| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2019: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2018: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Outline of Final Research Achievements |
Blood IgY is incorporated into egg yolks of laying birds. The maternal IgY is essential for enhancing immunity of the new-born chicks. Uptake of blood IgY into egg yolks relies on the receptor present in the ovarian follicle, but there is no report to identify the receptor. In the present study, we tried to find out candidate receptor by comparing gene expression levels in oocytes of IgY-deficient or normal chickens. Two receptor candidate genes, LRP2L and FcRY, were selected from the genes in which the gene expression level was increased in IgY-deficient chickens compared to the control chicken. Synthesized recombinant FcRY bound to IgY, whereas recombinant LRP2L did not bind to IgY. The present study showed that FcRY expressed in ovarian follicles is involved in IgY transport into egg yolks in avian maternal immunity.
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