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Visualization of food hydration structure and analysis of molecular mobility to elucidate the hydration state implied by water activity

Research Project

Project/Area Number 16H04928
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Food science
Research InstitutionJapan Atomic Energy Agency

Principal Investigator

Nakagawa Hiroshi  国立研究開発法人日本原子力研究開発機構, 原子力科学研究部門 原子力科学研究所 物質科学研究センター, 研究副主幹 (20379598)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2019: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2018: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Keywords水分活性 / 食品物理学 / ガラス転移 / 中性子散乱 / 水和 / デンプン / FT-IR
Outline of Final Research Achievements

By analyzing the molecular mobility of water molecule and visualizing the hydration structure using quasi-elastic neutron scattering, we investigated the physicochemical state of water in food and the interaction between food and water, and elucidated a part of the hydration state implied by water activity. Specifically, although water activity has been described in qualitative terms such as free water and bound water, it was shown that each state can be distinguished as a difference in the network structure of hydration water via hydrogen bonding. Each state was also quantitatively explained by the diffusion coefficient of water and the hydrogen bonding lifetime. Furthermore, we found that the change in hydration state was closely related to the presence or absence of a glass transition in the food molecules. On the other hand, the relationship with the food microstructure was also found to be important for a unified understanding of the water activity of foods.

Academic Significance and Societal Importance of the Research Achievements

水分活性は食品の保存性や品質を評価する実用的な指標であり、その有効性は広く認められており、食品加工などの現場で既に利活用されている。しかしながら、水分活性がなぜそのように食品の状態をうまく指標化できているのかなどについての学術的な観点からの研究は不十分な点が多い。本研究で解明した水分活性が意味する食品の水和状態を参照することによって、これまでと違った観点から水分活性の利用ができたり、食品の品質についてこれまで以上情報が引き出せたりできるようになる可能性を秘めている。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (36 results)

All 2020 2019 2018 2017 2016 Other

All Int'l Joint Research (1 results) Journal Article (12 results) (of which Peer Reviewed: 12 results,  Open Access: 3 results) Presentation (23 results) (of which Int'l Joint Research: 6 results,  Invited: 9 results)

  • [Int'l Joint Research] Jeulich Centre for Neutron Science(Germany)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Rigidity of protein structure revealed by incoherent neutron scattering2020

    • Author(s)
      Nakagawa Hiroshi、Kataoka Mikio
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - General Subjects

      Volume: 1864 Issue: 4 Pages: 129536-129536

    • DOI

      10.1016/j.bbagen.2020.129536

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sequence-dependent hydration water dynamics of dodecameric DNA2020

    • Author(s)
      H. Nakagawa, Y. Yonetani, K. Nakajima, Seiko Ohira-Kawamura, T Kikuchi, Y. Inamura, M. Kataoka and H. Kono
    • Journal Title

      the Proceedings of the 3rd J-PARC Symposium (J-PARC2019)

      Volume: -

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Position dependency of the scattered intensity in the time-of-flight backscattering spectrometer DNA2020

    • Author(s)
      Masato Matsuura, Takeshi Yamada, Taiki Tominaga, Makoto Kobayashi, Hiroshi Nakagawa, and Yukinobu Kawakita
    • Journal Title

      the Proceedings of the 3rd J-PARC Symposium (J-PARC2019)

      Volume: -

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quartz Cell for a Backscattering Spectrometer2020

    • Author(s)
      Taiki. Tominaga, Yukinobu. Kawakita, Hiroshi. Nakagawa, Takeshi. Yamada, and Kaoru. Shibata
    • Journal Title

      the Proceedings of the 3rd J-PARC Symposium (J-PARC2019)

      Volume: -

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Understanding water-mediated DNA damage production by molecular dynamics calculation of solvent accessibility2020

    • Author(s)
      Yoshiteru Yonetani and Hiroshi Nakagawa
    • Journal Title

      Chem. Phys. Lett

      Volume: 749 Pages: 137441-137441

    • DOI

      10.1016/j.cplett.2020.137441

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 中性子溶液散乱-現在・過去・未来2020

    • Author(s)
      杉山正明、井上倫太郎、中川洋、齊尾智英
    • Journal Title

      波紋

      Volume: 30 Pages: 16-25

    • NAID

      130008047185

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Universality and Structural Implications of the Boson Peak in Proteins2019

    • Author(s)
      Nakagawa Hiroshi、Joti Yasumasa、Kitao Akio、Yamamuro Osamu、Kataoka Mikio
    • Journal Title

      Biophysical Journal

      Volume: 117 Issue: 2 Pages: 229-238

    • DOI

      10.1016/j.bpj.2019.06.007

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular Basis of Water Activity in Glycerol?Water Mixtures2019

    • Author(s)
      Nakagawa Hiroshi、Oyama Taiji
    • Journal Title

      Frontiers in Chemistry

      Volume: 7 Pages: 731-731

    • DOI

      10.3389/fchem.2019.00731

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] How can we derive hydration water dynamics with incoherent neutron scattering and molecular dynamics simulation?2019

    • Author(s)
      Nakagawa H, Kataoka M
    • Journal Title

      Biophysics and Physicobiology

      Volume: 16 Issue: 0 Pages: 213-219

    • DOI

      10.2142/biophysico.16.0_213

    • NAID

      130007752723

    • ISSN
      2189-4779
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 食品の水分活性~中性子散乱による食品のミクロ構造解析と干し芋サイエンス~2018

    • Author(s)
      中川洋
    • Journal Title

      明日の食品産業

      Volume: 7・8 Pages: 23-30

    • NAID

      40021627675

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inelastic and quasi-elastic neutron scattering spectrometers in J-PARC2017

