Research Project
Grant-in-Aid for Scientific Research (B)
The gut microbiota form a highly complex ecological community together with host intestinal cells. The so-called gut ecosystem has a profound influence on human physiology, immunology, and nutrition. It has been reported that imbalance in the structure of gut ecosystem could be a risk factor in human disorders including not merely gut-associated diseases but also systemic disorders. However, the molecular mechanisms of the formation of complex intestinal microbial community remain obscure. To this end, we firstly established a highly integrated metagenomic and metabolomic approaches, metabologenomics, and found that the interaction between host-derived IgA and number of colonized bacteria are important to form initial state of gut ecosystem, indicating that host-microbial crosstalk is one of the key systems to form complex microbial community in gut.
本研究の意義は、腸内細菌が有する腸内環境定着因子を網羅的に解析し、腸内微生物共生社会形成機構を理解することで、腸内細菌叢のバランスの乱れが素因になる疾患の先制医療を目指した基盤技術の礎となると共に、予防医学や健康増進の見地に立ったサプリメントや機能性食品開発にも応用でき、それらの摂取によるセルフメディケーションにもつながると考えられる。
All 2018 2017 2016 Other
All Int'l Joint Research (2 results) Journal Article (6 results) (of which Int'l Joint Research: 2 results, Peer Reviewed: 5 results, Open Access: 4 results) Presentation (19 results) (of which Int'l Joint Research: 3 results, Invited: 19 results) Patent(Industrial Property Rights) (2 results)
Am J Physiol Renal Physiol
Volume: 315 Issue: 4 Pages: 824-833
10.1152/ajprenal.00314.2017
Science
Volume: 356 Issue: 6335 Pages: 315-319
10.1126/science.aag2029
Kidney International
Volume: 92 Issue: 3 Pages: 634-645
10.1016/j.kint.2017.02.011
Journal of Diabetes Investigation
Volume: 印刷中 Issue: 1 Pages: 5-12
10.1111/jdi.12673
Cell Mol. Gastroenterol. Hepatol.
Volume: 2 Issue: 4 Pages: 468-481
10.1016/j.jcmgh.2016.02.003
医学のあゆみ
Volume: 259 Pages: 1152-1160
