Comprehensive analysis of intestinal colonization factors derived from gut microbes
| Project/Area Number |
16H04901
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied microbiology
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| Research Institution | Keio University |
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Principal Investigator |
Fukuda Shinji 慶應義塾大学, 政策・メディア研究科(藤沢), 特任教授 (80435677)
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| Co-Investigator(Kenkyū-buntansha) |
宮内 栄治 国立研究開発法人理化学研究所, 生命医科学研究センター, 基礎科学特別研究員 (60634706)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Keywords | 腸内細菌 / 代謝物質 / メタゲノム / メタボローム / メタボロゲノミクス / 相互作用 / 微生物社会 / 定着 / 腸内エコシステム / 腸内環境 / 腸内生態系 / 共生 / 統合オミクス |
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| Outline of Final Research Achievements |
The gut microbiota form a highly complex ecological community together with host intestinal cells. The so-called gut ecosystem has a profound influence on human physiology, immunology, and nutrition. It has been reported that imbalance in the structure of gut ecosystem could be a risk factor in human disorders including not merely gut-associated diseases but also systemic disorders. However, the molecular mechanisms of the formation of complex intestinal microbial community remain obscure. To this end, we firstly established a highly integrated metagenomic and metabolomic approaches, metabologenomics, and found that the interaction between host-derived IgA and number of colonized bacteria are important to form initial state of gut ecosystem, indicating that host-microbial crosstalk is one of the key systems to form complex microbial community in gut.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の意義は、腸内細菌が有する腸内環境定着因子を網羅的に解析し、腸内微生物共生社会形成機構を理解することで、腸内細菌叢のバランスの乱れが素因になる疾患の先制医療を目指した基盤技術の礎となると共に、予防医学や健康増進の見地に立ったサプリメントや機能性食品開発にも応用でき、それらの摂取によるセルフメディケーションにもつながると考えられる。
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Neonatal acquisition of Clostridia species protects against colonization by bacterial pathogens2017
Author(s)
Kim, YG., Sakamoto, K., Seo, SU., Pickard, JM., Gillilland, M.G. 3rd, Pudlo, NA., Hoostal, M., Li, X., Feehley, T., Stefka, AT., Schmidt, TM., Martens, EC., Fukuda, S., Inohara, N., Nagler, CR., Nunez, G.
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Journal Title
Science
Volume: 356
Issue: 6335
Pages: 315-319
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Evaluation of the impact of gut microbiota on uremic solute accumulation by a CE-TOFMS-based metabolomics approach2017
Author(s)
†Mishima, E., †Fukuda, S. (†equally contributed), Mukawa, C., Yuri, A., Kanemitsu, Y., Matsumoto, Y., Akiyama, Y., Fukuda, NN., Tsukamoto, H., Asaji, K., Shima, H., Kikuchi, K., Suzuki, T., Tomioka, Y., Soga, T., Ito, S., Abe, T.
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Journal Title
Kidney International
Volume: 92
Issue: 3
Pages: 634-645
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Functional characterization of inflammatory bowel disease-associated gut dysbiosis in gnotobiotic mice.2016
Author(s)
Nagao-Kitamoto, H., Shreiner, A.B., Gillilland, M.G. 3rd, Kitamoto, S., Ishii, C., Hirayama, A., Kuffa, P., El-Zaatari, M., Grasberger, H., Seekatz, A.M., Higgins, P.D., Young, V.B., Fukuda, S., Kao, J.Y., Kamada, N.
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Journal Title
Cell Mol. Gastroenterol. Hepatol.
Volume: 2
Issue: 4
Pages: 468-481
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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