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Origins and Evolution of Chordates: Studies of Comparative Genomics and Evolutionary Developmental Biology

Research Project

Project/Area Number 16H04824
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Evolutionary biology
Research InstitutionOkinawa Institute of Science and Technology Graduate University

Principal Investigator

SATOH NORIYUKI  沖縄科学技術大学院大学, マリンゲノミックスユニット, 教授 (30025481)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2018: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Keywords脊索動物の起源と進化 / 脊索 / 体節 / 遺伝子重複 / セルロース合成遺伝子 / 水平伝播 / 脊索動物の進化 / 比較ゲノム科学 / 進化発生生物学 / 発生進化学 / 比較発生学 / 脊索動物の起源 / 幼生型の変化 / 筋肉 / 比較ゲノム / Brachyury
Outline of Final Research Achievements

In order to understand the origin and evolution of chordates, comparative analyses of orthologous genes that are involved in the formation of fish-like larvae are essential. In this study, we developed a new web tool named "ORTHOSCOPE". Taking advantage of this tool, the present study has explored following things. (a) Fish-like larvae develop somite muscle, which is not found in non-chordate deuterostomes. The ORTHOSCOPE analysis indicated that duplications of genes that encode actin or myosin heavy-chain resulted in the formation of muscle-type protein genes, which are involved in chordate-type muscle formation. (b) Tunicates are only animal group that can synthesize cellulose by themselves. The ORTHOSCOPE analysis indicated that CesA (cellulose synthase genes) are only found in tunicate genomes but not in other animal genomes. This strongly suggests that horizontal gene transfer of CesA occurred in the ancestor of tunicates and allowed tunicates to evolve as a specific group.

Academic Significance and Societal Importance of the Research Achievements

脊索動物の起源と進化の問題に対して、比較ゲノム科学的にチャレンジした。そのための前提として、脊索動物およびその近縁の棘皮動物・半索動物のゲノムを解読する必要があり、それらを解読した上でこの研究に臨んでいるところに本研究の大きな特徴がある。そして遺伝子の比較を容易にするために、まずORTHOSCOPEというウエッブ・ツールを開発した。そしてこの方法によって、脊索動物を特徴付ける脊索や筋肉がどのように生まれたのかの遺伝子的基盤を明らかにした。また、これまで亜門とされてきた脊索動物の3群、頭索動物、尾索動物、脊椎動物を門として提唱するという段階にまで至ったことの学術的意義は大きい。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (9 results)

All 2019 2018 2017 2016 Other

All Journal Article (5 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 5 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (2 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results) Book (1 results) Remarks (1 results)

  • [Journal Article] ORTHOSCOPE Analysis Reveals the Presence of the Cellulose Synthase Gene in All Tunicate Genomes but Not in Other Animal Genomes2019

    • Author(s)
      Jun Inoue, Keisuke Nakashima, and Noriyuki Satoh
    • Journal Title

      Genes

      Volume: 10 Issue: 4 Pages: 1-9

    • DOI

      10.3390/genes10040294

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The phylum Vertebrata: a case for zoological recognition.2018

    • Author(s)
      Irie, N., Kuratani, S., and Satoh, N.
    • Journal Title

      Zoological Lett

      Volume: 4 Issue: 1 Pages: 32-32

    • DOI

      10.1186/s40851-018-0114-y

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ORTHOSCOPE: An Automatic Web Tool for Phylogenetically Inferring Bilaterian Orthogroups with User-Selected Taxa2018

    • Author(s)
      Inoue Jun、Satoh Noriyuki
    • Journal Title

      Molecular Biology and Evolution

      Volume: 36 Issue: 3 Pages: 621-631

    • DOI

      10.1093/molbev/msy226

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Deuterostome genomics: Lineage-specific protein expansions that enabled chordate muscle evolution.2018

    • Author(s)
      Inoue, J., Satoh, N.
    • Journal Title

      Molecular Biology and Evolution.

      Volume: 35 Issue: 4 Pages: 914-924

    • DOI

      10.1093/molbev/msy002

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The chordate ancestor possessed a single copy of the Brachyury gene for notochord aquisition2017

    • Author(s)
      Inoue, J., Yasuoka, Y., Takahashi, H. Satoh, N.
    • Journal Title

      Zoological Letters

      Volume: 3 Issue: 1 Pages: 4-4

    • DOI

      10.1186/s40851-017-0064-9

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Genome evolution involved in Chordate Origins2017

    • Author(s)
      Satoh, N.
    • Organizer
      Genome Evolution at Mishima
    • Place of Presentation
      Mishima, Japan
    • Year and Date
      2017-03-27
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Chordate origins and evolution: Suggestion from urochordates2017

    • Author(s)
      Satoh, N.
    • Organizer
      Annual Meeting of Zoological Society of Japab
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Book] Chordate Orgins and Evolution2016

    • Author(s)
      Noriyuki Satoh
    • Total Pages
      206
    • Publisher
      Academic Press (Elsevier)
    • Related Report
      2016 Annual Research Report
  • [Remarks] OISTマリンゲノミックスユニット

    • URL

      https://groups.oist.jp/mgu

    • Related Report
      2018 Annual Research Report

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Published: 2016-04-21   Modified: 2020-03-30  

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