| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2018: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2016: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
Metamorphosis allows animals to convert their various aspects such as body shape, physiology, gene expression, behavior, life style and environment. How the timing of these metamorphic changes are regulated by the neuronal and endocrine systems is the important question for understanding animal metamorphosis? To address this issue, we characterized regulatory network of the metamorphosis in the ascidian. We identified the neurotransmitter GABA is essential for the whole metamorphic events of ascidian. GABA uses its metabotropic receptor for initiating metamorphosis. GnRH is the downstream molecule of GABA for initiating tail regression. The other metamorphic event of ascidian, growth of adult organs is regulated by a portion of GnRH and thyroid hormone. Our findings are necessary for understanding the nature of animal metamorphosis.
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