• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Sexual dimorphisms of the teleost brain: mechanisms of establishment and physiological significances

Research Project

Project/Area Number 16H04979
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Aquatic life science
Research InstitutionThe University of Tokyo

Principal Investigator

OKUBO Kataaki  東京大学, 大学院農学生命科学研究科(農学部), 准教授 (10370131)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2018: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Keywords水産学 / 生理学 / 脳・神経
Outline of Final Research Achievements

Teleost fish exhibit sexual dimorphisms in a range of traits that influence their productivity and economic value, including aggression, mating behavior, growth, sexual maturation, and stress response. Many of these sexual dimorphisms in traits presumably stem from those within their brains; however, it is still unclear what sexual dimorphisms exist within their brains, how these dimorphisms are established, and what traits these dimorphisms are relevant to. In this study, we focused on three sexual dimorphisms we have recently found in the medaka brain, and investigated the mechanisms of establishment and physiological significance of these dimorphisms.

Academic Significance and Societal Importance of the Research Achievements

本研究の成果によって、魚類の脳に存在する性的二型がどのような形質と結び付いているかの一端が明らかとなった。それにより、魚類における水産上の重要形質を生み出す生理機構が見えてきた。脊椎動物全体を見渡してみても、脳内の性的二型がどのような形質と結び付いているかを明らかにした研究は驚くほど少ない。本研究の成果は、魚類だけでなく、哺乳類を含めた脊椎動物全般での研究に大きなインパクトを与え得るものになり、学術的にも高い価値をもつと期待される。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (18 results)

All 2019 2018 2017 2016

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (14 results) (of which Int'l Joint Research: 3 results,  Invited: 5 results) Book (1 results)

  • [Journal Article] Sexually Dimorphic Neuropeptide B Neurons in Medaka Exhibit Activated Cellular Phenotypes Dependent on Estrogen2019

    • Author(s)
      Yukiko Kikuchi, Towako Hiraki-Kajiyama, Mikoto Nakajo, Chie Umatani, Shinji Kanda, Yoshitaka Oka, Keisuke Matsumoto, Hitoshi Ozawa, Kataaki Okubo
    • Journal Title

      Endocrinology

      Volume: 160 Issue: 4 Pages: 827-839

    • DOI

      10.1210/en.2019-00030

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A conceptual framework for understanding sexual differentiation of the teleost brain2019

    • Author(s)
      Okubo K, Miyazoe D, Nishiike Y
    • Journal Title

      General and Comparative Endocrinology

      Volume: in press Pages: 113129-113129

    • DOI

      10.1016/j.ygcen.2019.02.020

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of isotocin is male-specifically upregulated by gonadal androgen in the medaka brain2017

    • Author(s)
      Yamashita J, Kawabata Y, Okubo K
    • Journal Title

      J Neuroendocrinol

      Volume: 29 Issue: 12

    • DOI

      10.1111/jne.12545

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] メダカのメス特異的Npbニューロンの遺伝子発現プロファイルと機能の解析2018

    • Author(s)
      菊池結貴子・大久保範聡
    • Organizer
      第43回日本比較内分泌学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] メダカの脳と行動の性分化における性ステロイドの役割2018

    • Author(s)
      宮副大地・西池雄志・大久保範聡
    • Organizer
      第43回日本比較内分泌学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] メダカにおける攻撃行動に寄与する神経核の探索2018

    • Author(s)
      西池雄志・宮副大地・大久保範聡
    • Organizer
      第43回日本比較内分泌学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] メダカの視索前野に存在するメス特異的な性ステロイド応答性ニューロンの活性化に関わる遺伝子の探索2018

    • Author(s)
      立澤雅也・大久保範聡
    • Organizer
      第43回日本比較内分泌学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 魚類の性の不思議な世界2018

    • Author(s)
      大久保範聡
    • Organizer
      第11回日本性差医学・医療学会学術集会(公開シンポジウム「性差生物学の最近の進歩:進化の過程での性差」)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] エストロゲン受容体Esr2bノックアウトメダカの性行動と生殖腺における表現型解析2018

    • Author(s)
      宮副大地・大久保範聡
    • Organizer
      平成30年度日本水産学会春季大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] メダカの脳においてオスで高発現する神経ペプチド:オスでの高発現を生み出す二つのメカニズム2017

    • Author(s)
      山下純平・大久保範聡
    • Organizer
      平成29年度日本水産学会春季大会
    • Place of Presentation
      東京海洋大学品川キャンパス(東京都港区)
    • Year and Date
      2017-03-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] Molecular basis of sexual differentiation and plasticity of the teleost brain2017

    • Author(s)
      Kataaki Okubo
    • Organizer
      18th International Congress of Comparative Endocrinology (Grace Pickford Medal Lecture)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 真骨魚類の脳の性分化・性的可逆性に関する研究2017

    • Author(s)
      大久保範聡
    • Organizer
      第42回日本比較内分泌学会(日本比較内分泌学会奨励賞受賞者講演)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] メダカにおけるメス特異的なペプチド産生ニューロンの性ステロイド応答性と性的可逆性2017

    • Author(s)
      菊池結貴子・大久保範聡
    • Organizer
      第42回日本比較内分泌学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] エストロゲン受容体ノックアウトメダカを用いた魚類の行動の性差形成メカニズムの解析2017

    • Author(s)
      宮副大地・大久保範聡
    • Organizer
      第42回日本比較内分泌学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] メダカにおける脳型アロマターゼの生理的役割2016

    • Author(s)
      槇しずく・大久保範聡
    • Organizer
      第41回日本比較内分泌学会大会
    • Place of Presentation
      北里大学相模原キャンパス(神奈川県相模原市)
    • Year and Date
      2016-12-09
    • Related Report
      2016 Annual Research Report
  • [Presentation] Sexual differentiation and plasticity of the teleost brain2016

    • Author(s)
      Kataaki Okubo
    • Organizer
      The 22nd International Congress of Zoology
    • Place of Presentation
      沖縄科学技術大学院大学メインキャンパス(沖縄県国頭郡)
    • Year and Date
      2016-11-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Stress-related hormones in the medaka brain: identification of a new player and sex differences2016

    • Author(s)
      Kataaki Okubo
    • Organizer
      The 8th International Symposium on Fish Endocrinology
    • Place of Presentation
      Gothenburg (Sweden)
    • Year and Date
      2016-06-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Book] 魚の性(遺伝子から解き明かす性の不思議な世界、田中実編)2019

    • Author(s)
      大久保範聡・田中実・宮副大地
    • Total Pages
      544
    • Publisher
      一色出版
    • ISBN
      9784909383068
    • Related Report
      2018 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi