| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2018: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
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| Outline of Final Research Achievements |
We identified the chemical structure of active selenium that was formed on the active site of thioredoxin as an intermediate in the process prior to the supply of selenium substrate to selenophosphate synthetase, which is required for selenoprotein biosynthesis. We also found a novel selenite reductase that has a selenocysteine residue and five c-type heme in a dissimilatory metal-reducing bacterium Geobacter sulfurreducens. The enzymatic properties of the selenoprotein was investigated. In addition, we showed that a gene encoding the novel selenite reductase is involved in the formation of elemental selenium on the surface of the bacterial cells.
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