Mode of action and role of neurohormone in the regulation of reproductive functions and its application for artificial seed production in major bivalves
| Project/Area Number |
16H04978
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Aquatic life science
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| Research Institution | Tohoku University |
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Principal Investigator |
Osada Makoto 東北大学, 農学研究科, 教授 (30177208)
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| Co-Investigator(Kenkyū-buntansha) |
長澤 一衛 東北大学, 農学研究科, 助教 (50794236)
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2019: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2018: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
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| Keywords | 二枚貝 / 性分化 / 性成熟 / 産卵 / 神経内分泌 / GnRH / ステロイドホルモン / 性特異的遺伝子 / 二枚貝類 / 生殖 / 配偶子形成 / 水産学 / 生理学 |
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| Outline of Final Research Achievements |
Peptide sequences of gonadotropin releasing hormones (GnRHs), which are conserved among bivalves, was characterized in comparison with vertebrates. Induction of sex differentiation based on the observed difference of sex specific gene expression among sexes and germ cell development with two types of scallop GnRHs were demonstrated. And the occurrence of steroidogenic pathway-related genes, which is suggested mediating the abovementioned GnRH function, was proposed and sex specific profile of these genes between sexes during reproductive cycle was suggested.
Primary structure of oocyte maturation arresting factor (OMAF), which is a neural factor to interfere serotonin-induced spawning was revealed. And neutralizing full OMAF antibody resulted in blockage of OMAF-inhibited serotonin function and activation of spawning of male and sperm motility.
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| Academic Significance and Societal Importance of the Research Achievements |
近年、害的生物による食害や感染による斃死に加え、環境激変による資源量や養殖生産量の激減によって、環境と共生する漁業として世界に認められている、二枚貝養殖の持続的な生産が危ぶまれている。それを解決するためには、二枚貝の人工種苗生産技術の開発が急務である。
その基盤となる二枚貝における性分化・性成熟・産卵に関する生殖内分泌調節機構の知見を深化させ、人工種苗生産技術として応用する意義は、食料としての水産物増産のみならず、生殖内分泌機構に関わる生物の普遍的なメカニズムとその進化の解明においても非常に大きな意義がある。
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Report
(5 results)
Research Products
(51 results)
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[Journal Article] Glycan Binding Profiling of Jacalin-Related Lectins from the Pteria Penguin Pearl Shell2019
Author(s)
Tomohisa Ogawa, Rie Sato, Takako Naganuma, Kayeu Liu, Agness Ethel Lakudzala, Koji Muramoto, Makoto Osada, Kyosuke Yoshimi, Keiko Hiemori, Jun Hirabayashi, Hiroaki Tateno
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Journal Title
Int. J. Mol. Sci.
Volume: 20
Issue: 18
Pages: 4629-4629
DOI
Related Report
Peer Reviewed / Open Access
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