| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
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| Outline of Final Research Achievements |
In this study, we analyzed the adhesion and binding between Staphylococcus aureus and host cells, the receptor and its molecular signal transduction mechanism at the molecular and cellular levels, using mutant toxins and strains lacking the superantigen activity. In addition, we elucidated the mechanism of persistent infectivity of S. aureus, and the protective effect of the mutant toxin immunization at the organism level. Furthermore, the protective antigen for next-generation vaccine against staphylococcal infection have be searched, suggesting that it could be applied to a new preventive method against S. aureus infection.
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