| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2018: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Outline of Final Research Achievements |
The plant growth regulator, prohexadione (PHX) is widely used in agronomic and horticultural crops to reduce unwanted longitudinal shoot growth without lowering plant productivity by inhibiting gibberellin (GA) biosynthesis enzyme.
We elucidated the co-crystal structure with the substrates GA and PHX using the GA biosynthetic enzyme, GA3-oxidase and the metabolic enzyme, GA2-oxidase, and estimated the amino acids that determine the difference in reactivity of both enzymes towards them. This will provide clues for elucidation of a series of mechanisms from GA biosynthesis to metabolic pathways, and it can be expected that it will lead to the development of novel plant growth regulator specific to both enzymes in the future.
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