| Project/Area Number |
16H05026
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Veterinary medical science
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| Research Institution | Obihiro University of Agriculture and Veterinary Medicine |
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Principal Investigator |
Fukumoto Shinya 帯広畜産大学, 原虫病研究センター, 准教授 (50376422)
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| Co-Investigator(Kenkyū-buntansha) |
菅沼 啓輔 帯広畜産大学, 畜産学部, 助教 (60772184)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2018: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Keywords | ベクター / マラリア原虫 / マラリア / ハマダラカ / 感染症 |
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| Outline of Final Research Achievements |
In this study, we succeeded in identifying genes involved in bidirectional host transitions of rodent malaria parasite between mammalian host and vector insects. It was clarified that this was due to a decrease in reproductive maternal productivity, salivary gland sporozoite formation and infectivity. It has been revealed that the deficiency of this gene has high utility in the development of a live vaccine for malaria parasite. Two other host transition-related genes could be identified on a phenotype basis. Furthermore, we succeeded in developing a novel method for producing multiple mutants of rodent malaria parasites. It is expected that further development of these research results will lead to the control of vector-borne infectious diseases including malaria.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、マラリア原虫の昆虫と哺乳動物の移り変わりを両方向的に制御する遺伝子の同定に成功した。1遺伝子が双方向性の宿主移動を高いレベルで制御していることはマラリアの制御につながる学術的に重要な知見である。また、齧歯類マラリア原虫の実用的な多重変異体作製法の開発がなされたことを極めて学術的意義が大きい。さらに、遺伝子改変によるマラリア原虫感染防御生ワクチンの可能性を示すことができ、この結果は極めて社会的意義が高いものと考えられる。
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