| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2019: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
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| Outline of Final Research Achievements |
Equine herpesvirus-1 (EHV-1) causes respiratory diseases, abortion and myeloencephalopathy in horses. Little is known about the mechanisms underlying latent EHV-1 infection, due to the lack of small animal models and in vitro infection models. In this study, we developed EHV-1-susceptible cell culture and murine systems by transduction of gene encoding EHV-1 entry receptor, and investigated their suitability as models of EHV-1 latent infection. A rat neuronal cell model showing differentiation dependent resistance to EHV-1 infection may be useful to unveiling the molecular mechanisms of EHV-1 neuropathogenicity and latency.
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