    • Author(s)
      H. Seto, S. Itoh, T. Yokoo , H. Endo, K. Nakajima , K. Shibata , R. Kajimoto, S. Ohira-Kawamura, M. Nakamura, Y. Kawakita, H. Nakagawa, T. Yamada
    • Journal Title

      Biochimica et Biophysica Acta

      Volume: 1861 Issue: 1 Pages: 3651-3660

    • DOI

      10.1016/j.bbagen.2016.04.025

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 中性子で展開される生命科学研究とその周辺のサイエンス2017

    • Author(s)
      中川洋、片岡幹雄
    • Journal Title

      日本加速器学会誌「加速器」

      Volume: 13 Pages: 214-219

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Presentation] 中性子準弾性散乱で解析する食品中の水の物理化学2020

    • Author(s)
      中川洋
    • Organizer
      PF研究会「量子ビームを活用した食品科学」
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 中性子準弾性・非弾性散乱による生体物質の構造物性ダイナミクス研究2020

    • Author(s)
      中川洋
    • Organizer
      2019年度MLFシンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] 非干渉性中性子準弾性散乱による生体物質の相転移と分子運動性の解析2019

    • Author(s)
      中川洋
    • Organizer
      第2回LLPS研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Water activity and glass transition of food protein studied by inelastic neutron scattering and molecular dynamics simulation2019

    • Author(s)
      H. Nakagawa
    • Organizer
      8th International Symposium on “Delivery of Functionality in Complex Food Systems
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 干し芋の水和状態・ミクロ構造と保存性・食感の関係2019

    • Author(s)
      中川洋、渡辺万里
    • Organizer
      つくばソフトマター研究会2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] タンパク質構造の硬さ・柔らかさと水和水ダイナミクス2019

    • Author(s)
      中川洋
    • Organizer
      ATI水和ナノ構造研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 中性子準弾性散乱による蛋白質の拡散運動と構造揺らぎの解析2019

    • Author(s)
      中川洋
    • Organizer
      蛋白質研究所セミナー
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 蛋白質ダイナミクスに対する水和・圧力・温度効果2019

    • Author(s)
      中川洋
    • Organizer
      生物の環境適応と分子科学
    • Related Report
      2019 Annual Research Report
  • [Presentation] QENS of protein solutions measured by the TOF near Backscattering Spectrometer DNA2019

    • Author(s)
      H. Nakagawa, T. Saio, T. Oda, M. Sato, R. Inoue, M. Sugiyama, T. Tominaga and Y. Kawakita
    • Organizer
      第3回J-PARCシンポジウム
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 中性子非弾性散乱・準弾性散乱と分子シミュレーションによる蛋白質ダイナミクスの解析2019

    • Author(s)
      中川洋
    • Organizer
      CBI学会2019年大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Protein dynamics and hydration by NIS2018

    • Author(s)
      Hiroshi Nakagawa
    • Organizer
      Dynamics of biomolecules and hydration water and neutron scattering
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 中性子分光法による生体物質ダイナミクス研究2018

    • Author(s)
      中川洋
    • Organizer
      QST高崎研オープンセミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] でんぷんの構造物性研究と干し芋サイエンス2018

    • Author(s)
      中川洋
    • Organizer
      「生物の環境適応と分子科学」研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Protein dynamics studied by quasi-elastic neutron scattering and molecular dynamics simulation2018

    • Author(s)
      Hiroshi Nakagawa
    • Organizer
      The 8th Taiwan-Japan Joint Meeting on Neutron and X-ray Scattering
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Correlative dynamical analysis of bio-molecules - quasi-elastic neutron scattering and computational analysis2017

    • Author(s)
      Hiroshi Nakagawa
    • Organizer
      Neutron Biology for Next Generation - staring at future -
    • Place of Presentation
      いばらき量子ビーム研究センター(茨城県東海村)
    • Year and Date
      2017-03-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 中性子散乱による生体分子の構造ダイナミクス研究2017

    • Author(s)
      中川洋、 片岡幹雄
    • Organizer
      日本物理学会 第72回年次大会
    • Place of Presentation
      大阪大学 豊中キャンパス(大阪府豊中市)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] 中性子散乱と計算機シミュレーションによる蛋白質の水和構造と分子運動性の解析2017

    • Author(s)
      中川洋
    • Organizer
      日本食品科学工学会第64回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Protein dynamics in viscosity solvent by neutron backscattering spectrometer2017

    • Author(s)
      Hiroshi Nakagawa
    • Organizer
      Frontier of Protein Dynamics Research
    • Related Report
      2017 Annual Research Report
  • [Presentation] Analysis of protein domain dynamics by integrating of neutron scattering and computer science2017

    • Author(s)
      Hiroshi Nakagawa
    • Organizer
      第55回日本生物物理学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 食品タンパク質の水分活性と水和のミクロ構造2017

    • Author(s)
      中川洋
    • Organizer
      関東東海北陸農業試験研究推進会議
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 中性子非弾性散乱による食品タンパク質の水和とガラス転移の解析2016

    • Author(s)
      中川洋
    • Organizer
      日本食品科学工学会第63回年会
    • Place of Presentation
      名城大学(愛知県名古屋市)
    • Year and Date
      2016-08-25
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 蛋白質の水和と水素結合ダイナミクス2016

    • Author(s)
      中川洋
    • Organizer
      第61回低温生物工学会大会
    • Place of Presentation
      東京電機大学 鳩山キャンパス(埼玉県鳩山町)
    • Year and Date
      2016-06-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] Glass transition and hydration of food protein studied by inelastic neutron scattering2016

    • Author(s)
      Hiroshi Nakagawa
    • Organizer
      Neutrons and Food 2016
    • Place of Presentation
      Lund, Sweden
    • Year and Date
      2016-05-31
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2021-02-19  

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