami/MICROB~2/index.html

    • Related Report
      2017 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

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