| Budget Amount *help |
¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
Fiscal Year 2019: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2018: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2017: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
The purpose of this study is to search biomarkers for bovine neurological diseases and clarify their clinical significance. Quantification of S100B, neuron specific enolase and phosphorylated neurofilament heavy chain in serum or cerebrospinal fluid of various neurological diseases showed that neurological diseases showed higher values than controls. However, low specificity and sensitivity were also found, thus it was thought that clinical application of these markers would be difficult. New biomarkers for disease-specific or nerve injury were surveyed. Antibody against Neospora caninum in cerebrospinal fluid was found to be a specific diagnostic marker for neosporosis of calves. As a result of comprehensive search by using proteome analysis, it was suggested that haptoglobin in cerebrospinal fluid could be a diagnostic marker for meningoencephalitis or similar diseases.
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