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The relationship between the feed management of dry period and liver function in dairy cows

Research Project

Project/Area Number 16H05021
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Animal production science
Research InstitutionHiroshima University

Principal Investigator

Sugino Toshihisa  広島大学, 統合生命科学研究科(生), 准教授 (90363035)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2019: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2018: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Keywords乳牛 / 周産期 / 乾乳期栄養水準 / 肝臓 / 脂質代謝 / 乾乳期 / 栄養水準 / 肝臓脂質代謝 / 畜産学 / 家畜飼養学 / 家畜栄養生理学 / 乳牛栄養学 / 乳牛周産期 / 乾乳期エネルギー水準 / 代謝ホルモン / エピジェネティクス / マウス周産期 / メチル化 / 脱メチル化 / 候補遺伝子
Outline of Final Research Achievements

This study aimed to evaluate the milk production and liver functions of multiparous high producing dairy cows fed two diets of differing energy levels (110 or 90% of ME requirements) in a one-phase dry period of 6 weeks. The prepartum dry matter intake was greater in the high than in the low ME group but the low ME group surpassed the high ME one in the DMI from the 1st to 3rd week postpartum. Milk yield did not differ between the high and the low ME diets from the 1st to the 8th week postpartum. The feed efficiency ratio tended to be lower in the low ME group from the 1st to 3rd week postpartum with no change thereafter. In liver function, PigK gene expression was increased after parturition in liver of low ME group. And Acaa1, Acaa2 and Sod1 gene expression before parturition were higher in low ME compared with high ME group. In conclusion, prepartum limited energy feeding in a one-phase dry period for 6 weeks could improve the postpartum DMI and energy balance.

Academic Significance and Societal Importance of the Research Achievements

最近,乳牛の育種改良に伴う高泌乳化によって,周産期を中心に代謝障害などの事故が多発している。その原因として乾乳期の栄養状態が挙げられている。乾乳期の栄養状態が分娩後の栄養代謝や乳生産に及ぼす影響は明らかにされつつあるが,その作用機序解明には至っておらず,本研究は学術的な意義を有する。乳生産に関して肝臓脂質代謝の重要時期は,泌乳初期であるが,最近では泌乳中期から後期にかけて過肥になる個体が酪農現場で多い。また,乾乳期の高栄養管理は泌乳中後期の乳量を減少させることから,長期的に脂質代謝への影響を明らかにする必要があり,本研究は,乾乳期の栄養水準の見直しに直結する課題である。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (9 results)

All 2020 2019 2018 Other

All Int'l Joint Research (1 results) Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (7 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Int'l Joint Research] University of Alberta(カナダ)

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Changes in rumen fermentation, bacterial community, and predicted functional pathway in Holstein cows with and without subacute ruminal acidosis during the periparturient period2020

    • Author(s)
      Tsuchiya Yoshiyuki、Chiba Ena、Sugino Toshihisa、Kawashima Kenji、Hasunuma Toshiya、Kushibiki Shiro、Kim Yo-Han、Sato Shigeru
    • Journal Title

      Journal of Dairy Science

      Volume: 103 Issue: 5 Pages: 4702-4716

    • DOI

      10.3168/jds.2019-17546

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Presentation] Effect of energy restriction during a one-phase dry period on the productive, metabolic and endocrine status of dairy cows.2019

    • Author(s)
      M. Elsabagh, T. Hasunuma, K. Kawashima, S. Sato, S. Kushibiki, T. Obitsu, T. Sugino.
    • Organizer
      17th International Conference on Production Diseases in Farm Animals
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 亜急性第一胃アシドーシス牛の分娩前後における第一胃液pH,VFAおよび細菌叢構成2019

    • Author(s)
      千葉恵樹,Yohan Kim,杉野利久,川嶋賢二,蓮沼俊哉,櫛引史郎,佐藤繁.
    • Organizer
      第162回日本獣医学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 亜急性第一胃アシドーシス牛の分娩前後における肝組織中の抗酸化関連遺伝子発現2019

    • Author(s)
      小材怜子,杉野利久,川嶋賢二,蓮沼俊哉,櫛引史郎,一條俊浩,佐藤繁.
    • Organizer
      第162回日本獣医学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 乳牛の分娩後における負のエネルギーバランスと血中MDA,GPxおよびPAO値の変化2019

    • Author(s)
      小材怜子,杉野利久,川嶋賢二,沖村朋子,櫛引史郎,一條俊浩,佐藤繁
    • Organizer
      日本畜産学会第126回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 亜急性第一胃アシドーシス牛の分娩前後における肝組織中遺伝子発現の変化2019

    • Author(s)
      千葉恵樹,Yohan Kim,杉野利久,川嶋賢二,沖村朋子,櫛引史郎,木崎景一郎,佐藤繁.
    • Organizer
      日本畜産学会第126回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 移行期の飼養管理2019

    • Author(s)
      杉野利久
    • Organizer
      日本家畜臨床学会共催公開シンポジウム“畜産研究の成果を獣医臨床フィールドへ”
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] プロモーター領域にCpG配列を有する脂質代謝関連遺伝子のマウス周産期における発現変化2018

    • Author(s)
      眞鍋 秀・河合 智子・島田 昌之・矢中 則之・小櫃 剛人・杉野 利久
    • Organizer
      日本畜産学会第124回大会
    • Related Report
      2017 Annual Research Report

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Published: 2016-04-21   Modified: 2021-02-19  

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