Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2019: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2018: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
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Outline of Final Research Achievements |
Marine sponges have been recognized as critical marine biochemical resources because some sponge-derived natural products are used as research reagents and chemotherapeutic agents. However, the lack of a sufficient supply of bioactive compounds for clinical development has been a problem. In this study, we focus on the sponge life cycle to identify biosynthetic gene clusters of bioactive natural products and their producers. As a result, we found the biosynthetic gene cluster of mycalolides, inhibitors of actin depolymerization, and its producing bacteria. We also revealed that the Mycale sponge inherits symbiotic bacteria producing mycalolides from parents to offspring via microbial transmission.
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