| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2018: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
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| Outline of Final Research Achievements |
Bacillus cereus and its close relatives take up soluble silicate from the environment and accumulate it as insoluble silica in and around the spore coat layer. However, the mechanism underlying silicate uptake has not been clarified. Recently, it has been reported that siderophores, natural iron-chelating compounds secreted by microorganisms, can form a complex with silicon. We hypothesized that siderophores might be involved in silicate uptake in B. cereus. The disruption of one of the two siderophore biosynthesis operons resulted in significant decrease in silicate uptake. However, medium exchange during cultivation did not affect silicate uptake, suggesting that siderophore-mediated transport is not a major route of silicate uptake.
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